High Expression of Macrophage Colony-Stimulating Factor in Peritumoral Liver Tissue Is Associated With Poor Survival After Curative Resection of Hepatocellular Carcinoma
Publication: Journal of Clinical Oncology
Abstract
Purpose
To investigate prognostic values of the intratumoral and peritumoral expression of macrophage colony-stimulating factors (M-CSF) in hepatocellular carcinoma (HCC) patients after curative resection.
Patients and Methods
Expression of M-CSF and density of macrophages (MΦ) were assessed by immunohistochemistry in tissue microarrays containing paired tumor and peritumoral liver tissue from 105 patients who had undergone hepatectomy for histologically proven HCC. Prognostic value of these and other clinicopathologic factors was evaluated.
Results
Neither intratumoral M-CSF nor MΦ density was associated with overall survival (OS) or disease-free survival (DFS). High peritumoral M-CSF and MΦ density, which correlated with large tumor size, presence of intrahepatic metastasis, and high TNM stage, were independent prognostic factors for both OS (P = .001 and P < .001, respectively) and DFS (P = .001 and P = .003, respectively) and affected incidence of early recurrence. In a small HCC subset, peritumoral M-CSF was also correlated with both OS and DFS (P = .038 and P = .001, respectively). The combination of peritumoral M-CSF and MΦ had a better power to predict the patients' death and disease recurrence (P < .001 for both).
Conclusion
High peritumoral M-CSF and MΦ were associated with HCC progression, disease recurrence, and poor survival after hepatectomy, highlighting the importance of peritumoral tissue in the recurrence and metastasis of HCC. M-CSF and MΦ may be targets of postoperative adjuvant therapy.
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High Expression of Macrophage Colony-Stimulating Factor in Peritumoral Liver Tissue Is Associated With Poor Survival After Curative Resection of Hepatocellular Carcinoma
J Clin Oncol Zhu et al. 26:2707
J Clin Oncol Zhu et al. 26:2707
Publisher’s Note
The June 1, 2008, article by Zhu et al entitled, “High Expression of Macrophage Colony-Stimulating Factor in Peritumoral Liver Tissue Is Associated With Poor Survival After Curative Resection of Hepatocellular Carcinoma” (J Clin Oncol 26:2707–2716, 2008) was published online May 28, 2008 with errors. In parts C and D of Figure 2, the results were labeled “low peritumoral M-CSF” and “high peritumoral M-CSF,” whereas they should have been labeled “low intratumoral M-CSF” and “high intratumoral M-CSF” respectively.
This has been corrected as of July 29, 2008.
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© 2008 by American Society of Clinical Oncology.
History
Published in print: June 01, 2008
Published online: September 21, 2016
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Article Citation
High Expression of Macrophage Colony-Stimulating Factor in Peritumoral Liver Tissue Is Associated With Poor Survival After Curative Resection of Hepatocellular Carcinoma. JCO 26, 2707-2716(2008).
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Journal of Clinical Oncology 2008 26:16, 2707-2716
Journal of Clinical Oncology 2008 26:16, 2707-2716
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