The Role of Melatonin in Palliative Care #306

National Institutes of Health: Dietary Supplements: What You Need to Know. NIH, 2011. ods.od.nih.gov/HealthInformation/DS_WhatYouNeedToKnow.aspx. (Last accessed June 10, 2015.)

Sánchez-Barceló EJ, Mediavilla MD, Reiter RJ: Clinical uses of melatonin in pediatrics. Int J Pediatr 2011;2011:892624.

Axelrod J, Shein HM, Wurtman RJ: Stimulation of C14-melatonin synthesis from C14-tryptophan by noradrenaline in rat pineal in organ culture. Proc Natl Acad Sci USA 1969;62:544–549.

Mahmoud F, Sarhill N, Mazurczak MA: The therapeutic application of melatonin in supportive care and palliative medicine. Am J Hosp Palliat Care 2005;22:295–309.

Di WL, Kadva A, Johnston A, Silman R: Variable bioavailability of oral melatonin. N Engl J Med 1997;336:1028–1029.

Harpsøe NG, Andersen LP, Gögenur I, Rosenberg J: Clinical pharmacokinetics of melatonin: A systematic review. Eur J Clin Pharmacol 2015. (E-pub ahead of print.)

Buscemi N, Vandermeer B, Hooton N, et al.: The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis. J Gen Intern Med 2005;20:1151–1158.

McCleery J, Cohen DA, Sharpley AL: Pharmacotherapies for sleep disturbances in Alzheimer's disease. Cochrane Database Syst Rev 2014;3:CD009178.

Xu J, Wang LL, Dammer EB, et al.: Melatonin for sleep disorders and cognition in dementia: A meta-analysis of randomized controlled trials. Am J Alzheimers Dis Other Demen 2015. [E-pub ahead of print.]

Wang YM, Jin BZ, Ai F, et al.: The efficacy and safety of melatonin in concurrent chemotherapy or radiotherapy for solid tumors: A meta-analysis of randomized controlled trials. Cancer Chemother Pharmacol 2012;69:1213–1220.

Sookprasert A, Johns NP, Phunmanee A, et al.: Melatonin in patients with cancer receiving chemotherapy: A randomized, double-blind, placebo-controlled trial. Anticancer Res 2014;34:7327–7337.

Hanania M, Kitain E: Melatonin for treatment and prevention of postoperative delirium. Anesth Analg 2002;94:338–339.

Al-Aama R, Brymer C, Gutmanis I, et al.: Melatonin decreases delirium in elderly patients: A randomized, placebo-controlled trial. In J Geriatr Psychiatry 2011;26:687–694.

Hatta K, Kishi Y, et al.: Preventive effects of ramelteon on delirium: A randomized placebo controlled trial. JAMA Psychiatry 2014;71:397–403.

Fildes JE, Yonan N, Keevil BG: Melatonin: A pleiotropic molecule involved in pathophysiological processes following organ transplantation. Immunology 2009;127:443–449.