1,25-dihydroxyvitamin D3 receptors in human leukocytes

Science. 1983 Sep 16;221(4616):1181-3. doi: 10.1126/science.6310748.

Abstract

A 1,25-dihydroxyvitamin D3 receptor macromolecule was detected in peripheral mononuclear leukocytes from normal humans. This macromolecule was found to be present in monocytes but absent from normal resting peripheral B and T lymphocytes. However, it was present in established lines of malignant B, T, and non-B, non-T human lymphocytes, as well as in T and B lymphocytes obtained from normal humans and activated in vitro.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • B-Lymphocytes / analysis
  • Cell Line
  • Humans
  • Leukemia / analysis
  • Leukocytes / analysis*
  • Lymphocyte Activation
  • Monocytes / analysis
  • Receptors, Calcitriol
  • Receptors, Steroid / analysis*
  • T-Lymphocytes / analysis

Substances

  • Receptors, Calcitriol
  • Receptors, Steroid