MIND diet slows cognitive decline with aging
Corresponding Author
Martha Clare Morris
Department of Internal Medicine at Rush University Medical Center, Chicago, IL, USA
Corresponding author. Tel.: +1-312-942-3223; Fax: +1-312-942-2861.
E-mail address: [email protected]
Search for more papers by this authorChristy C. Tangney
Department of Clinical Nutrition at Rush University Medical Center, Chicago, IL, USA
Search for more papers by this authorYamin Wang
Department of Internal Medicine at Rush University Medical Center, Chicago, IL, USA
Search for more papers by this authorFrank M. Sacks
Department of Nutrition, Harvard School of Public Health, Harvard University, Boston, MA, USA
Search for more papers by this authorLisa L. Barnes
Department of Behavioral Sciences at Rush University Medical Center, Chicago, IL, USA
Department of Neurological Sciences at Rush University Medical Center, Chicago, IL, USA
Rush Alzheimer's Disease Center at Rush University Medical Center, Chicago, IL, USA
Search for more papers by this authorDavid A. Bennett
Department of Neurological Sciences at Rush University Medical Center, Chicago, IL, USA
Rush Alzheimer's Disease Center at Rush University Medical Center, Chicago, IL, USA
Search for more papers by this authorNeelum T. Aggarwal
Department of Neurological Sciences at Rush University Medical Center, Chicago, IL, USA
Rush Alzheimer's Disease Center at Rush University Medical Center, Chicago, IL, USA
Search for more papers by this authorCorresponding Author
Martha Clare Morris
Department of Internal Medicine at Rush University Medical Center, Chicago, IL, USA
Corresponding author. Tel.: +1-312-942-3223; Fax: +1-312-942-2861.
E-mail address: [email protected]
Search for more papers by this authorChristy C. Tangney
Department of Clinical Nutrition at Rush University Medical Center, Chicago, IL, USA
Search for more papers by this authorYamin Wang
Department of Internal Medicine at Rush University Medical Center, Chicago, IL, USA
Search for more papers by this authorFrank M. Sacks
Department of Nutrition, Harvard School of Public Health, Harvard University, Boston, MA, USA
Search for more papers by this authorLisa L. Barnes
Department of Behavioral Sciences at Rush University Medical Center, Chicago, IL, USA
Department of Neurological Sciences at Rush University Medical Center, Chicago, IL, USA
Rush Alzheimer's Disease Center at Rush University Medical Center, Chicago, IL, USA
Search for more papers by this authorDavid A. Bennett
Department of Neurological Sciences at Rush University Medical Center, Chicago, IL, USA
Rush Alzheimer's Disease Center at Rush University Medical Center, Chicago, IL, USA
Search for more papers by this authorNeelum T. Aggarwal
Department of Neurological Sciences at Rush University Medical Center, Chicago, IL, USA
Rush Alzheimer's Disease Center at Rush University Medical Center, Chicago, IL, USA
Search for more papers by this authorThe authors have no relevant disclosures of potential conflicts of interest.
Abstract
Introduction
The Mediterranean and dash diets have been shown to slow cognitive decline; however, neither diet is specific to the nutrition literature on dementia prevention.
Methods
We devised the Mediterranean-Dietary Approach to Systolic Hypertension (DASH) diet intervention for neurodegenerative delay (MIND) diet score that specifically captures dietary components shown to be neuroprotective and related it to change in cognition over an average 4.7 years among 960 participants of the Memory and Aging Project.
Results
In adjusted mixed models, the MIND score was positively associated with slower decline in global cognitive score (β = 0.0092; P < .0001) and with each of five cognitive domains. The difference in decline rates for being in the top tertile of MIND diet scores versus the lowest was equivalent to being 7.5 years younger in age.
Discussion
The study findings suggest that the MIND diet substantially slows cognitive decline with age. Replication of these findings in a dietary intervention trial would be required to verify its relevance to brain health.
Supporting Information
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