Simvastatin inhibits the proliferation and the contractility of human endometriotic stromal cells: a promising agent for the treatment of endometriosis

Kaei Nasu; Akitoshi Yuge; Akitoshi Tsuno; Hisashi Narahara

doi:10.1016/j.fertnstert.2009.06.055

Simvastatin inhibits the proliferation and the contractility of human endometriotic stromal cells: a promising agent for the treatment of endometriosis

Fertil Steril. 2009 Dec;92(6):2097-9. doi: 10.1016/j.fertnstert.2009.06.055. Epub 2009 Jul 30.

Authors

Kaei Nasu¹, Akitoshi Yuge, Akitoshi Tsuno, Hisashi Narahara

Affiliation

¹ Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan. nasu@med.oita-u.ac.jp

PMID: 19643402
DOI: 10.1016/j.fertnstert.2009.06.055

Abstract

Simvastatin significantly inhibited the proliferation of endometriotic stromal cells, attenuated the collagen gel contraction mediated by these cells, and suppressed endometriotic stromal cell attachment to collagen fibers. Simvastatin is considered to be a promising agent for the treatment of endometriosis-associated fibrosis, which is among the major pathologies caused by endometriosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Division / drug effects
Cells, Cultured
Collagen / metabolism
Endometriosis / drug therapy*
Endometriosis / pathology*
Female
Fibrosis
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology
In Vitro Techniques
Simvastatin / pharmacology*
Stromal Cells / drug effects*
Stromal Cells / metabolism
Stromal Cells / pathology*

Substances

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Collagen
Simvastatin