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Grundlagen der Prävention

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Uroonkologie

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Zusammenfassung

Die »Reparaturmedizin« stößt in den letzten Jahren zunehmend an ihre Grenzen. Einerseits wirken sich medizinische Fortschritte in der Behandlung fortgeschrittener Tumoren kaum mehr messbar auf die Lebenserwartung der Gesamtbevölkerung aus. Zum anderen sind mit neuen Therapiekonzepten in der Regel hohe Kosten verbunden. Durch das Vermeiden von Erkrankungen könnte die Prävention sowohl die krankheitsbedingte als auch die therapiebezogene Morbidität und Mortalität senken. Theoretisch sind Einsparungen bei den Therapiekosten denkbar. Seit Jahren wird daher von Medizin und Politik die Bedeutung der Prävention für die moderne Medizin betont.

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Literatur

  • Albertsen K, Gronbaek M (2002) Does amount or type of alcohol influence the risk of prostate cancer? Prostate 52 (4): 297–304

    Article  PubMed  Google Scholar 

  • Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group (1994) The effect of vitamine E and beta carotene on the incidence of lung cancers and and other cancers in male smokers. N Engl J Med 300: 1029–35

    Article  Google Scholar 

  • Andriole G, Bostwick D, Brawley O, Gomella L, Marberger M, Tindall D, Breed S, Somerville M, Rittmaster R; REDUCE Study Group (2004) Chemoprevention of prostate cancer in men at high risk: rationale and design of the reduction by dutasteride of prostate cancer events (REDUCE) trial. J Urol 172: 1314–7

    Article  CAS  PubMed  Google Scholar 

  • Beauchamp GK, Keast RS, Morel D, Lin J, Pika J, Han Q, Lee CH, Smith AB, Breslin PA (2005) Phytochemistry: ibuprofen-like activity in extra-virgin olive oil. Nature 437: 45–6

    Article  CAS  PubMed  Google Scholar 

  • Becker N (2001) Epidemiologic aspects of cancer prevention in Germany. J Cancer Res Clin Oncol Jan 127 (1): 9–1

    Article  CAS  Google Scholar 

  • Bonovas S, Filioussi K, Sitaras NM (2008) Statin use and the risk of prostate cancer: A metaanalysis of 6 randomized clinical trials and 13 observational studies. Int J Cancer 123(4):899–904

    Article  CAS  PubMed  Google Scholar 

  • Bradbury BD, Wilk JB, Kaye JA (2005) Obesity and the risk of prostate cancer (United States). Cancer Causes Control Aug; 16 (6): 637–41

    Article  Google Scholar 

  • Brinkman M, Reulen RC, Kellen E, Buntinx F, Zeegers MP (2006) Are men with low selenium levels at increased risk of prostate cancer? Eur J Cancer 42(15): 2463–71

    Article  CAS  PubMed  Google Scholar 

  • Cao W, Cai L, Rao JY, Pantuck A, Lu ML, Dalbagni G, Reuter V, Scher H, Cordon-Cardo C, Figlin RA, Belldegrun A, Zhang ZF (2005) Tobacco smoking, GSTP1 polymorphism, and bladder carcinoma. Cancer Dec 1; 104 (11): 2400–8

    CAS  Google Scholar 

  • Clark LC, Combs GF Jr, Turnball BW et al. (1996) Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin: a randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA 276: 1957–63

    Article  CAS  PubMed  Google Scholar 

  • Cohen JH, Kristal AR, Stanford JL. Fruit and vegetable intakes and prostate cancer risk. J Natl Cancer Inst 2000; 92: 61–8

    Article  CAS  PubMed  Google Scholar 

  • Costello AJ (2001) A randomized, controlled chemoprevention trial of selenium in familial prostate cancer: Rationale, recruitment, and design issues. Urology 57 (4 Suppl 1): 182–4

    Article  CAS  PubMed  Google Scholar 

  • Cross AJ, Peters U, Kirsh VA, Andriole GL, Reding D, Hayes RB, Sinha R (2005) A prospective study of meat and meat mutagens and prostate cancer risk. Cancer Res 65: 11779–84

    Article  CAS  PubMed  Google Scholar 

  • Dennis LK, Snetselaar LG, Smith BJ, Stewart RE, Robbins ME (2004) Problems with the assessment of dietary fat in prostate cancer studies. Am J Epidemiol Sep 1; 160 (5): 436–44

    Google Scholar 

  • Djousse L, Schatzkin A, Chibnik LB, D’Agostino RB, Kreger BE, Ellison RC (2004) Alcohol consumption and the risk of bladder cancer in the Framingham Heart Study. J Natl Cancer Inst Sep 15; 96 (18): 1397–400

    Google Scholar 

  • Eichholzer M, Bernasconi F, Jordan P, Stahelin HB (2005) Body mass index and the risk of male cancer mortality of various sites: 17-year follow-up of the Basel cohort study. Swiss Med Wkly Jan 8; 135 (1–2): 27–33

    Google Scholar 

  • Engeland A, Tretli S, Bjorge T (2003) Height, body mass index, and prostate cancer: a follow-up, of 950000 Norwegian men. Br J Cancer Oct 6; 89 (7): 1237–1242

    Article  CAS  Google Scholar 

  • Farwell WR, Scranton RE, Lawler EV, Lew RA, Brophy MT, Fiore LD, Gaziano JM (2008) The association between statins and cancer incidence in a veterans population. J Natl Cancer Inst 100(2): 134–9

    Article  CAS  PubMed  Google Scholar 

  • Flaherty KT, Fuchs CS, Colditz GA, Stampfer MJ, Speizer FE, Willett WC, Curhan GC (2005) A prospective study of body mass index, hypertension, and smoking and the risk of renal cell carcinoma (United States). Cancer Causes Control Nov 16 (9): 1099–106

    Article  Google Scholar 

  • Fraser ML, Lee AH, Binns CW (2005) Lycopene and prostate cancer: emerging evidence. Expert Rev Anticancer Ther 5 (5): 847–54

    Article  CAS  PubMed  Google Scholar 

  • Freedland SJ, Platz EA, Presti JC Jr, Aronson WJ, Amling CL, Kane CJ, Terris MK (2006) Obesity, serum prostate specific antigen and prostate size: implications for prostate cancer detection. J Urol 175 (2): 500–504

    Article  PubMed  Google Scholar 

  • Friedenreich CM, Thune I (2001) A review of physical activity and prostate cancer risk. Cancer Causes Control 12 (5): 461–75

    Article  CAS  PubMed  Google Scholar 

  • Gaziano JM, Glynn RJ, Christen WG, Kurth T, Belanger C, Macfadyen J, Bubes V, Manson JE, Sesso HD, Buring JE (2008) Vitamins E and C in the Prevention of Prostate and Total Cancer in Men: The Physicians’ Health Study II Randomized Controlled Trial. JAMA [Epub ahead of print]

    Google Scholar 

  • Giovannucci E, Liu Y, Stampfer MJ, Willett WC (2006) A prospective study of calcium intake and incident and fatal prostate cancer. Cancer Epidemiol Biomarkers Prev 15(2): 203–10

    Article  CAS  PubMed  Google Scholar 

  • Giovannucci E, Rimm EB, Liu Y, Leitzmann M, Wu K, Stampfer MJ, Willett WC (2003) Body mass index and risk of prostate cancer in U.S. health professionals. J Natl Cancer Inst 95 (16): 1240–4

    PubMed  Google Scholar 

  • Gonzalez CA (2006) The European Prospective Investigation into Cancer and Nutrition (EPIC). Public Health Nutr 9 (1A): 124–6

    Article  PubMed  Google Scholar 

  • Hsieh LJ, Carter HB, Landis PK, Tucker KL, Metter EJ, Newschaffer CJ, Platz EA. (2003) Association of energy intake with prostate cancer in a long-term aging study: Baltimore Longitudinal Study of Aging (United States). Urology 61: 297–301

    Article  PubMed  Google Scholar 

  • Kellen E, Zeegers M, Paulussen A, Van Dongen M, Buntinx F (2006) Fruit consumption reduces the effect of smoking on bladder cancer risk. The Belgian case control study on bladder cancer Int J Cancer 118 (10): 2572–8

    Article  CAS  PubMed  Google Scholar 

  • Kirsh VA, Hayes RB, Mayne ST, Chatterjee N, Subar AF, Dixon LB, Albanes D, Andriole GL, Urban DA, Peters U; PLCO Trial (2006) Supplemental and dietary vitamin E, beta-carotene, and vitamin C intakes and prostate cancer risk. J Natl Cancer Inst 98: 245–54

    Article  CAS  PubMed  Google Scholar 

  • Kirsh VA, Mayne ST, Peters U, Chatterjee N, Leitzmann MF, Dixon LB, Urban DA, Crawford ED, Hayes RB (2006) A prospective study of lycopene and tomato product intake and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 15: 92–8

    Article  CAS  PubMed  Google Scholar 

  • Klein EA, Thompson IM (2004) Update on chemoprevention of prostate cancer. Curr Opin Urol 14: 143–9

    Article  PubMed  Google Scholar 

  • Klein EA. Selenium and vitamin E cancer prevention trial. Ann NY Acad Sci 1031: 234–241

    Google Scholar 

  • Klotz L, Saad F; PCPT-ATOPS Consensus Panel (2007) PCPT, MTOPS and the use of 5ARIs: a Canadian consensus regarding implications for clinical practice. Can Urol Assoc J 1(1): 17–21

    PubMed  Google Scholar 

  • Laaksonen DE, Laukkanen JA, Niskanen L, Nyyssonen K, Rissanen TH, Voutilainen S, Pukkala E, Hakkarainen A, Salonen JT (2004) Serum linoleic and total polyunsaturated fatty acids in relation to prostate and other cancers: a population-based cohort study. Int J Cancer 111 (3): 444–450

    Article  CAS  PubMed  Google Scholar 

  • MacLean CH, Newberry SJ, Mojica WA, Khanna P, Issa AM, Suttorp MJ, Lim YW, Traina SB, Hilton L, Garland R, Morton SC (2006) Effects of omega-3 fatty acids on cancer risk: a systematic review. JAMA 295 (4): 403–15

    Article  CAS  PubMed  Google Scholar 

  • Mahmud S, Franco E, Aprikian A (2004) Prostate cancer and use of nonsteroidal anti-inflammatory drugs: systematic review and meta-analysis. Br J Cancer 90: 93–9

    Article  CAS  PubMed  Google Scholar 

  • Malik A, Afaq F, Sarfaraz S, Adhami VM, Syed DN, Mukhtar H (2005) Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer. Proc Natl Acad Sci USA 102: 14813–8

    Article  CAS  PubMed  Google Scholar 

  • Malila N, Virtanen MJ, Virtamo J, Albanes D, Pukkala E (2006) Cancer incidence in a cohort of Finnish male smokers. Eur J Cancer Prev 15 (2): 103–7

    Article  PubMed  Google Scholar 

  • Marcus PM, Hayes RB, Vineis P, Garcia-Closas M, Caporaso NE, Autrup H, Branch RA, Brockmoller J, Ishizaki T, Karakaya AE, Ladero JM, Mommsen S, Okkels H, Romkes M, Roots I, Rothman N Cigarette smoking, N-acetyltransferase 2 acetylation status, and bladder cancer risk: a case-series meta-analysis of a gene-environment interaction. Cancer Epidemiol Biomarkers Prev 9 (5): 461–7

    Google Scholar 

  • Meyer F, Galan P, Douville P, Bairati I, Kegle P, Bertrais S, Estaquio C, Hercberg S (2005) Antioxidant vitamin and mineral supplementation and prostate cancer prevention in the SU.VI.MAX trial. Int J Cancer 116: 182–186

    Article  CAS  PubMed  Google Scholar 

  • Morris JD, Pramanik R, Zhang X, Carey AM, Ragavan N, Martin FL, Muir GH (2006) Selenium-or quercetin-induced retardation of DNA synthesis in primary prostate cells occurs in the presence of a concomitant reduction in androgen-receptor activity. Cancer Lett 239(1): 111–22

    Article  CAS  PubMed  Google Scholar 

  • Moyad MA (2002) Dietary fat reduction to reduce prostate cancer risk: controlled enthusiasm, learning a lesson from breast or other cancers, and the big picture. Urology 59 (4 Suppl 1): 51–62

    Article  PubMed  Google Scholar 

  • Moyad MA (2004) Why a statin and/or another proven heart healthy agent should be utilized in the next major cancer chemoprevention trial: part I. Urol Oncol 22: 466–71

    CAS  PubMed  Google Scholar 

  • Moyad MA (2004) Why a statin and/or another proven heart healthy agent should be utilized in the next major cancer chemoprevention trial: part II. Urol Oncol 22: 472–77

    CAS  PubMed  Google Scholar 

  • Navarro Silvera SA, Rohan TE (2007) Trace elements and cancer risk: a review of the epidemiologic evidence. Cancer Causes Control 18(1): 7–27

    Article  PubMed  Google Scholar 

  • Nicodemus KK, Sweeney C, Folsom AR (2004) Evaluation of dietary, medical and lifestyle risk factors for incident kidney cancer in postmenopausal women. Int J Cancer 108 (1): 115–121

    Article  CAS  PubMed  Google Scholar 

  • Oliveria SA, Lee IM (1997) Is exercise beneficial in the prevention of prostate cancer? Sports Med 23 (5): 271–8

    Article  CAS  PubMed  Google Scholar 

  • Packianathan S, Mehta RG, Mehta RR, Hall WH, Boerner PS Beckett LA, Vijayakumar S (2004) Designing a randomized phase I/II prostate cancer chemoprevention trial using 1alpha-hydroxy-24-ethyl-cholecalciferol, an analogue of vitamin D3. Cancer J 10: 357–367

    Article  CAS  PubMed  Google Scholar 

  • Psichon T, Lahmann PH, Boeing H, Tjonneland A, Halkjaer J, Overvad K, Klipstein-Grobusch K, Linseisen J, Becker N, Trichopoulou A, Benetou V, Trichopoulos D, Sieri S, Palli D, Tumino R, Vineis P, Panico S, Monninkhof E, Peeters PH, Bueno-de-Mesquita HB, Buchner FL, Ljungberg B, Hallmans G, Berglund G, Gonzalez CA, Dorronsoro M, Gurrea AB, Navarro C, Martinez C, Quiros JR, Roddam A, Allen N, Bingham S, Khaw KT, Kaaks R, Norat T, Slimani N, Riboli E (2006) Body size and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC). Int J Cancer 118 (3): 728–738

    Article  CAS  Google Scholar 

  • Porter MP Stanford JL (2005) Obesity and the risk of prostate cancer. Prostate 62 (4): 316–321

    Article  PubMed  Google Scholar 

  • Price D, Stein B, Goluboff E, Sieber P, Bostwick D, Barnette KG, Steiner MS (2005) Toremifene for the prevention of prostate cancer among 514 men with high-grade prostatic intraepithelial neoplasia (PIN): results of a double-blind, placebo-controlled phase IIB trial. J Urol 173: abstract 690

    Google Scholar 

  • Qin LQ, Xu JY, Wang PY, Kaneko T, Hoshi K, Sato A (2004) Milk consumption is a risk factor for prostate cancer: meta-analysis of case-control studies. Nutr Cancer 48 (1): 22–27

    Article  PubMed  Google Scholar 

  • Rashidkhani B, Akesson A, Lindblad P, Wolk A (2005) Major dietary patterns and risk of renal cell carcinoma in a prospective cohort of Swedish women. J Nutr 135 (7): 1757–1762

    CAS  PubMed  Google Scholar 

  • Rashidkhani B, Lindblad P, Wolk A (2005) Fruits, vegetables and risk of renal cell carcinoma: a prospective study of Swedish women. Int J Cancer Jan 20; 113 (3): 451–5

    Article  CAS  Google Scholar 

  • Roberts EG, Vona-Davis L, Riggs DR, Jackson BJ, Hohseni H, Kandzari SJ, McFadden DW (2004) COX-2 inhibition and cancer: experimental findings and clinical correlates. W V Med J 100: 96–10

    PubMed  Google Scholar 

  • Sarvis JA, Thompson IM (2008) Prostate cancer chemoprevention: update of the prostate cancer prevention trial findings and implications for clinical practice. Curr Oncol Rep 10(6): 529–32

    Article  CAS  PubMed  Google Scholar 

  • Scardino P (2003) The prevention of prostate cancer — the dilemma continues. N Engl J Med 349: 297–9

    Article  PubMed  Google Scholar 

  • Schmitz-Dräger BJ, Eichholzer M, Beiche B, Ebert T (2001) Nutrition and Prostate Cancer. Urol Int 67: 1–11

    Article  PubMed  Google Scholar 

  • Sommer F, Peters C, Klotz T, Michna H, Schoenenberger A, Engelmann U (2002) Sport und Bewegung in der Prävention urologischer Erkrankungen. Teil I: Uroonkologie und erektile Dysfunktion. Urologe B 42: 297–305

    Google Scholar 

  • Steinmaus CM, Nunez S, Smith AH (2000) Diet and bladder cancer: a meta-analysis of six dietary variables. Am J Epidemiol 151 (7): 693–702

    CAS  PubMed  Google Scholar 

  • Strom SS, Wang X, Pettaway CA, Logothetis CJ, Yamamura Y, Do KA, Babaian RJ, Troncoso P (2005) Obesity, weight gain, and risk of biochemical failure among prostate cancer patients following prostatectomy. Clin Cancer Res 11: 6889–94

    Article  CAS  PubMed  Google Scholar 

  • Tavani A, Bertuccio P, Bosetti C, Talamini R, Negri E, Franceschi S, Montella M, La Vecchia C (2005) Dietary intake of calcium, vitamin D, phosphorus and the risk of prostate cancer. Eur Urol 48: 27–33

    Article  CAS  PubMed  Google Scholar 

  • Taylor ML, Wells BJ, Smolak MJ (2008) Statins and cancer: a meta-analysis of case-control studies. Eur J Cancer Prev 17(3): 259–68

    Article  PubMed  Google Scholar 

  • Thomas LG (2005) Increased risk of cardiovascular events with coxibs and NSAIDs. Lancet; 365: 1538–9

    Article  CAS  PubMed  Google Scholar 

  • Thompson IM, Goodman PJ, Tangen CM, Lucia MS, Miller GJ, Ford LG, Lieber MM, Cespedes RD, Atkins JN, Lippman SM, Carlin SM, Ryan A, Szczepanek CM, Crowley JJ, Coltman CA Jr (2003) The influence of finasteride on the development of prostate cancer. N Engl J Med 349: 215–24

    Article  CAS  PubMed  Google Scholar 

  • Unger JM, LeBlanc M, Thompson IM, Coltman CA Jr (2004) The person-years saved model and other methodologies for assessing the population impact of cancer-prevention strategies. Urol Oncol 22: 362–8

    PubMed  Google Scholar 

  • van den Brandt PA, Zeegers MP, Bode P, Goldbohm RA (2003) Toenail selenium levels and the subsequent risk of prostate cancer: a prospective cohort study. Cancer Epidemiol Biomarkers Prev 12: 866–71

    PubMed  Google Scholar 

  • van Dijk BA, Schouten LJ, Kiemeney LA, Goldbohm RA, van den Brandt PA (2005) Vegetable and fruit consumption and risk of renal cell carcinoma: results from the Netherlands cohort study. Int J Cancer 117 (4): 648–54

    Article  PubMed  CAS  Google Scholar 

  • Wannamethee SG, Shaper AG, Walker M (2001) Physical activity and risk of cancer in middle-aged men. Br J Cancer 85 (9): 1311–6

    Article  CAS  PubMed  Google Scholar 

  • Zeegers MP, Dirx MJ, van den Brandt PA (2005) Physical activity and the risk of prostate cancer in the Netherlands cohort study, results after 9.3 years of follow-up. Cancer Epidemiol Biomarkers Prev 14 (6): 1490–5

    Article  PubMed  Google Scholar 

  • Zeegers MP, Goldbohm RA, Bode P, van den Brandt PA (2002) Prediagnostic toenail selenium and risk of bladder cancer. Cancer Epidemiol Biomarkers Prev 11 (11): 1292–7

    CAS  PubMed  Google Scholar 

  • Zeegers MP, Kellen E, Buntinx F, van den Brandt PA (2004) The association between smoking, beverage consumption, diet and bladder cancer: a systematic literature review. World J Urol 21 (6): 392–401

    Article  PubMed  Google Scholar 

  • Zeegers MP, Volovics A, Dorant E, Goldbohm RA, van den Brandt PA (2001) Alcohol consumption and bladder cancer risk: results from The Netherlands Cohort Study. Am J Epidemiol 153 (1): 38–41

    Article  CAS  PubMed  Google Scholar 

  • Zhang J, Kesteloot H (2005) Milk consumption in relation to incidence of prostate, breast, colon, and rectal cancers: is there an independent effect? Nutr Cancer 53 (1): 65–72

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Urologische Gemeinschaftspraxis, Euro Med. Clinic, Europa-Allee 1, 90763, Fürth

    Prof. Dr. med. B J Schmitz-Dräger

  2. Abt. für Urologie, Uroonkologie und Kinderurologie, St. Josef Hospital, Hospitalstraße 46, 53840, Troisdorf

    Priv. Doz. Dr. med. G Lümmen

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Arbeitskreis Prävention, Umwelt und komplementäre und alternative Medizin (AK KAM) von DGU und BDU

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  1. Universitätsklinikum Essen, Hufelandstraße 55, 45122, Essen

    Herbert Rübben (Direktor der Klinik und Poliklinik für Urologie) (Direktor der Klinik und Poliklinik für Urologie)

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Schmitz-Dräger, B.J., Lümmen, G., Arbeitskreis Prävention, Umwelt und komplementäre und alternative Medizin (AK KAM) von DGU und BDU. (2009). Grundlagen der Prävention. In: Rübben, H. (eds) Uroonkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01382-9_6

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