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Research article
First published May 1989

Interleukin 1 Protects against the Lethal Effects of Irradiation of Mice but has No Effect on Tumors in the Same Animals

Mary J. Dorie, Anthony C. Allison, Mohamed S. Zaghloul, and Robert F. KallmanView all authors and affiliations
Volume 191, Issue 1
https://doi.org/10.3181/00379727-191-42884

Abstract

Interleukin 1 (IL-1) is a radioprotector of bone marrow and is cytotoxic to some tumor cells. This investigation examines these two properties in the same host animals and gives evidence of radioprotection against localized x-irradiation of the head and neck region. By LD50 analyses, recombinant human IL-1 (100 ng/mouse, approximately 3 μg/kg) was found to be radioprotective against whole-body irradiation for both C3H/Km and C57BL/Ka mice. The combined potency ratio for the two strains was 1.07 (95% confidence limit: 1.02–1.12). It was also radioprotective against the injury leading to acute lethality resulting from localized head and neck irradiation of C3H/Km mice; 100 ng of IL-1/mouse produced a potency ratio of 1.05 (95 confidence limit: 1.03–1.07). However, two tumors that originated in C3H/Km mice, RIF-1 and SCCVII, showed neither in vitro nor in vivo response to IL-1. Also, there was no IL-1-induced reduction in in vivo growth of the RL 12NP lymphoma in C57BL/Ka mice.

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Published In

Volume 191, Issue 1
Pages: 23 - 29
Article first published: May 1989
Issue published: May 1989

Authors

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Mohamed S. Zaghloul1
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Department of Radiation Oncology, Stanford University Medical Center, Stanford, California 94305 and Department of Immunology Syntex Research, Palo Alto, California 94304

Notes

∗
Department of Radiation Oncology, Stanford University Medical Center, Stanford, California 94305 and Department of Immunology
1
Present address: Radiotherapy Department, National Cancer Institute, Cairo University, foum El Khalig, Cairo, Egypt.

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