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2 result(s) for 'author#Wolfgang Mueller-Klieser' within BMC

1. Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumors

   A high rate of glycolysis leading to elevated lactate content has been linked to poor clinical outcomes in patients with head and neck and cervical cancer treated with radiotherapy. Although the biological exp...

   Authors: Eric Leung, Rob A. Cairns, Naz Chaudary, Ravi N. Vellanki, Tuula Kalliomaki, Eduardo H. Moriyama, Hilda Mujcic, Brian C. Wilson, Bradly G. Wouters, Richard Hill and Michael Milosevic

   Citation: BMC Cancer 2017 17:418

   Content type: Research article Published on: 15 June 2017

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2. Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy

   Even in the presence of oxygen, malignant cells often highly depend on glycolysis for energy generation, a phenomenon known as the Warburg effect. One strategy targeting this metabolic phenotype is glucose res...

   Authors: Gabriele D Maurer, Daniel P Brucker, Oliver Bähr, Patrick N Harter, Elke Hattingen, Stefan Walenta, Wolfgang Mueller-Klieser, Joachim P Steinbach and Johannes Rieger

   Citation: BMC Cancer 2011 11:315

   Content type: Research article Published on: 26 July 2011

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