MicroRNAs in Cancer: Small Molecules With a Huge Impact
Publication: Journal of Clinical Oncology
Abstract
Every cellular process is likely to be regulated by microRNAs, and an aberrant microRNA expression signature is a hallmark of several diseases, including cancer. MicroRNA expression profiling has indeed provided evidence of the association of these tiny molecules with tumor development and progression. An increasing number of studies have then demonstrated that microRNAs can function as potential oncogenes or oncosuppressor genes, depending on the cellular context and on the target genes they regulate. Here we review our current knowledge about the involvement of microRNAs in cancer and their potential as diagnostic, prognostic, and therapeutic tools.
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Authors' Disclosures of Potential Conflicts of Interest
The author(s) indicated no potential conflicts of interest.
Information & Authors
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© 2009 by American Society of Clinical Oncology.
History
Published online: November 02, 2009
Published in print: December 01, 2009
Authors
Author Contributions
Conception and design: Carlo M. Croce
Manuscript writing: Marilena V. Iorio, Carlo M. Croce
Final approval of manuscript: Carlo M. Croce
Funding Information
Supported by grants from the National Cancer Institute (C.M.C.), and a My First AIRC Grant from Associazione Italiana per la Ricerca sul Cancro (M.V.I.).
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Article Citation
MicroRNAs in Cancer: Small Molecules With a Huge Impact. JCO 27, 5848-5856(2009).
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Journal of Clinical Oncology 2009 27:34, 5848-5856
Journal of Clinical Oncology 2009 27:34, 5848-5856
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