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Protective Effects of Catechin against Monosodium Urate-Induced Inflammation through the Modulation of NLRP3 Inflammasome Activation

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† Department of Food Science and Biotechnology, National Chung Hsing University, 250 Kuokuang Road, Taichung 40227, Taiwan
‡ Agricultural Biotechnology Center, National Chung Hsing University, Taichung 40227, Taiwan
*Phone: 886-4-2287-9755. Fax: 886-4-2285-4378, E-mail: [email protected]
Cite this: J. Agric. Food Chem. 2015, 63, 33, 7343–7352
Publication Date (Web):August 1, 2015
https://doi.org/10.1021/acs.jafc.5b02605
Copyright © 2015 American Chemical Society
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    Abstract

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    Gouty inflammation results from the stimulation of monosodium urate (MSU). Interleukin-1β (IL-1β) secretion is the primary clinical manifestation of MSU attack, and MSU activates IL-1β through a nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome. This study investigated the protective effect and underlying mechanism of naturally occurring phenolic compounds on MSU-induced inflammation in vivo and in vitro. A screening of phenolic compounds revealed that gallic acid and catechin exhibited the most potent free radical scavenging activities. Subcutaneous injection of gallic acid or catechin significantly reduced MSU-induced IL-1β and IL-6 secretion in C57BL/6 mice. However, only catechin inhibited MSU-induced IL-1β secretion and NLRP3 inflammasome activation in MSU-challenged THP-1 cells. MSU-triggered mitochondrial reactive oxygen species (MtROS) production and intracellular calcium levels were significantly decreased by treatment with catechin in THP-1 cells. Catechin treatment also up-regulated Bcl-2 levels and restored MSU-induced mitochondrial transmembrane potential impairment. These results indicate that the protective effects of catechin on MSU-induced IL-1β secretion are associated with modulation of mitochondrial damage. It also suggests that catechin has the potential to protect gout attack by modulation of NLRP3 inflammasome activation.

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.jafc.5b02605.

    • Effects of gallic acid and catechin on NF-κB signaling in THP-1 cells; effects of gallic acid and catechin on phagocytosis and lysosomal function in THP-1 cells; effects of gallic acid and catechin on superoxide anion and ROS; effects of gallic acid and catechin on glutathione (PDF)

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    9. Xiao Liang, Jingjing Cai, Yuchao Fan. Causal association between tea intake and risk for gout: a Mendelian randomization study. Frontiers in Genetics 2023, 14 https://doi.org/10.3389/fgene.2023.1220931
    10. Tarique Hussain. Antioxidant Strategies to Improve Female Reproduction. 2023https://doi.org/10.5772/intechopen.110639
    11. Hui Liu, Hui Guan, Fatao He, Ye Song, Feng Li, Dongxiao Sun-Waterhouse, Dapeng Li. Therapeutic actions of tea phenolic compounds against oxidative stress and inflammation as central mediators in the development and progression of health problems: A review focusing on microRNA regulation. Critical Reviews in Food Science and Nutrition 2023, 17 , 1-31. https://doi.org/10.1080/10408398.2023.2202762
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    13. Anna Scanu, Roberto Luisetto, Roberta Ramonda, Paolo Spinella, Paolo Sfriso, Paola Galozzi, Francesca Oliviero. Anti-Inflammatory and Hypouricemic Effect of Bioactive Compounds: Molecular Evidence and Potential Application in the Management of Gout. Current Issues in Molecular Biology 2022, 44 (11) , 5173-5190. https://doi.org/10.3390/cimb44110352
    14. Mi Zhou, Ying Zhang, Zhan Zhang, Xiaojie Ding, Yue Luo, Xiaoya Fei, Jiankun Song, Dan Yang, Siting Chen, Bin Li, Le Kuai. Identification of the potential mechanisms of Huzhang Tongfeng Granules against acute gouty arthritis through network pharmacology and in vivo analysis. Pharmacological Research - Modern Chinese Medicine 2022, 4 , 100131. https://doi.org/10.1016/j.prmcm.2022.100131
    15. Chen Chen, Jingyun Wang, Zhihui Liang, Min Li, Duo Fu, Lei Zhang, Xuecheng Yang, Yiyang Guo, Dan Ge, Yang Liu, Bingbing Sun. Monosodium urate crystals with controlled shape and aspect ratio for elucidating the pathological progress of acute gout. Biomaterials Advances 2022, 139 , 213005. https://doi.org/10.1016/j.bioadv.2022.213005
    16. Jianan Zhao, Kai Wei, Ping Jiang, Cen Chang, Lingxia Xu, Linshuai Xu, Yiming Shi, Shicheng Guo, Yu Xue, Dongyi He. Inflammatory Response to Regulated Cell Death in Gout and Its Functional Implications. Frontiers in Immunology 2022, 13 https://doi.org/10.3389/fimmu.2022.888306
    17. Chenxi Wu, Fenfen Li, Xiaoxi Zhang, Wenjing Xu, Yan Wang, Yanjing Yao, Ziwei Han, Daozong Xia. (−)-Epicatechin Ameliorates Monosodium Urate-Induced Acute Gouty Arthritis Through Inhibiting NLRP3 Inflammasome and the NF-κB Signaling Pathway. Frontiers in Pharmacology 2022, 13 https://doi.org/10.3389/fphar.2022.799552
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    29. Brice Ayissi Owona, Wilfred Angie Abia, Paul Fewou Moundipa. Natural compounds flavonoids as modulators of inflammasomes in chronic diseases. International Immunopharmacology 2020, 84 , 106498. https://doi.org/10.1016/j.intimp.2020.106498
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    32. Elena-Valeria Fuior, Manuela Calin. Nanoparticle-based delivery of polyphenols for the treatment of inflammation-associated diseases. 2020, 343-382. https://doi.org/10.1016/B978-0-12-819666-3.00012-2
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    35. Xiaohui Lu, Runming Zeng, Jing Lin, Jun Hu, Zhijie Rong, Weicai Xu, Zewa Liu, Wanting Zeng. Pharmacological basis for use of madecassoside in gouty arthritis: anti-inflammatory, anti-hyperuricemic, and NLRP3 inhibition. Immunopharmacology and Immunotoxicology 2019, 41 (2) , 277-284. https://doi.org/10.1080/08923973.2019.1590721
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    37. Chia-Chun Tseng, Chung-Jen Chen, Jeng-Hsien Yen, Hsi-Yuan Huang, Jan-Gowth Chang, Shun-Jen Chang, Wei-Ting Liao. Next-generation sequencing profiling of mitochondrial genomes in gout. Arthritis Research & Therapy 2018, 20 (1) https://doi.org/10.1186/s13075-018-1637-5
    38. Pauline Chalons, Souheila Amor, Flavie Courtaut, Emma Cantos-Villar, Tristan Richard, Cyril Auger, Philippe Chabert, Valérie Schni-Kerth, Virginie Aires, Dominique Delmas. Study of Potential Anti-Inflammatory Effects of Red Wine Extract and Resveratrol through a Modulation of Interleukin-1-Beta in Macrophages. Nutrients 2018, 10 (12) , 1856. https://doi.org/10.3390/nu10121856
    39. Francis Herman, Susan Westfall, Justin Brathwaite, Giulio M. Pasinetti. Suppression of Presymptomatic Oxidative Stress and Inflammation in Neurodegeneration by Grape-Derived Polyphenols. Frontiers in Pharmacology 2018, 9 https://doi.org/10.3389/fphar.2018.00867
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    41. Naoto Hashimoto, Kyu-Ho Han, Michihiro Fukushima. Intraduodenal infusion of cyanidin-3-glucoside transiently promotes triglyceride excretion into bile in rats. Nutrition Research 2017, 38 , 34-42. https://doi.org/10.1016/j.nutres.2017.01.002
    42. Jhih‐Jia Jhang, Chi‐Cheng Lu, Gow‐Chin Yen. Epigallocatechin gallate inhibits urate crystals‐induced peritoneal inflammation in C57BL/6 mice. Molecular Nutrition & Food Research 2016, 60 (10) , 2297-2303. https://doi.org/10.1002/mnfr.201600106
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