Cancerous, but not stromal, thrombospondin-2 contributes prognosis in pulmonary adenocarcinoma

Oncol Rep. 2009 Aug;22(2):279-83.

Abstract

Thrombospondin (TSP)-2 is known to be an endogenous negative regulator of vascularization in human cancer. However, it is unclear whether TSP-2 expression is related to neovascularization and prognosis in non-small cell lung cancer. In this study, we quantitatively examined the expression of TSP-2 mRNA by real-time reverse transcription-polymerase chain reaction (RT-PCR) in 102 pulmonary adenocarcinomas. All 102 carcinoma specimens expressed TSP-2 mRNA. The expression of TSP-2 mRNA in carcinoma was significantly higher than normal lung tissues (p<0.0001, Kruskal-Wallis test). Sizes of tumors were significantly correlated with TSP-2 gene expression (p=0.0179, Kruskal-Wallis test). The TSP-2 expression levels of the stage II/III pulmonary carcinomas were significantly increased as compared to those of stage I (p=0.0136, Kruskal-Wallis test). Thirty-five patients with high TSP-2 mRNA expression showed poor prognosis in survival (p=0.0139, log-rank test). We examined TSP-2 protein localizations in the pulmonary adenocarcinoma overexpressing TSP-2 mRNA. The TSP-2 localizations were categorized in two patterns: cancerous TSP-2 expression pattern (TSP-2 expression in the cancerous cells) and non-cancerous TSP-2 expression pattern (TSP-2 expression in the stromal lymphoid cells). Pulmonary adenocarcinoma patients with cancerous TSP-2 expression pattern showed good prognosis (p=0.0322; Fisher's probability exact test). Pulmonary adenocarcinoma patients with non-cancerous TSP-2 expression pattern showed poor prognosis (p=0.0220; Fisher's probability exact test). Non-cancerous TSP-2 expressions may reflect secondary reactions in the cancerous stroma. The stromal TSP-2 expression is not enough to suppress growth of pulmonary adenocarcinoma, while the cancerous TSP-2 expression directly inhibits growth of the carcinoma.

MeSH terms

  • Adenocarcinoma / blood supply
  • Adenocarcinoma / chemistry
  • Adenocarcinoma / mortality*
  • Aged
  • Female
  • Humans
  • Immunohistochemistry
  • Lung Neoplasms / blood supply
  • Lung Neoplasms / chemistry
  • Lung Neoplasms / mortality*
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Prognosis
  • RNA, Messenger / analysis
  • Stromal Cells / chemistry
  • Thrombospondins / analysis
  • Thrombospondins / genetics
  • Thrombospondins / physiology*

Substances

  • RNA, Messenger
  • Thrombospondins
  • thrombospondin 2