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Expression of genes belonging to the IGF-system in glial tumors

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Abstract

Increased expression of the insulin-like growth factor (IGF) family members, IGF1, IGF2, their receptors and binding proteins, or combinations thereof has been documented in various malignancies including gliomas. The results of multiple investigations suggest that the IGFs can play a paracrine and/or autocrine role in promoting tumor growth in situ during tumor progression but that these roles may vary depending on the tissue of origin. Enhanced IGF1 expression was not found in glioblastomas and it was supposed that IGF1 participation in the development of glial tumors may be substituted by protein products of highly expressed other genes, also participating in PI3K and MAPK pathways. Increased expression of IGF-binding protein genes in brain tumors makes the picture even more complicated. As other binding proteins, IGFBPs regulate the activity of their ligands by prolonging their half-life. The discrepancies arising from conflicting evidence on the results obtained by different laboratories in human gliomas are discussed. Our data highlight the importance of viewing the IGF-related proteins as a complex multifactorial system and show that changes in the expression levels of any one component of the system, in a given malignancy, should be interpreted with caution. As IGF targeting for anticancer therapy is rapidly becoming clinical reality, an understanding of this complexity is very timely.

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References

  1. Friedrichs, N., Kuchler, J., Endl, E., Koch, A., Czerwitzki, J., Wurst, P., Metzger, D., Schulte, J.H., Holst, M.I., Heukamp, L.C., Larsson, O., Tanaka, S., Kawai, A., Wardelmann, E., Buettner, R., Pietsch, T., and Hartmann, W., Insulin-Like Growth Factor-1 Receptor Acts as a Growth Regulator in Synovial Sarcoma, J. Pathol., 2008, vol. 216, no. 4, pp. 428–439.

    Article  PubMed  CAS  Google Scholar 

  2. Eckstein, N., Servan, K., Hildebrandt, B., Politz, A., von Jonquieres, G., Wolf-Kummeth, S., Napierski, I., Hamacher, A., Kassack, M.U., Budczies, J., Beier, M., Dietel, M., Royer-Pokora, B., Denkert, C., and Royer, H.D., Hyperactivation of the Insulin-Like Growth Factor Receptor I Signaling Path-Way Is an Essential Event for Cisplatin Resistance of Ovarian Cancer Cells, Cancer Res., 2009, vol. 69, no. 7, pp. 2996–3003.

    Article  PubMed  CAS  Google Scholar 

  3. Ma, J., Sawai, H., Matsuo, Y., Ochi, N., Yasuda, A., Takahashi, H., Wakasugi, T., Funahashi, H., Sato, M., and Takeyama, H., IGF-1 Mediates PTEN Suppression and Enhances Cell Invasion and Proliferation via Activation of the IGF-1/PI3K/Akt Signaling Pathway in Pancreatic Cancer Cells, J. Surg. Res., 2010, vol. 160, no. 1, pp. 90–101.

    Article  PubMed  CAS  Google Scholar 

  4. Samani, A.A., Yakar, S., LeRoith, D., and Brodt, P., The Role of the IGF System in Cancer Growth and Metastasis: Overview and Recent Insights, Endocr. Rev., 2007, vol. 28, no. 1, pp. 20–47.

    Article  PubMed  CAS  Google Scholar 

  5. Sandberg, A.C., Engberg, C., Lake, M., von Holst, H., and Sara, V.R., The Expression of Insulin-Like Growth Factor I and Insulin-Like Growth Factor II Genes in the Human Fetal and Adult Brain and in Glioma, Neurosci. Lett., 1988, no. 1, pp. 114–119.

  6. Sandberg-Nordqvist, A.C., Stahlbom, P.A., Reinecke, M., Collins, V.P., von Holst, H., and Sara, V., Characterization of Insulin-Like Growth Factor 1 in Human Primary Brain Tumors, Cancer Res., 1993, vol. 53, no. 11, pp. 2475–2478.

    PubMed  CAS  Google Scholar 

  7. Antoniades, H.N., Galanopoulos, T., Neville-Golden, J., and Maxwell, M., Expression of Insulin-Like Growth Factors I and II and Their Receptor mRNAs in Primary Human Astrocytomas and Meningiomas; in vivo Studies using in situ Hybridization and Immunocytochemistry, Int. J. Cancer, 1992, vol. 50, no. 2, pp. 215–222.

    Article  PubMed  CAS  Google Scholar 

  8. Hirano, H., Lopes, M.B., Laws, JrE.R., Asakura, T., Goto, M., Carpenter, J.E., Karns, L.R., and Vanden Berg, S.R., Insulinlike Growth Factor-1 Content and Pattern of Expression Correlates with Histopathologic Grade in Diffusely Infiltrating Astrocytomas, Neuro Oncol., 1999, vol. 1, no. 2, pp. 109–119.

    PubMed  CAS  Google Scholar 

  9. Lichtor, T., Kurpakus, M.A., and Gurney, M.E., Differential E Pression of Insulin-Like Growth Factor II in Human Meningiomas, Neurosurgery, 1991, vol. 29, no. 3, pp. 405–409.

    Article  PubMed  CAS  Google Scholar 

  10. Glick, R.P., Unterman, T.G., and Lacson, R., Identification of Insulin-Like Growth Factor (IGF) and Glucose Trans-Porter-1 and -3 mRNA in CNS Tumors, Regul. Pept., 1993, vol. 48, nos. 1/2, pp. 251–256.

    Article  PubMed  CAS  Google Scholar 

  11. Kavsan, V., Shostak, K., Dmitrenko, V., Zozulya, Y., and Rozumenko, V., Demotes-Mainard J. Characterization of Genes with Increased Expression in Human Glioblastomas, Cytol. Genet., 2005, vol. 39, no. 1, pp. 37–49.

    CAS  Google Scholar 

  12. De Tayrac, M., Etcheverry, A., Aubry, M., Sakali, S., Hamlat, A., Quillien, V., Le Treut, A., Galibert, M.D., and Mosser, J., Integrative Genome-Wide Analysis Reveals a Robust Genomic Glioblastoma Signature Associated with Copy Number Driving Changes in Gene Expression, Genes Chromosomes Cancer, 2009, vol. 48, no. 1, pp. 55–68.

    Article  PubMed  Google Scholar 

  13. Verhaak, R.G., Hoadley, K.A., Purdom, E., Wang, V., Qi, Y., Wilkerson, M.D., Miller, C.R., Ding, L., Golub, T., Mesirov, J.P., Alexe, G., Lawrence, M., Kelly, M., Tamayo, P., Weir, B.A., Gabriel, S., Winckler, W., Gupta, S., Jakkula, L., Feiler, H.S., Hodgson, J.G., James, C.D., Sarkaria, J.N., Brennan, C., Kahn, A., Spellman, P.T., Wilson, R.K., Speed, T.P., Gray, J.W., Meyerson, M., Getz, G., Perou, C.M., and Hayes, D.N., Cancer Genome Atlas Research Network. Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1, Cancer Cell, 2010, vol. 17, no. 1, pp. 98–110.

    Article  PubMed  CAS  Google Scholar 

  14. Kim, H.S., Nagalla, S.R., Oh, Y., Wilson, E., Roberts, C.T., and Rosenfeld, R.G., Identification of a Family of Low-Affinity Insulin-Like Growth Factor Binding Proteins (IGFBPs): Characterization of Connective Tissue Growth Factor As a Member of the IGFBP Superfamily, Proc. Natl. Acad. Sci. USA, 1997, vol. 94, no. 24, pp. 12981–12986.

    Article  PubMed  CAS  Google Scholar 

  15. Collett-Solberg, P.F. and Cohen, P., Genetics, Chemistry, and Function of the IGF/IGFBP System, Endocrine, 2000, vol. 12, no. 2, pp. 121–136.

    Article  PubMed  CAS  Google Scholar 

  16. Mohan, S. and Baylink, D.J., IGF-Binding Proteins Are Multifunctional and Act Via IGF-dependent and — Independent Mechanisms, J. Endocrinol., 2002, vol. 175, no. 1, pp. 19–31.

    Article  PubMed  CAS  Google Scholar 

  17. Louis, D.N., Ohgaki, H., Wiestler, O.D., Cavenee, W.K., Burger, P.C., Jouvet, A., Scheithauer, B.W., and Kleihues, P., The 2007 WHO Classification of Tumours of the Central Nervous System, Acta Neuropathol., 2007, vol. 114, no. 2, pp. 97–109.

    Article  PubMed  Google Scholar 

  18. Kavsan, V.M., Dmitrenko, V.V., Shostak, K.O., Bukreieva, T.V., Vitak, N.Y., Simirenko, O.E., Malisheva, T.A., Shamayev, M.I., Rozumenko, V.D., and Zozulya, Y.A., Comparison of Microarray and SAGE Techniques in Gene Expression Analysis of Human Glioblastoma, Cytol. Genet., 2007, vol. 41, no. 1, pp. 36–55.

    Article  CAS  Google Scholar 

  19. Ritz, C. and Spiess, A.N., QpcR: An R Package for Sigmoidal Model Selection in Quantitative Real-Time Polymerase Chain Reaction Analysis, Bioinformatics, 2008, vol. 24, no. 13, pp. 1549–1551.

    Article  PubMed  CAS  Google Scholar 

  20. Livak, K.J. and Schmittgen, T.D., Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2 (-Delta Delta C (T)) Method, Methods, 2001, vol. 25, no. 4, pp. 402–408.

    Article  PubMed  CAS  Google Scholar 

  21. Freije, W.A., Castro-Vargas, F.E., Fang, Z., Horvath, S., Cloughesy, T., Liau, L.M., Mischel, P.S., and Nelson, S.F., Gene Expression Profiling of Gliomas Strongly Predicts Survival, Cancer Res., 2004, no. 18, pp. 6503–6510.

  22. Phillips, H.S., Kharbanda, S., Chen, R., Forrest, W.F., Soriano, R.H., Wu, T.D., Misra, A., Nigro, J.M., Colman, H., Soroceanu, L., Williams, P.M., Modrusan, Z., Feuerstein, B.G., and Aldape, K., Molecular Subclasses of High-Grade Glioma Predict Prognosis, Delineate a Pattern of Disease Progression, and Resemble Stages in Neurogenesis, Cancer Cell, 2006, vol. 9, no. 3, pp. 157–173.

    Article  PubMed  CAS  Google Scholar 

  23. Ge, X., Yamamoto, S., Tsutsumi, S., Midorikawa, Y., Ihara, S., Wang, S.M., and Aburatani, H., Interpreting Expression Profiles of Cancers by Genome-Wide Survey of Breadth of Expression in Normal Tissues, Genomics, 2005, vol. 86, no. 2, pp. 127–141.

    Article  PubMed  CAS  Google Scholar 

  24. Sun, L., Hui, A.M., Su, Q., Vortmeyer, A., Kotliarov, Y., Pastorino, S., Passaniti, A., Menon, J., Walling, J., Bailey, R., Rosenblum, M., Mikkelsen, T., and Fine, H.A., Neuronal and Glioma-Derived Stem Cell Factor Induces Angiogenesis within the Brain, Cancer Cell, 2006, vol. 9, no. 4, pp. 287–300.

    Article  PubMed  CAS  Google Scholar 

  25. Liu, T., Papagiannakopoulos, T., Puskar, K., Qi, S., Santiago, F., Clay, W., Lao, K., Lee, Y., Nelson, S.F., Kornblum, H.I., Doyle, F., Petzold, L., Shraiman, B., and Kosik, K.S., Detection of a MicroRNA Signal in an in vivo Expression Set of mRNAs, PLoS One, 2007, vol. 2, no. 8, p. e804.

    Article  PubMed  Google Scholar 

  26. Su, A.I., Wiltshire, T., Batalov, S., Lapp, H., Ching, K.A., Block, D., Zhang, J., Soden, R., Hayakawa, M., Kreiman, G., Cooke, M.P., Walker, J.R., and Hogenesch, J.B., A Gene Atlas of the Mouse and Human Protein-Encoding Transcriptomes, Proc. Natl. Acad. Sci. USA, 2004, vol. 101, no. 16, pp. 6062–6067.

    Article  PubMed  CAS  Google Scholar 

  27. Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., and Speleman, F., Accurate Normalization of Real-Time Quantitative RT-PCR Data by Geometric Averaging of Multiple Internal Control Genes, Genome Biol., 2002, vol. 3, no. 7, p. RESEARCH0034.

    Article  PubMed  Google Scholar 

  28. Weroha, S.J. and Haluska, P., IGF-1 Receptor Inhibitors in Clinical Trials-Early Lessons, J. Mammary Gland Biol. Neoplasia, 2008, vol. 13, no. 4, pp. 471–483.

    Article  PubMed  Google Scholar 

  29. Denley, A., Wallace, J.C., Cosgrove, L.J., and Forbes, B.E., The Insulin Receptor Isoform Exon 11 (IR-A) in Cancer and Other Diseases: a Review, Horm. Metab. Res., 2003, vol. 35, nos. 11/12, pp. 778–785.

    PubMed  CAS  Google Scholar 

  30. Pietrzkowski, Z., Mulholland, G., Gomella, L., Jameson, B.A., Wernicke, D., and Baserga, R., Inhibition of Growth of Prostatic Cancer Cell Lines by Peptide Analogues of Insulin-Like Growth Factor 1, Cancer Res., 1993, vol. 53, no. 5, pp. 1102–1106.

    PubMed  CAS  Google Scholar 

  31. Rininsland, F., Johnson, T.R., Chernicky, C.L., Schulze, E., Burfeind, P., and Ilan, J., Suppression of Insulin-Like Growth Factor Type I Receptor by a Triple-Helix Strategy Inhibits IGF-I Transcription and Tumorigenic Potential of Rat C6 Glioblastoma Cells, Proc. Natl. Acad. Sci. USA, 1997, vol. 94, no. 11, pp. 5854–5859.

    Article  PubMed  CAS  Google Scholar 

  32. Trojan, J., Johnson, T.R., Rudin, S.D., Ilan, J., and Tykocinski, M.L., Treatment and Prevention of Rat Glioblastoma by Immunogenic C6 Cells Expressing Antisense Insulin-Like Growth Factor I RNA, Science, 1993, vol. 259, no. 5091, pp. 94–97.

    Article  PubMed  CAS  Google Scholar 

  33. Trojan, J., Cloix, J.F., Ardourel, M.Y., Chatel, M., and Anthony, D.D., Insulin-Like Growth Factor Type I Biology and Targeting in Malignant Gliomas, Neuro-science, 2007, vol. 145, no. 3, pp. 795–811.

    CAS  Google Scholar 

  34. Dmitrenko, V.V., Bukreeva, T.V., Shostak, K.O., Vitak, N.Y., Pekarsky, Y.A., Malisheva, T.A., Shamayev, M.I., Rozumenko, V.D., Kondratyuk, V.V., Zozulya, Y.P., and Kavsan, V.M., Extraordinary High Content of mRNA of IGF-II-Associated Protein in Meningiomas, Ukr. Biochem. J., 2007, vol. 79, no. 1, pp. 55–61.

    CAS  Google Scholar 

  35. Nordqvist, A.C., Peyrard, M., Pettersson, H., Mathiesen, T., Collins, V.P., Dumanski, J.P., and Schalling, M., A High Ratio of Insulin-Like Growth Factor II/Insulin-Like Growth Factor Binding Protein 2 Messenger RNA As a Marker for Anaplasia in Meningiomas, Cancer Res., 1997, vol. 57, no. 13, pp. 2611–2614.

    PubMed  CAS  Google Scholar 

  36. Schlenska-Lange, A., Knüpfer, H., Lange, T.J., Kiess, W., and Knüpfer, M. Cell Proliferation and Migration in Glioblastoma Multiforme Cell Lines Are Influenced by Insulin-Like Growth Factor I in vitro, Anticancer Res., 2008, vol. 28, no. 2a, pp. 1055–1060.

    PubMed  CAS  Google Scholar 

  37. Soroceanu, L., Kharbanda, S., Chen, R., Soriano, R.H., Aldape, K., Misra, A., Zha, J., Forrest, W.F., Nigro, J.M., Modrusan, Z., Feuerstein, B.G., and Phillips, H.S. Identification of IGF2 Signaling through Phosphoinositide-3-Kinase Regulatory Subunit 3 as a Growth-Promoting Axis in Glioblastoma, Proc. Natl. Acad. Sci. USA, 2007, vol. 104, no. 9, pp. 3466–3471.

    Article  PubMed  CAS  Google Scholar 

  38. Sara, V.R., Prisell, P., Sjogren, B., Persson, L., Boethius, J., and Enberg, G., Enhancement of Insulin-Like Growth Factor 2 Receptors in Glioblastoma, Cancer Lett., 1986, vol. 32, no. 3, pp. 229–234.

    Article  PubMed  CAS  Google Scholar 

  39. Gammeltoft, S., Ballotti, R., Kowalski, A., Westermark, B., and Van Obberghen, E., Expression of Two Types of Receptor for Insulin-Like Growth Factors in Human Malignant Glioma, Cancer Res., 1988, vol. 48, no. 5, pp. 1233–1237.

    PubMed  CAS  Google Scholar 

  40. Shostak, K., Labunskyy, V., Dmitrenko, V., Malisheva, T., Shamayev, M., Rozumenko, V., Zozulya, Y., Zehetner, G., and Kavsan, V., HC Gp-39 Gene Is Upregulated in Glioblastomas, Cancer Lett., 2003, vol. 198, no. 2, pp. 203–210.

    Article  PubMed  CAS  Google Scholar 

  41. Recklies, A.D., White, C., and Ling, H., The Chitinase 3-Like Protein Human Cartilage Glycoprotein 39 (HC-Gp39) Stimulates Proliferation of Human Connective-Tissue Cells and Activates Both Extracellular Signal-Regulated Kinase- and Protein Kinase B-Mediated Signalling Pathways, Biochem. J., 2002, vol. 365, pp. 119–126.

    Article  PubMed  CAS  Google Scholar 

  42. Fuller, G.N., Rhee, C.H., Hess, K.R., Caskey, L.S., Wang, R., Bruner, J.M., Yung, W.K., and Zhang, W., Reactivation of Insulin-Like Growth Factor Binding Protein 2 Expression in Glioblastoma Multiforme: A Revelation by Parallel Gene Expression Profiling, Cancer Res., 1999, vol. 59, no. 17, pp. 4228–4232.

    PubMed  CAS  Google Scholar 

  43. Zhang, W., Wang, H., Song, S.W., and Fuller, G.N., Insulin-Like Growth Factor Binding Protein 2: Gene Expression Microarrays and the Hypothesis-Generation Paradigm, Brain Pathol., 2002, vol. 12, no. 1, pp. 87–94.

    Article  PubMed  CAS  Google Scholar 

  44. Sallinen, S.L., Sallinen, P.K., Haapasalo, H.K., Helin, H.J., Helen, P.T., Schraml, P., Kallioniemi, O.P., and Kononen, J., Identification of Differentially Expressed Genes in Human Gliomas by DNA Microarray and Tissue Chip Techniques, Cancer Res., 2000, vol. 60, no. 23, pp. 6617–6622.

    PubMed  CAS  Google Scholar 

  45. Rickman, D.S., Bobek, M.P., Misek, D.E., Kuick, R., Blaivas, M., Kurnit, D.M., Taylor, J., and Hanash, S.M., Distinctive Molecular Profiles of High-Grade and Low Grade Gliomas Based on Oligonucleotide Microarray Analysis, Cancer Res., 2001, vol. 61, no. 18, pp. 6885–6891.

    PubMed  CAS  Google Scholar 

  46. Kim, S., Dougherty, E.R., Shmulevich, I., Hess, K.R., Hamilton, S.R., Trent, J.M., Fuller, G.N., and Zhang, W., Identification of Combination Gene Sets for Glioma Classification, Mol. Cancer Ther., 2002, vol. 1, no. 13, pp. 1229–1236.

    PubMed  CAS  Google Scholar 

  47. Godard, S., Getz, G., Delorenzi, M., Farmer, P., Kobayashi, H., Desbaillets, I., Nozaki, M., Diserens, A.C., Hamou, M.F., Dietrich, P.Y., Regli, L., Janzer, R.C., Bucher, P., Stupp, R., De Tribolet, N., Domany, E., and Hegi, M.E., Classification of Human Astrocytic Gliomas on the Basis of Gene Expression: a Correlated Group of Genes with Angiogenic Activity Emerges as a Strong Predictor of Subtypes, Cancer Res., 2003, vol. 63, no. 20, pp. 6613–6625.

    PubMed  CAS  Google Scholar 

  48. Nigro, J.M., Misra, A., Zhang, L., Smirnov, I., Colman, H., Griffin, C., Ozburn, N., Chen, M., Pan, E., Koul, D., Yung, W.K., Feuerstein, B.G., and Aldape, K.D., Integrated Array-Comparative Genomic Hybridization and Expression Array Profiles Identify Clinically Relevant Molecular Subtypes of Glioblastoma, Cancer Res., 2005, vol. 65, no. 5, pp. 1678–1686.

    Article  PubMed  CAS  Google Scholar 

  49. Markert, J.M., Fuller, C.M., Gillespie, G.Y., Bubien, J.K., McLean, L.A., Hong, R.L., Lee, K., Gullans, S.R., Mapstone, T.B., and Benos, D.J., Differential Gene Expression Profiling in Human Brain Tumors, Physiol. Genom., 2001, vol. 5, no. 1, pp. 21–33.

    CAS  Google Scholar 

  50. Ljubimova, J.Y., Lakhter, A.J., Loksh, A., Yong, W.H., Riedinger, M.S., Miner, J.H., Sorokin, L.M., Ljubimov, A.V., and Black, K., Overexpression of Alpha4 Chain-Containing Laminins in Human Glial Tumors Identified by Gene Microarray Analysis, Cancer Res., 2001, vol. 61, no. 14, pp. 5601–5610.

    PubMed  CAS  Google Scholar 

  51. Pen, A., Moreno, M.J., Martin, J., and Stanimirovic, D.B., Molecular Markers of Extracellular Matrix Remodeling in Glioblastoma Vessels: Microarray Study of Laser-Captured Glioblastoma Vessels, Glia, 2007, vol. 55, no. 6, pp. 559–572.

    Article  PubMed  Google Scholar 

  52. Wang, H., Wang, H., Zhang, W., and Fuller, G.N., Overexpression of IGFBP5, But Not IGFBP3, Correlates with the Histologic Grade of Human Diffuse Glioma: a Tissue Microarray and Immunohistochemical Study, Technol. Cancer Res. Treat., 2006, vol. 5, no. 3, pp. 195–199.

    PubMed  CAS  Google Scholar 

  53. Elmlinger, M.W., Deininger, M.H., Schuett, B.S., Meyermann, R., Duffner, F., Grote, E.H., and Ranke, M.B., In Vivo Expression of Insulin-Like Growth Factor-Binding Protein-2 in Human Gliomas Increases with the Tumor Grade, Endocrinology, 2001, vol. 142, no. 4, pp. 1652–1658.

    Article  PubMed  CAS  Google Scholar 

  54. Wheatcroft, S.B. and Kearney, M.T., IGF-Dependent and IGF-Independent Actions of IGF-Binding Protein-1 And-2: Implications for Metabolic Homeostasis, Trends Endocrinol. Metab., 2009, vol. 20, no. 4, pp. 153–162.

    Article  PubMed  CAS  Google Scholar 

  55. Fukushima, T. and Kataoka, H., Roles of Insulin-Like Growth Factor Binding Protein-2 (IGFBP-2) in Glioblastoma, Anticancer Res., 2007, vol. 27, no. 6A, pp. 3685–3692.

    PubMed  CAS  Google Scholar 

  56. Dunlap, S.M., Celestino, J., Wang, H., Jiang, R., Holland, E.C., Fuller, G.N., and Zhang, W., Insulin-Like Growth Factor Binding Protein 2 Promotes Glioma Development and Progression, Proc. Natl. Acad. Sci. USA, 2007, vol. 104, no. 28, pp. 11736–11741.

    Article  PubMed  CAS  Google Scholar 

  57. Weinzimer, S.A. and Gibson, T.B., Collett-Solberg P.F., Khare A., Liu B., Cohen P. Transferrin Is An Insulin-Like Growth Factor-Binding Protein-3 Binding Protein, J. Clin. Endocrinol. Metab., 2001, vol. 86, no. 4, pp. 1806–1813.

    Article  PubMed  CAS  Google Scholar 

  58. Liu, B., Weinzimer, S.A., Gibson, T.B., Mascarenhas, D., and Cohen, P., Type Ialpha Collagen Is An IGFBP-3 Binding Protein, Growth Horm. IGF Res., 2003, vol. 13, nos. 2/3, pp. 89–97.

    Article  PubMed  Google Scholar 

  59. Ragel, B.T., Couldwell, W.T., Gillespie, D.L., and Jensen, R.L., Identification of Hypoxia-Induced Genes in a Malignant Glioma Cell Line (U-251) by CDNA Microarray Analysis, Neurosurg. Rev., 2007, vol. 30, no. 3, pp. 181–187.

    Article  PubMed  Google Scholar 

  60. Moreno, M.J., Ball, M., Andrade, M.F., McDermid, A., and Stanimirovic, D.B., Insulin-Like Growth Factor Binding Protein-4 (IGFBP-4) Is a Novel Anti-Angiogenic and Anti-Tumorigenic Mediator Secreted by Dibutyryl Cyclic AMP (DB-cAMP)-Differentiated Glioblastoma Cells, Glia, 2006, vol. 53, no. 8, pp. 845–857.

    Article  PubMed  Google Scholar 

  61. Akkiprik, M., Hu, L., Sahin, A., Hao, X., and Zhang, W., The Subcellular Localization of IGFBP5 Affects Its Cell Growth and Migration Functions in Breast Cancer, BMC Cancer, 2009, vol. 9, p. 103.

  62. Iosef, C., Vilk, G., Gkourasas, T., Lee, K.J., Chen, B.P., Fu, P., Bach, L.A., Lajoie, G., Gupta, M.B., Li, S.S., and Han, V.K., Insulin-like Growth Factor Binding Protein-6 (IGFBP-6) Interacts with DNA-End Binding Protein Ku80 to Regulate Cell Fate, Cell Signal., 2010, vol. 22, no. 7, pp. 1033–1043.

    Article  PubMed  CAS  Google Scholar 

  63. Ruan, W.J., Lin, J., Xu, E.P., Xu, F.Y., Ma, Y., Deng, H., Huang, Q., Lv, B.J., Hu, H., Cui, J., Di, M.J., Dong, J.K., and Lai, M.D., IGFBP7 Plays a Potential Tumor Suppressor Role Against Colorectal Carcinogenesis with Its Expression Associated with DNA Hypomethylation of Exon, J. Zhejiang Univ. Sci. B, 2006, vol. 7, no. 11, pp. 929–932.

    Article  PubMed  CAS  Google Scholar 

  64. Jiang, W., Xiang, C., Cazacu, S., Brodie, C., and Mikkelsen, T., Insulin-Like Growth Factor Binding Protein 7 Mediates Glioma Cell Growth and Migration, Neoplasia, 2008, vol. 10, no. 12, pp. 1335–1342.

    PubMed  CAS  Google Scholar 

  65. Chen, C.C. and Lau, L.F., Functions and Mechanisms of Action of CCN Matricellular Proteins, Int. J. Biochem. Cell Biol., 2009, vol. 41, no. 4, pp. 771–783.

    Article  PubMed  CAS  Google Scholar 

  66. Xie, D., Yin, D., Wang, H.J., Liu, G.T., Elashoff, R., Black, K., and Koeffler, H.P., Levels of Expression of CYR61 and CTGF Are Prognostic for Tumor Progression and Survival of Individuals with Gliomas, Clin. Cancer Res., 2004, vol. 10, no. 6, pp. 2072–2081.

    Article  PubMed  CAS  Google Scholar 

  67. Bleau, A.M., Planque, N., Lazar, N., Zambelli, D., Ori, A., Quan, T., Fisher, G., Scotlandi, K., and Perbal, B., Antiproliferative Activity of CCN3: Involvement of the C-Terminal Module and Post-Translational Regulation, J. Cell Biochem., 2007, vol. 101, no. 6, pp. 1475–1491.

    Article  PubMed  CAS  Google Scholar 

  68. Yin, D., Chen, W., Kelly, J., Lu, D., Ham, M., Doan, N.B., Xie, D., Wang, C., Vadgama, J., Said, J.W., Black, K.L., and Koeffler, H.P., Connective Tissue Growth Factor Associated with Oncogenic Activities and Drug Resistance in Glioblastoma Multiforme, Int. J. Cancer, 2010, vol. 127, no. 10, pp. 2257–2267.

    Article  PubMed  CAS  Google Scholar 

  69. Xie, D., Yin, D., Tong, X., Kelly, J., Mori, A., Miller, C., Black, K., Gui, D., Said, J.W., and Koeffler, H.P., Cyr61 Is Overexpressed in Gliomas and Involved in Integrin-Linked Kinase-Mediated Akt and Beta-B-Catenin-TCF/Lef Signaling Pathways, Cancer Res., 2004, vol. 64, no. 6, pp. 1987–1996.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Molecular Biology and Genetics, Kyiv, Ukraine

    V. V. Dmitrenko, V. M. Kavsan, O. I. Boyko, V. I. Rymar, A. A. Stepanenko & O. V. Balynska

  2. A.P. Romodanov Institute of Neurosurgery, Kyiv, Ukraine

    T. A. Mausheva, V. D. Rozumenko & Y. P. Zozulya

Authors
  1. V. V. Dmitrenko
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  2. V. M. Kavsan
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  3. O. I. Boyko
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  4. V. I. Rymar
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  5. A. A. Stepanenko
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  6. O. V. Balynska
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  7. T. A. Mausheva
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  8. V. D. Rozumenko
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  9. Y. P. Zozulya
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Corresponding author

Correspondence to V. V. Dmitrenko.

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The article is published in the original.

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Dmitrenko, V.V., Kavsan, V.M., Boyko, O.I. et al. Expression of genes belonging to the IGF-system in glial tumors. Cytol. Genet. 45, 303–317 (2011). https://doi.org/10.3103/S0095452711050021

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  • DOI: https://doi.org/10.3103/S0095452711050021

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