Abstract
The effects of melatonin, aluminum oxide, and polymethylsiloxane complex on the expression of LYVE-1 (lymphatic vessel endothelial hyaluronan receptor) in the liver were studied in db/db mice with experimental obesity and type 2 diabetes mellitus. The complex or placebo was administered daily by gavage from week 8 to week 16 of life. The animals receiving the complex exhibited enhanced, in comparison with the placebo group, immunohistochemical LYVE-1+ staining of endothelial cells in sinusoids. Enhanced expression of LYVE-1 was associated with less pronounced dilatation of interlobular arteries, veins, and lymphatic vessels. Thee findings suggest a protective effect of the complex towards structural changes in the liver of mice with obesity and type 2 diabetes.
Keywords: LYVE-1; liver; melatonin; sinusoidal cells; type 2 diabetes mellitus.
MeSH terms
- Aluminum Oxide / chemistry
- Animals
- Antioxidants / pharmacology*
- Blood Glucose / metabolism
- Diabetes Mellitus, Type 2 / drug therapy*
- Diabetes Mellitus, Type 2 / genetics
- Diabetes Mellitus, Type 2 / metabolism
- Diabetes Mellitus, Type 2 / pathology
- Disease Models, Animal
- Endothelial Cells / drug effects
- Endothelial Cells / metabolism
- Endothelial Cells / pathology
- Female
- Gene Expression / drug effects
- Glycoproteins / agonists*
- Glycoproteins / genetics
- Glycoproteins / metabolism
- Hepatic Artery / drug effects
- Hepatic Artery / metabolism
- Hepatic Artery / pathology
- Homozygote
- Hyperglycemia / drug therapy*
- Hyperglycemia / genetics
- Hyperglycemia / metabolism
- Hyperglycemia / pathology
- Liver / drug effects
- Liver / metabolism
- Liver / pathology
- Lymphatic Vessels / drug effects
- Lymphatic Vessels / metabolism
- Lymphatic Vessels / pathology
- Melatonin / pharmacology*
- Membrane Transport Proteins
- Mice
- Mice, Transgenic
- Obesity / drug therapy*
- Obesity / genetics
- Obesity / metabolism
- Obesity / pathology
- Receptors, Leptin / deficiency
- Receptors, Leptin / genetics
- Silicones / chemistry
Substances
- Antioxidants
- Blood Glucose
- Glycoproteins
- Membrane Transport Proteins
- Receptors, Leptin
- Silicones
- Xlkd1 protein, mouse
- leptin receptor, mouse
- polymethylsiloxane
- Melatonin
- Aluminum Oxide