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Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

Donald R. Senger, Stephen J. Galli, Ann M. Dvorak, Carole A. Perruzzi, V. Susan Harvey, and Harold F. DvorakAuthors Info & Affiliations
Science
25 Feb 1983
Vol 219, Issue 4587
pp. 983-985
DOI: 10.1126/science.6823562
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Abstract

Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability. Similar activity is also secreted by these tumor cells and a variety of other tumor cell lines in vitro. The permeability-increasing activity purified from either the culture medium or ascites fluid of one tumor, the guinea pig line 10 hepatocarcinoma, is a 34,000- to 42,000-dalton protein distinct from other known permeability factors.

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Science
Volume 219 | Issue 4587
25 February 1983

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© 1983.

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Published in print: 25 February 1983

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Authors

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Donald R. Senger
Departments of Pathology, Beth Israel Hospital, and Harvard Medical School, and Charles A. Dana Research Institute, Beth Israel Hospital, Boston, Massachusetts 02215
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Stephen J. Galli
Departments of Pathology, Beth Israel Hospital, and Harvard Medical School, and Charles A. Dana Research Institute, Beth Israel Hospital, Boston, Massachusetts 02215
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Ann M. Dvorak
Departments of Pathology, Beth Israel Hospital, and Harvard Medical School, and Charles A. Dana Research Institute, Beth Israel Hospital, Boston, Massachusetts 02215
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Carole A. Perruzzi
Departments of Pathology, Beth Israel Hospital, and Harvard Medical School, and Charles A. Dana Research Institute, Beth Israel Hospital, Boston, Massachusetts 02215
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V. Susan Harvey
Departments of Pathology, Beth Israel Hospital, and Harvard Medical School, and Charles A. Dana Research Institute, Beth Israel Hospital, Boston, Massachusetts 02215
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Harold F. Dvorak
Departments of Pathology, Beth Israel Hospital, and Harvard Medical School, and Charles A. Dana Research Institute, Beth Israel Hospital, Boston, Massachusetts 02215
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  • Donald R. Senger et al.
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Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid.Science219,983-985(1983).DOI:10.1126/science.6823562

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