Enhancing Gene Targeting with Designed Zinc Finger Nucleases

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We are extremely grateful to K. Golic and his group, particularly M. Golic, Y. Rong, and W. Gong, for fly stocks, the donor vector, hospitality, communication of results in advance of publication, and advice. We thank D. Segal and C. Barbas for providing the zinc finger coding sequences from which the yA and yB combinations were constructed. J. Staton contributed to the analysis of the germline y mutants. K.B. was supported by a postdoctoral fellowship from the NIH, and the workwas made possible by a research grant from the National Institute of General Medical Sciences to D.C. (GM58504). Partial support was also provided by a center support grant from the National Cancer Institute.