Effect of vitamin A therapy on serologic responses and viral load changes after influenza vaccination in children infected with the human immunodeficiency virus

J Pediatr. 2000 Apr;136(4):550-2. doi: 10.1016/s0022-3476(00)90024-6.

Abstract

Vitamin A administered to children infected with the human immunodeficiency virus before influenza vaccination in a double-blind randomized study did not enhance vaccine serologic responses but did dampen the increase in the human immunodeficiency virus viral load 14 days after immunization (vitamin A, decrease of 0.13 +/- 0.09 log(10) copies/mL; placebo, increase of 0.14 +/- 0.08, P =.02).

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Antibodies, Viral / blood
  • Antibodies, Viral / drug effects*
  • Child
  • Child, Preschool
  • Double-Blind Method
  • Female
  • HIV Infections / immunology*
  • HIV Infections / virology*
  • HIV-1*
  • Humans
  • Influenza A virus / immunology*
  • Influenza B virus / immunology*
  • Influenza Vaccines / immunology*
  • Male
  • Time Factors
  • Vaccines, Inactivated / immunology
  • Viral Load*
  • Vitamin A / administration & dosage*

Substances

  • Antibodies, Viral
  • Influenza Vaccines
  • Vaccines, Inactivated
  • Vitamin A