MiR-628-5p decreases the tumorigenicity of epithelial ovarian cancer cells by targeting at FGFR2

Biochem Biophys Res Commun. 2018 Jan 8;495(2):2085-2091. doi: 10.1016/j.bbrc.2017.12.049. Epub 2017 Dec 9.

Abstract

Micro RNAs (miRNAs) are small non-coding RNAs which are 19-24 nucleotides in length. MiRNAs play a vital role in the whole process of tumour development, but how they influence the tumourigenecity of epithelial ovarian cancer (EOC)cells is rarely researched. In our study, it was verified that miR-628-5p decreased the stem like cell percentage of EOC cells by inducing their apoptosis. The animal experiments showed that miR-628-5p decreased the tumourigenecity of EOC cells. Besides, we found miR-628-5p targeted at and down-regulated the expression of fibroblast growth factor receptor 2 (FGFR2). FGFR2 expressed higher in ovarian cancer tissues and was correlated with worse prognosis. Our findings indicated that miR-628-5pplays an important role in ovarian cancer stem cell driven tumorigenesis.

Keywords: Cancer stem cell; Epithelial ovarian cancer; FGFR2; miR-628-5p.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis
  • Carcinogenesis / metabolism*
  • Carcinoma, Ovarian Epithelial
  • Cell Line, Tumor
  • Humans
  • MicroRNAs / metabolism*
  • Neoplasms, Glandular and Epithelial / metabolism*
  • Neoplasms, Glandular and Epithelial / pathology*
  • Neoplastic Stem Cells / metabolism*
  • Neoplastic Stem Cells / pathology*
  • Ovarian Neoplasms / metabolism*
  • Ovarian Neoplasms / pathology*
  • Receptor, Fibroblast Growth Factor, Type 2 / metabolism*

Substances

  • MIRN628 microRNA, human
  • MicroRNAs
  • FGFR2 protein, human
  • Receptor, Fibroblast Growth Factor, Type 2