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Endoplasmic Reticulum-Directed Ratiometric Fluorescent Probe for Quantitive Detection of Basal H2O2

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Key Laboratory of Cluster Science of the Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, School of Chemistry, Beijing Institute of Technology, Beijing 100081, People’s Republic of China
*Phone/fax: +86 010 88875298. E-mail: [email protected]
*Phone/fax: +86 010 88875298. E-mail: [email protected]
*Phone/fax: +86 010 88875298. E-mail: [email protected]
Cite this: Anal. Chem. 2017, 89, 23, 12945–12950
Publication Date (Web):November 13, 2017
https://doi.org/10.1021/acs.analchem.7b03809
Copyright © 2017 American Chemical Society
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    Abstract

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    The endoplasmic reticulum (ER) has a central role in the fine-tuning of environmental and internal stimuli. We herein report a ratiometric fluorescent probe, α-Naph, capable of determining basal H2O2 in the ER. The probe specifically responds to H2O2. The limit of detection of the probe is as low as 38 nM, making it a feasible sensor to image intracellular basal H2O2. In addition, utilizing its ratiometric property, we are able to measure the concentration of H2O2 in the ER quantitatively, eliminating the error caused by the probe concentration and environment. The intracellular concentration of H2O2 in the ER is calculated to be 0.692 μM under normal conditions and 1.26 μM under the stimulation of phorbol myristate acetate.

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    7. Wei Shu, Shunping Zang, Chong Wang, Mengxu Gao, Jing Jing, Xiaoling Zhang. An Endoplasmic Reticulum-Targeted Ratiometric Fluorescent Probe for the Sensing of Hydrogen Sulfide in Living Cells and Zebrafish. Analytical Chemistry 2020, 92 (14) , 9982-9988. https://doi.org/10.1021/acs.analchem.0c01623
    8. Jinliang Han, Xingjiang Liu, Haiqing Xiong, Jingpei Wang, Benhua Wang, Xiangzhi Song, Wei Wang. Investigation of the Relationship Between H2O2 and HClO in Living Cells by a Bifunctional, Dual-ratiometric Responsive Fluorescent Probe. Analytical Chemistry 2020, 92 (7) , 5134-5142. https://doi.org/10.1021/acs.analchem.9b05604
    9. Yazhou Liu, Jing Jing, Fei Jia, Sa Su, Yong Tian, Na Gao, Chunlei Yang, Rubo Zhang, Weizhi Wang, Xiaoling Zhang. Tumor Microenvironment-Responsive Theranostic Nanoplatform for in Situ Self-Boosting Combined Phototherapy through Intracellular Reassembly. ACS Applied Materials & Interfaces 2020, 12 (6) , 6966-6977. https://doi.org/10.1021/acsami.9b22097
    10. Jun Liu, Jingjing Liang, Chuanliu Wu, Yibing Zhao. A Doubly-Quenched Fluorescent Probe for Low-Background Detection of Mitochondrial H2O2. Analytical Chemistry 2019, 91 (10) , 6902-6909. https://doi.org/10.1021/acs.analchem.9b01294
    11. Cheng Zhang, Peng Wang, Xia Yin, Hong-Wen Liu, Yue Yang, Liang Cheng, Guosheng Song, Xiao-Bing Zhang. Two-Photon Supramolecular Nanoplatform for Ratiometric Bioimaging. Analytical Chemistry 2019, 91 (9) , 6371-6377. https://doi.org/10.1021/acs.analchem.9b01455
    12. Yen Leng Pak, Sang Jun Park, Gyeongok Song, Yubin Yim, Hyuk Kang, Hwan Myung Kim, Jean Bouffard, Juyoung Yoon. Endoplasmic Reticulum-Targeted Ratiometric N-Heterocyclic Carbene Borane Probe for Two-Photon Microscopic Imaging of Hypochlorous Acid. Analytical Chemistry 2018, 90 (21) , 12937-12943. https://doi.org/10.1021/acs.analchem.8b03565
    13. Xinya Jiang, Huijun Wang, Ruo Yuan, Yaqin Chai. Functional Three-Dimensional Porous Conductive Polymer Hydrogels for Sensitive Electrochemiluminescence in Situ Detection of H2O2 Released from Live Cells. Analytical Chemistry 2018, 90 (14) , 8462-8469. https://doi.org/10.1021/acs.analchem.8b01168
    14. Xuewei Li, Weimin Liu, Yanping Wang, Zhongjiao Feng, Jie Sha, Lin Shan, Haohui Ren, Pengfei Wang. Near-infrared fluorescent probe for the simultaneous dual-color monitoring of pH changes in two organelles. Dyes and Pigments 2024, 224 , 111997. https://doi.org/10.1016/j.dyepig.2024.111997
    15. Yingsong Zhou, Xuan Zhang, Julien S. Baker, Gareth W. Davison, Xiaojun Yan. Redox signaling and skeletal muscle adaptation during aerobic exercise. iScience 2024, 27 (5) , 109643. https://doi.org/10.1016/j.isci.2024.109643
    16. Yuanqing Hua, Xianghuan Si, Dongna Li, Zhen Li, Tianshu Xu. Hydrogen peroxide fluorescent probe–monitored butyric acid inhibition of the ferroptosis process. Luminescence 2024, 39 (3) https://doi.org/10.1002/bio.4715
    17. Feng Gao, Yanjing Zhao, Xiaowei Shi, Dan Qiao, Chao Pei, Xianghui Kong. Signalling regulation of reactive oxygen species in fish inflammation. Reviews in Aquaculture 2024, https://doi.org/10.1111/raq.12895
    18. Bingpeng Guo, Mengyu Li, Guiwen Hao, Liangchen Wei, Honghan Sa, Jianbin Chen, Wei Shu, Changxiang Shao. A ratiometric fluorescent probe for imaging the fluctuation of HOBr during endoplasmic reticulum stress. Journal of Materials Chemistry B 2024, 12 (4) , 1001-1006. https://doi.org/10.1039/D3TB02679E
    19. Yiping Liu, Juan Fu, Jiaxing Wan, Tongsheng Huang, Weifeng Zhu, Jianwen Tian, Meiying Liu, Xiaoyong Zhang, Yen Wei. One-step synthesis of a dual-functional AIE-active probe for ClO − detection and photodynamic therapy. Chemical Communications 2024, 60 (8) , 984-987. https://doi.org/10.1039/D3CC05927H
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    21. Andrea del Campo, Rodrigo Valenzuela, Luis Alberto Videla, Jessica Zúñiga-Hernandez. Cellular Functional, Protective or Damaging Responses Associated with Different Redox Imbalance Intensities: A Comprehensive Review. Current Medicinal Chemistry 2023, 30 (34) , 3927-3939. https://doi.org/10.2174/0929867330666221209093343
    22. Peipei Zong, Yunling Chen, Jianling Bi, Kejia Han, Jinlan Luo, Xiaohui Wang, Fangong Kong, Keyin Liu. Development of a novel chitosan-based two-photon fluorescent nanoprobe with enhanced stability for the specific detection of endogenous H2O2. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2023, 298 , 122797. https://doi.org/10.1016/j.saa.2023.122797
    23. Calford Wai‐Ting Chan, Angela Sin‐Yee Law, Vivian Wing‐Wah Yam. A Luminescence Assay in the Red for the Detection of Hydrogen Peroxide and Glucose Based on Metal Coordination Polyelectrolyte‐Induced Supramolecular Self‐Assembly of Alkynylplatinum(II) Complexes. Chemistry – A European Journal 2023, 29 (47) https://doi.org/10.1002/chem.202300203
    24. Zhaolun Liang, Zhiyong Jiang, Changli Zhang, Zhipeng Liu. A ratiometric fluorescent probe for selective imaging of methylglyoxal in living cells. Journal of Molecular Structure 2023, 1285 , 135484. https://doi.org/10.1016/j.molstruc.2023.135484
    25. Manoj Kumar Goshisht, Neetu Tripathi, Goutam Kumar Patra, Manohar Chaskar. Organelle-targeting ratiometric fluorescent probes: design principles, detection mechanisms, bio-applications, and challenges. Chemical Science 2023, 14 (22) , 5842-5871. https://doi.org/10.1039/D3SC01036H
    26. Jinzhu Gao, Rongchen Wang, Kai Yin, Tianli Zhu, Jie Sun, Chengjun Dong, Xuemei Dong, Mengting Zhao, Xianfeng Gu, Chunchang Zhao. Visualizing hydrogen peroxide and hydrogen sulfide fluctuations in living cells via dynamic-reversible fluorescent probes. Chemical Engineering Journal 2023, 466 , 143102. https://doi.org/10.1016/j.cej.2023.143102
    27. Junqing Zhang, Yongkang Zhang, Hao Zhang, Wenhao Zhai, Xiaoqian Shi, Changhua Li. A hypoxia-activatable theranostic agent with intrinsic endoplasmic reticulum affinity and type-I photosensitivity. Journal of Materials Chemistry B 2023, 11 (18) , 4102-4110. https://doi.org/10.1039/D3TB00328K
    28. Negar Alizadeh, Abdollah Salimi. Electrochemical monitoring of hydrogen peroxide by a signal-amplified microfluidic chip coupled with colloidal VO 2 nanostructures as a peroxidase enzyme mimic. Analytical Methods 2023, 15 (15) , 1896-1902. https://doi.org/10.1039/D3AY00203A
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    30. Yves S. Kafuti, Shuang Zeng, Xiaosheng Liu, Jingjing Han, Ming Qian, Qixian Chen, Jingyun Wang, Xiaojun Peng, Juyoung Yoon, Haidong Li. Observing hydrogen sulfide in the endoplasmic reticulum of cancer cells and zebrafish by using an activity-based fluorescent probe. Chemical Communications 2023, 59 (17) , 2493-2496. https://doi.org/10.1039/D2CC06645A
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    32. Liam D. Adair, Nian Kee Tan, Elizabeth J. New. Activity‐based Fluorescent Sensors and Their Applications in Biological Studies. 2022, 129-172. https://doi.org/10.1002/9781119749844.ch5
    33. Xia Zhang, Li Zhang, Xinyan Cheng, Shudi Liu, Shujing Fang, Liangwei Zhang, Xiaoyan Wang, Lingxin Chen. Fluorescence imaging to probe mercury induced oxidative stress in living systems. Sensors and Actuators B: Chemical 2022, 366 , 131982. https://doi.org/10.1016/j.snb.2022.131982
    34. Tao Ma, Kai Fu, Zhichun Li, Chuangchun Yuan, Wenbing Ma. A novel hydrogen peroxide fluorescent probe for bioimaging detection and enables multiple redox cycles. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2022, 276 , 121218. https://doi.org/10.1016/j.saa.2022.121218
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    36. Shuoshuo Wang, Jipeng Yao, Bei Wang, Xiang Liu. A ratiometric and two‐photon fluorescent probe for imaging hydrogen peroxide in living cells. Luminescence 2022, 37 (6) , 1037-1043. https://doi.org/10.1002/bio.4234
    37. Nadeem Ahmed, Wajeeha Zareen, Yong Ye. Recent development in fluorescent probes based on attacking of double bond and masking of functional group. Chinese Chemical Letters 2022, 33 (6) , 2765-2772. https://doi.org/10.1016/j.cclet.2021.12.092
    38. Clémentine Rouyère, Thomas Serrano, Stéphane Frémont, Arnaud Echard. Oxidation and reduction of actin: Origin, impact in vitro and functional consequences in vivo. European Journal of Cell Biology 2022, 101 (3) , 151249. https://doi.org/10.1016/j.ejcb.2022.151249
    39. Sergey Zavadskiy, Susanna Sologova, Nurbubu Moldogazieva. Oxidative distress in aging and age-related diseases: Spatiotemporal dysregulation of protein oxidation and degradation. Biochimie 2022, 195 , 114-134. https://doi.org/10.1016/j.biochi.2021.12.002
    40. A. Ledo, E. Fernandes, A. Salvador, J. Laranjinha, R.M. Barbosa. In vivo hydrogen peroxide diffusivity in brain tissue supports volume signaling activity. Redox Biology 2022, 50 , 102250. https://doi.org/10.1016/j.redox.2022.102250
    41. Fuyan Tang, Chuanchen Wu, Zhaodong Zhai, Kai Wang, Xueli Liu, Haibin Xiao, Shuping Zhuo, Ping Li, Bo Tang. Recent progress in small-molecule fluorescent probes for endoplasmic reticulum imaging in biological systems. The Analyst 2022, 147 (6) , 987-1005. https://doi.org/10.1039/D1AN02290C
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    43. Bo Chen, Chang‐Sheng Kuai, Jian‐Xing Xu, Xiao‐Feng Wu. Manganese(III)‐Promoted Double Carbonylation of Anilines Toward α‐Ketoamides Synthesis. Advanced Synthesis & Catalysis 2022, 364 (3) , 487-492. https://doi.org/10.1002/adsc.202101233
    44. Sheng Wang, Yu Zhang, Tian-Ran Wang, Yu-Jun Liu, Shi-Li Shen, Xiao-Qun Cao. A near-infrared fluorescent probe based on the hemicyanine skeleton for the detection of hydrogen peroxide in vivo. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2022, 266 , 120435. https://doi.org/10.1016/j.saa.2021.120435
    45. Yong Zhang, Min Yang, Yuesong Wang, Weiye Huang, Min Ji. Lighting up hydrogen peroxide in living cells by a novel quinoxalinamine based fluorescent probe. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2022, 267 , 120528. https://doi.org/10.1016/j.saa.2021.120528
    46. Xiwei Li, Na Gao, Caiyun Liu, Miaohui Yu, Xiaodi Rong, Yan Zhang, Meijun Su, Xin Wang, Hanchuang Zhu, Kun Wang, Yilin Liu, Wenlong Sheng, Baocun Zhu. A melatonin-based targetable fluorescent probe activated by hydrogen peroxide for tumor cells screening. Sensors and Actuators B: Chemical 2022, 353 , 131051. https://doi.org/10.1016/j.snb.2021.131051
    47. Jaidev Kaushik, Gunture, Kumud Malika Tripathi, Ravindra Singh, Sumit Kumar Sonkar. Thiourea-functionalized graphene aerogel for the aqueous phase sensing of toxic Pb(II) metal ions and H2O2. Chemosphere 2022, 287 , 132105. https://doi.org/10.1016/j.chemosphere.2021.132105
    48. Ying-Jie Tang, Shan He, Xiao-Feng Guo, Hong Wang. A redox reversible endoplasmic reticulum-targeted fluorescent probe for revealing the redox status of living cells. The Analyst 2021, 146 (24) , 7740-7747. https://doi.org/10.1039/D1AN01587G
    49. Anwesha Maiti, Saikat Kumar Manna, Dipanjan Banik, Ajit Kumar Mahapatra. Name reactions: strategies in the design of chemodosimeters for analyte detection. New Journal of Chemistry 2021, 45 (43) , 20046-20074. https://doi.org/10.1039/D1NJ04056A
    50. Yue Wang, Fang Zhou, Qingtao Meng, Songhe Zhang, Hongmin Jia, Cuiping Wang, Run Zhang, Zhiqiang Zhang. A Novel Fluorescence Probe for the Reversible Detection of Bisulfite and Hydrogen Peroxide Pair in Vitro and in Vivo. Chemistry – An Asian Journal 2021, 16 (21) , 3419-3426. https://doi.org/10.1002/asia.202100926
    51. Keying Zhang, Ziqiang Zhang, Shangshang Ma, Deshun Cheng, Mengdi Fan, Xinyu Zhou, Fajun Li, Na Zhang. Crumpled Graphene/Poly (azure I) Modified Electrode for Non-enzymatic Detection of Hydrogen Peroxide Secreted from Tumor Cells. Analytical Sciences 2021, 37 (10) , 1367-1372. https://doi.org/10.2116/analsci.21P003
    52. Hengzhi Zhao, Yazhou Liu, Jie Cui, Chunlei Yang, Na Gao, Jing Jing, Xiaoling Zhang. Enzyme-triggered DNA nanomimosa: A ratiometric nanoprobe for RNase H activity sensing in living cells. Talanta 2021, 233 , 122547. https://doi.org/10.1016/j.talanta.2021.122547
    53. Meng He, Miantai Ye, Zhengguo Wang, Pan Liu, Huiyue Li, Chunfeng Lu, Yanying Wang, Tao Liang, Haiyan Li, Chunya Li. A ratiometric near-infrared fluorescent probe with a large emission peak shift for sensing and imaging hypochlorous acid. Sensors and Actuators B: Chemical 2021, 343 , 130063. https://doi.org/10.1016/j.snb.2021.130063
    54. Rongrong Zhou, Qiyao Peng, Dan Wan, Chao Yu, Yuan Zhang, Yi Hou, Quan Luo, Xiong Li, Shuihan Zhang, Lin Xie, Pinghua Ou, Yongbo Peng. Construction of a lysosome-targetable ratiometric fluorescent probe for H 2 O 2 tracing and imaging in living cells and an inflamed model. RSC Advances 2021, 11 (39) , 24032-24037. https://doi.org/10.1039/D1RA04026J
    55. Sivakalai Mayakrishnan, Masilamani Tamizmani, Chandrasekar Balachandran, Shin Aoki, Narayanan Uma Maheswari. Rh( iii )-Catalysed synthesis of cinnolinium and fluoranthenium salts using C–H activation/annulation reactions: organelle specific mitochondrial staining applications. Organic & Biomolecular Chemistry 2021, 19 (24) , 5413-5425. https://doi.org/10.1039/D1OB00376C
    56. Fenghui Zhu, Xiuyun Wang, Xiaowen Yang, Chenfei Zhao, Yue Zhang, Siqi Qu, Shuo Wu, Wei Ji. Reasonable design of an MXene-based enzyme-free amperometric sensing interface for highly sensitive hydrogen peroxide detection. Analytical Methods 2021, 13 (22) , 2512-2518. https://doi.org/10.1039/D1AY00568E
    57. Won-Chun Oh, Chang Sung Lim, Yin Liu, Suresh Sagadevan, Won Kweon Jang, Md Rokon Ud Dowla Biswas. Quaternary nanorod-type BaInSbSe5 semiconductor combined graphene-based conducting polymer (PPy) nanocomposite and highly sensing performance of H2O2 & H2S gases. Journal of Materials Science: Materials in Electronics 2021, 32 (12) , 15944-15963. https://doi.org/10.1007/s10854-021-06145-5
    58. Helmut Sies. Oxidative eustress: On constant alert for redox homeostasis. Redox Biology 2021, 41 , 101867. https://doi.org/10.1016/j.redox.2021.101867
    59. Jie Cui, Shunping Zang, Hailiang Nie, Tiaojiao Shen, Sa Su, Jing Jing, Xiaoling Zhang. An ICT-based fluorescent probe for ratiometric monitoring the fluctuations of peroxynitrite in mitochondria. Sensors and Actuators B: Chemical 2021, 328 , 129069. https://doi.org/10.1016/j.snb.2020.129069
    60. Yingying Shi, Sijie Wang, Jialu Wu, Xizhi Jin, Jian You. Pharmaceutical strategies for endoplasmic reticulum-targeting and their prospects of application. Journal of Controlled Release 2021, 329 , 337-352. https://doi.org/10.1016/j.jconrel.2020.11.054
    61. Ning Feng, Jingjing Shen, Yu Chen, Chang Li, Yanling Hu, Lei Zhang, Shufen Chen, Quli Fan, Wei Huang, Lianhui Wang. Multifunctional shape-dependent plasmonic nanoprobe by enzymatic etching of single gold triangular nanoplate. Nano Research 2020, 13 (12) , 3364-3370. https://doi.org/10.1007/s12274-020-3023-2
    62. Qiujuan Ma, Chunyan Wang, Guojiang Mao, Meiju Tian, Jingguo Sun, Suxiang Feng. An endoplasmic reticulum-targeting and ratiometric fluorescent probe for hypochlorous acid in living cells based on a 1,8-naphthalimide derivative. New Journal of Chemistry 2020, 44 (42) , 18389-18398. https://doi.org/10.1039/D0NJ04045B
    63. Lifeng Cui, Chengyun Li, Biyun Chen, Hong Huang, Qineng Xia, Xi Li, Zhangfeng Shen, Zhigang Ge, Yangang Wang. Surface functionalized red fluorescent dual-metallic Au/Ag nanoclusters for endoplasmic reticulum imaging. Microchimica Acta 2020, 187 (11) https://doi.org/10.1007/s00604-020-04585-0
    64. Junpeng Xu, Yu-Liang Tsai, Shan-hui Hsu. Design Strategies of Conductive Hydrogel for Biomedical Applications. Molecules 2020, 25 (22) , 5296. https://doi.org/10.3390/molecules25225296
    65. Fanyong Yan, Yueyan Zang, Jingru Sun, Zhonghui Sun, Hao Zhang. Sensing mechanism of reactive oxygen species optical detection. TrAC Trends in Analytical Chemistry 2020, 131 , 116009. https://doi.org/10.1016/j.trac.2020.116009
    66. Jennifer M. Roscoe, Carolyn S. Sevier. Pathways for Sensing and Responding to Hydrogen Peroxide at the Endoplasmic Reticulum. Cells 2020, 9 (10) , 2314. https://doi.org/10.3390/cells9102314
    67. Xiaonan Gao, Congcong Zhao, Keyan Wei, Bo Hu, Yuqin Chen, Kehua Xu, Bo Tang. A differential study on oxidized/reduced ascorbic acid induced tumor cells’ apoptosis under hypoxia. The Analyst 2020, 145 (19) , 6363-6368. https://doi.org/10.1039/D0AN01011A
    68. Tingting Yang, Junyong Sun, Wu Yao, Feng Gao. A two-photon fluorescent probe for turn-on monitoring HOCl level in endoplasmic reticulum. Dyes and Pigments 2020, 180 , 108435. https://doi.org/10.1016/j.dyepig.2020.108435
    69. Gangbing Zhu, Dongyan Huang, Lirong Liu, Yinhui Yi, Yuntao Wu, Yongqiang Huang. One-Step Green Preparation of N-Doped Silicon Quantum Dots for the on-off Fluorescent Determination of Hydrogen Peroxide. Analytical Letters 2020, 53 (11) , 1834-1849. https://doi.org/10.1080/00032719.2020.1720222
    70. Helmut Sies, Dean P. Jones. Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nature Reviews Molecular Cell Biology 2020, 21 (7) , 363-383. https://doi.org/10.1038/s41580-020-0230-3
    71. Tianjiao Shen, Shunping Zang, Wei Shu, Longxue Nie, Jing Jing, Xiaoling Zhang. A ratiometric fluorescent probe for mitochondrial esterase specific detection in living cells. Dyes and Pigments 2020, 178 , 108345. https://doi.org/10.1016/j.dyepig.2020.108345
    72. Wen-Li Jiang, Wen-Xin Wang, Juan Liu, Yongfei Li, Chun-Yan Li. A novel hepatocyte-targeting ratiometric fluorescent probe for imaging hydrogen peroxide in zebrafish. Sensors and Actuators B: Chemical 2020, 313 , 128054. https://doi.org/10.1016/j.snb.2020.128054
    73. Yuangong Zhang, Libin Bai, Feng Liu, Ye Zhang, Yongqiang Cheng, Hailei Zhang, Xinwu Ba. A novel fluorescent glycopolymer for endogenous hydrogen peroxide imaging in living cells in a fully aqueous environment. Polymer Journal 2020, 52 (5) , 481-491. https://doi.org/10.1038/s41428-019-0290-4
    74. Tianchu Gu, Shanyan Mo, Yingqi Mu, Xin Huang, Liming Hu. Detection of endogenous hydrogen peroxide in living cells with para-nitrophenyl oxoacetyl rhodamine as turn-on mitochondria-targeted fluorescent probe. Sensors and Actuators B: Chemical 2020, 309 , 127731. https://doi.org/10.1016/j.snb.2020.127731
    75. Shunping Zang, Xiangxue Kong, Jie Cui, Sa Su, Wei Shu, Jing Jing, Xiaoling Zhang. Revealing the redox status in endoplasmic reticulum by a selenium fluorescence probe. Journal of Materials Chemistry B 2020, 8 (13) , 2660-2665. https://doi.org/10.1039/C9TB02919B
    76. Parvej Alam, Wei He, Nelson L. C. Leung, Chao Ma, Ryan T. K. Kwok, Jacky W. Y. Lam, Herman H. Y. Sung, Ian D. Williams, Kam Sing Wong, Ben Zhong Tang. Red AIE‐Active Fluorescent Probes with Tunable Organelle‐Specific Targeting. Advanced Functional Materials 2020, 30 (10) https://doi.org/10.1002/adfm.201909268
    77. . Real-time Monitoring of Intracellular Reactive Oxygen Species. 2020, 144-169. https://doi.org/10.1039/9781839160455-00144
    78. Digamber Rane, Erick J. Carlson, Yuwen Yin, Blake R. Peterson. Fluorescent detection of peroxynitrite during antibody-dependent cellular phagocytosis. 2020, 1-35. https://doi.org/10.1016/bs.mie.2020.04.001
    79. Daria Sicari, Agnès Delaunay‐Moisan, Laurent Combettes, Eric Chevet, Aeid Igbaria. A guide to assessing endoplasmic reticulum homeostasis and stress in mammalian systems. The FEBS Journal 2020, 287 (1) , 27-42. https://doi.org/10.1111/febs.15107
    80. Jun Jiao, Liqi Wen, Zihua Wang, Bingkai Han, Li Zhao, Qiang Chen. Highly Sensitive Sensor Based on Pt@MnO 2 /rGO Nanosheets as a Platform for Real-time Monitoring Cellular ROS and its Application in Diverse Cancers. Journal of The Electrochemical Society 2020, 167 (6) , 067524. https://doi.org/10.1149/1945-7111/ab8367
    81. Gozal Fazli, Sedigheh Esmaeilzadeh Bahabadi, Laleh Adlnasab, Hamid Ahmar. A glassy carbon electrode modified with a nanocomposite prepared from Pd/Al layered double hydroxide and carboxymethyl cellulose for voltammetric sensing of hydrogen peroxide. Microchimica Acta 2019, 186 (12) https://doi.org/10.1007/s00604-019-3967-7
    82. Xue Zhang, Yanan Chen, Caiyun Liu, Zihan Zhuang, Zilu Li, Pan Jia, Hanchuang Zhu, Yamin Yu, Baocun Zhu, Wenlong Sheng. A novel hexahydropyridazin-modified rhodamine fluorescent probe for tracing endogenous/exogenous peroxynitrite in live cells and zebrafish. Dyes and Pigments 2019, 170 , 107573. https://doi.org/10.1016/j.dyepig.2019.107573
    83. Yaru Lu, Baoli Dong, Wenhui Song, Xiuqi Kong, Abdul Hadi Mehmood, Weiying Lin. An endoplasmic reticulum-targeting fluorescent probe for the imaging of hypochlorous acid in living cells and zebrafishes. Journal of Photochemistry and Photobiology A: Chemistry 2019, 384 , 111980. https://doi.org/10.1016/j.jphotochem.2019.111980
    84. Da-Jun Zheng, Yu-Shun Yang, Hai-Liang Zhu. Recent progress in the development of small-molecule fluorescent probes for the detection of hydrogen peroxide. TrAC Trends in Analytical Chemistry 2019, 118 , 625-651. https://doi.org/10.1016/j.trac.2019.06.031
    85. Congcong Gao, Shunping Zang, Longxue Nie, Yong Tian, Rubo Zhang, Jing Jing, Xiaoling Zhang. A sensitive ratiometric fluorescent probe for quantitive detection and imaging of alkaline phosphatase in living cells. Analytica Chimica Acta 2019, 1066 , 131-135. https://doi.org/10.1016/j.aca.2019.03.043
    86. Wenhao Dong, Yipeng Ren, Zhixue Bai, Yi Yang, Qiang Chen. Fabrication of hexahedral Au-Pd/graphene nanocomposites biosensor and its application in cancer cell H2O2 detection. Bioelectrochemistry 2019, 128 , 274-282. https://doi.org/10.1016/j.bioelechem.2019.04.018
    87. Tingting Meng, Jing Han, Pengfei Zhang, Jing Hu, Junjie Fu, Jian Yin. Introduction of the α-ketoamide structure: en route to develop hydrogen peroxide responsive prodrugs. Chemical Science 2019, 10 (30) , 7156-7162. https://doi.org/10.1039/C9SC00910H
    88. Tianlin Wang, Yun Chai, Shuhan Chen, Guichun Yang, Cuifen Lu, Junqi Nie, Chao Ma, Zuxing Chen, Qi Sun, Yuexing Zhang, Jun Ren, Feiyi Wang, Wei-Hong Zhu. Near-infrared fluorescent probe for imaging nitroxyl in living cells and zebrafish model. Dyes and Pigments 2019, 166 , 260-265. https://doi.org/10.1016/j.dyepig.2019.03.013
    89. Peng Gao, Wei Pan, Na Li, Bo Tang. Fluorescent probes for organelle-targeted bioactive species imaging. Chemical Science 2019, 10 (24) , 6035-6071. https://doi.org/10.1039/C9SC01652J
    90. Yuanyuan Liu, Chunpeng Jiao, Wenjuan Lu, Pingping Zhang, Yanfeng Wang. Research progress in the development of organic small molecule fluorescent probes for detecting H 2 O 2. RSC Advances 2019, 9 (31) , 18027-18041. https://doi.org/10.1039/C9RA02467K
    91. Fangyun Xin, Yong Tian, Congcong Gao, Bingpeng Guo, Yulong Wu, Junfang Zhao, Jing Jing, Xiaoling Zhang. A two-photon fluorescent probe for basal formaldehyde imaging in zebrafish and visualization of mitochondrial damage induced by FA stress. The Analyst 2019, 144 (7) , 2297-2303. https://doi.org/10.1039/C8AN02108B
    92. Congcong Gao, Yong Tian, Rubo Zhang, Jing Jing, Xiaoling Zhang. Mitochondrial directed ratiometric fluorescent probe for quantitive detection of sulfur dioxide derivatives. New Journal of Chemistry 2019, 43 (13) , 5255-5259. https://doi.org/10.1039/C8NJ05951A
    93. Ji-Ting Hou, Hyeong Seok Kim, Chong Duan, Myung Sun Ji, Shan Wang, Lintao Zeng, Wen Xiu Ren, Jong Seung Kim. A ratiometric fluorescent probe for detecting hypochlorite in the endoplasmic reticulum. Chemical Communications 2019, 55 (17) , 2533-2536. https://doi.org/10.1039/C9CC00066F
    94. Nithya Velusamy, Natesan Thirumalaivasan, Kondapa Naidu Bobba, Arup Podder, Shu-Pao Wu, Sankarprasad Bhuniya. FRET-based dual channel fluorescent probe for detecting endogenous/exogenous H2O2/H2S formation through multicolor images. Journal of Photochemistry and Photobiology B: Biology 2019, 191 , 99-106. https://doi.org/10.1016/j.jphotobiol.2018.12.016
    95. Yanmei Si, Lulu Li, Xiaojie Qin, Yaocai Bai, Jishan Li, Yadong Yin. Porous SiO2-coated Au-Ag alloy nanoparticles for the alkyne-mediated ratiometric Raman imaging analysis of hydrogen peroxide in live cells. Analytica Chimica Acta 2019, 99 https://doi.org/10.1016/j.aca.2018.12.061
    96. Hui Zhou, Jinbao Tang, Lin Sun, Jie Zhang, Bochao Chen, Jianfei Kan, Weifen Zhang, Jian Zhang, Jin Zhou. H2S2-triggered off-on fluorescent indicator with endoplasmic reticulum targeting for imaging in cells and zebrafishes. Sensors and Actuators B: Chemical 2019, 278 , 64-72. https://doi.org/10.1016/j.snb.2018.09.081
    97. Fang Dai, Fang Jin, Ying Long, Xiao-Ling Jin, Bo Zhou. A 1,8-naphthalimide-based turn-on fluorescent probe for imaging mitochondrial hydrogen peroxide in living cells. Free Radical Research 2018, 52 (11-12) , 1288-1295. https://doi.org/10.1080/10715762.2018.1446530
    98. Dajun Wu, Bin Fang, Mingzhu Zhang, Wei Du, Jun Zhang, Xiaohe Tian, Qiong Zhang, Hongping Zhou, Jieying Wu, Yupeng Tian. D-A type phenanthridine derivatives with aggregation-induced enhanced emission and third-order nonlinear optical properties for bioimaging. Dyes and Pigments 2018, 159 , 142-150. https://doi.org/10.1016/j.dyepig.2018.06.024
    99. Longxue Nie, Bingpeng Guo, Congcong Gao, Shaowen Zhang, Jing Jing, Xiaoling Zhang. Specific and sensitive imaging of basal cysteine over homocysteine in living cells. RSC Advances 2018, 8 (65) , 37410-37416. https://doi.org/10.1039/C8RA05908J
    100. Jingli Hou, Meng Qian, Huanhuan Zhao, Yingchun Li, Yongfang Liao, Guifang Han, Zhelong Xu, Feng Wang, Yuguang Song, Yangping Liu. A near-infrared ratiometric/turn-on fluorescent probe for in vivo imaging of hydrogen peroxide in a murine model of acute inflammation. Analytica Chimica Acta 2018, 1024 , 169-176. https://doi.org/10.1016/j.aca.2018.03.028
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