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Imaging Techniques in Pharmacological Precision Medicine

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Precision Medicine

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 280))

Abstract

Biomedical imaging is a powerful tool for medical diagnostics and personalized medicines. Examples of commonly used imaging modalities include Positron Emission Tomography (PET), Ultrasound (US), Single Photon Emission Computed Tomography (SPECT), and hybrid imaging. By combining these modalities, scientists can gain a comprehensive view and better understand physiology and pathology at the preclinical, clinical, and multiscale levels. This can aid in the accuracy of medical diagnoses and treatment decisions. Moreover, biomedical imaging allows for evaluating the metabolic, functional, and structural details of living tissues. This can be particularly useful for the early diagnosis of diseases such as cancer and for the application of personalized medicines. In the case of hybrid imaging, two or more modalities are combined to produce a high-resolution image with enhanced sensitivity and specificity. This can significantly improve the accuracy of diagnosis and offer more detailed treatment plans. In this book chapter, we showcase how continued advancements in biomedical imaging technology can potentially revolutionize medical diagnostics and personalized medicine.

We dedicate this work to Dr. James Ratnakar.

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Acknowledgments

We gratefully acknowledge the Swiss Werner Siemens Foundation and the Faculty of Medicine at the University of Tuebingen (Nachwuchsgruppen-Programm). The work was also supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy – EXC 2180-390900677 and by the Alexander von Humboldt Foundation through the Sofja Kovalevskaja award. We thank the colleagues Oliver Hihn, Gina Dunkel, Martina Giampetraglia, Dr. Marcel Krueger, and Prof. Dr. Bettina Weigelin at the Werner Siemens Imaging Center, University of Tübingen for kindly providing the FLM, BLI, MPM imaging.

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Authors and Affiliations

  1. Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, University of Tübingen, Tübingen, Germany

    Lucas Freidel, Sixing Li, Anais Choffart, Laura Kuebler & André F. Martins

  2. Cluster of Excellence iFIT (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies,” University of Tübingen, Tübingen, Germany

    Lucas Freidel, Sixing Li, Anais Choffart, Laura Kuebler & André F. Martins

  3. German Cancer Consortium (DKTK), Partner Site Tübingen, German Cancer Research Center (DKFZ), Heidelberg, Germany

    Laura Kuebler & André F. Martins

Authors
  1. Lucas Freidel
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  2. Sixing Li
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  3. Anais Choffart
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  4. Laura Kuebler
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  5. André F. Martins
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Corresponding author

Correspondence to André F. Martins .

Editor information

Editors and Affiliations

  1. Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Kiel, Germany

    Ingolf Cascorbi

  2. Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany

    Matthias Schwab

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© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

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Freidel, L., Li, S., Choffart, A., Kuebler, L., Martins, A.F. (2023). Imaging Techniques in Pharmacological Precision Medicine. In: Cascorbi, I., Schwab, M. (eds) Precision Medicine. Handbook of Experimental Pharmacology, vol 280. Springer, Cham. https://doi.org/10.1007/164_2023_641

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