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Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins

Oncogene volume 20, pages 6638–6642 (2001)Cite this article

Abstract

Transcriptional coactivators SRC-1 and p300 specifically interact with liganded-nuclear receptors and also modulate other transcription factors, including serum response factor (SRF). Here, we report that retinoids repress transactivation by SRF and specific interactions exist between the DNA binding domains of SRF and retinoic acid and retinoid X receptors. We further demonstrate that the repression may involve retinoid-dependent competition for a limiting amount of SRC-1 and p300 between SRF and retinoid receptors. We propose that the well-defined anti-proliferative action of retinoids could, at least in part, result from this novel transrepressive action on the mitogenic transcription factor SRF.

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Acknowledgements

We thank Drs Larry Jameson and Richard Treisman for plasmids. This research was exclusively supported by a grant from the National Creative Research Initiatives Program of the Korean Ministry of Science and Technology.

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Authors and Affiliations

  1. Center for Ligand and Transcription, Pohang University of Science and Technology, Pohang, 790-784, Korea

    Seung-Whan Kim, Han-Jong Kim, Dong-Ju Jung, Soo-Kyung Lee, Youn-Sung Kim & Jae Woon Lee

  2. College of Pharmacy, Chonnam National University, Kwangju, 500-757, Korea

    Tae Sung Kim

  3. Gene Expression Laboratory, Salk Institute of Biological Sciences, San Diego, CA 92037, California, USA

    Soo-Kyung Lee

  4. Department Life Science, Kwangju Institute of Science and Technology, Kwangju, 506-303, Korea

    Jae Hong Kim

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  1. Seung-Whan Kim
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Correspondence to Jae Woon Lee.

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Kim, SW., Kim, HJ., Jung, DJ. et al. Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins. Oncogene 20, 6638–6642 (2001). https://doi.org/10.1038/sj.onc.1204695

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