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Hemp (Cannabis sativa L.) Seed Oil: Analytical and Phytochemical Characterization of the Unsaponifiable Fraction

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Department of Pharmacology, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain
Laboratory of Cellular and Molecular Nutrition, Instituto de la Grasa, Spanish National Research Council (CSIC), 41012 Seville, Spain
*Telephone: +34659603457. E-mail: [email protected]
Cite this: J. Agric. Food Chem. 2014, 62, 5, 1105–1110
Publication Date (Web):January 15, 2014
https://doi.org/10.1021/jf404278q
Copyright © 2014 American Chemical Society

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    Abstract

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    Non-drug varieties of Cannabis sativa L., collectively namely as “hemp”, have been an interesting source of food, fiber, and medicine for thousands of years. The ever-increasing demand for vegetables oils has made it essential to characterize additional vegetable oil through innovative uses of its components. The lipid profile showed that linoleic (55%), α-linolenic (16%), and oleic (11%) were the most abundant fatty acids. A yield (1.84–1.92%) of unsaponifiable matter was obtained, and the most interesting compounds were β-sitosterol (1905.00 ± 59.27 mg/kg of oil), campesterol (505.69 ± 32.04 mg/kg of oil), phytol (167.59 ± 1.81 mg/kg of oil), cycloartenol (90.55 ± 3.44 mg/kg of oil), and γ-tocopherol (73.38 ± 2.86 mg/100 g of oil). This study is an interesting contribution for C. sativa L. consideration as a source of bioactive compounds contributing to novel research applications for hemp seed oil in the pharmaceutical, cosmetic food, and other non-food industries.

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    2. Suthawan Muangmeesri, Ning Li, Dimitrios Georgouvelas, Pierre Ouagne, Vincent Placet, Aji P. Mathew, Joseph S. M. Samec. Holistic Valorization of Hemp through Reductive Catalytic Fractionation. ACS Sustainable Chemistry & Engineering 2021, 9 (51) , 17207-17213. https://doi.org/10.1021/acssuschemeng.1c06607
    3. Julio Rea Martinez, Gordana Šelo, María Ángeles Fernández-Arche, Beatriz Bermudez, María Dolores García-Giménez. Dual Role of Phenyl Amides from Hempseed on BACE 1, PPARγ, and PGC-1α in N2a-APP Cells. Journal of Natural Products 2021, 84 (9) , 2447-2453. https://doi.org/10.1021/acs.jnatprod.1c00435
    4. Yuefang Zhou, Shanshan Wang, Jianbo Ji, Hongxiang Lou, Peihong Fan. Hemp (Cannabis sativa L.) Seed Phenylpropionamides Composition and Effects on Memory Dysfunction and Biomarkers of Neuroinflammation Induced by Lipopolysaccharide in Mice. ACS Omega 2018, 3 (11) , 15988-15995. https://doi.org/10.1021/acsomega.8b02250
    5. Guo-Yuan Zhu, Ji Yang, Xiao-Jun Yao, Xing Yang, Jing Fu, Xin Liu, Li-Ping Bai, Liang Liu, and Zhi-Hong Jiang . (±)-Sativamides A and B, Two Pairs of Racemic Nor-Lignanamide Enantiomers from the Fruits of Cannabis sativa. The Journal of Organic Chemistry 2018, 83 (4) , 2376-2381. https://doi.org/10.1021/acs.joc.7b02765
    6. Xiaoli Yan, Jiajing Tang, Carolina dos Santos Passos, Alessandra Nurisso, Claudia Avello Simões-Pires, Mei Ji, Hongxiang Lou, and Peihong Fan . Characterization of Lignanamides from Hemp (Cannabis sativa L.) Seed and Their Antioxidant and Acetylcholinesterase Inhibitory Activities. Journal of Agricultural and Food Chemistry 2015, 63 (49) , 10611-10619. https://doi.org/10.1021/acs.jafc.5b05282
    7. Milica Pojić, Aleksandra Mišan, Marijana Sakač, Tamara Dapčević Hadnađev, Bojana Šarić, Ivan Milovanović, and Miroslav Hadnađev . Characterization of Byproducts Originating from Hemp Oil Processing. Journal of Agricultural and Food Chemistry 2014, 62 (51) , 12436-12442. https://doi.org/10.1021/jf5044426
    8. Versha Kajal, Sanjit Boora, Sapna Wadhwa, Kumari Soniya, Suman Yadav, Sulochana Kaushik, Samander Kaushik. In silico approaches for study the therapeutic potential of Cannabis sativa (Bhang) against HIV. Advances in Traditional Medicine 2024, 24 (1) , 285-303. https://doi.org/10.1007/s13596-023-00697-z
    9. D. Lanzoni, E. Skrivanova, L. Pinotti, R. Rebucci, A. Baldi, C. Giromini. Review: Nutritional aspects of hemp-based products and their effects on health and performance of monogastric animals. animal 2024, 18 (2) , 101058. https://doi.org/10.1016/j.animal.2023.101058
    10. Christian Koeder, Federico J. A. Perez-Cueto. Vegan nutrition: a preliminary guide for health professionals. Critical Reviews in Food Science and Nutrition 2024, 64 (3) , 670-707. https://doi.org/10.1080/10408398.2022.2107997
    11. Suthinee Sangkanu, Thanet Pitakbut, Sathianpong Phoopha, Jiraporn Khanansuk, Kasemsiri Chandarajoti, Sukanya Dej-adisai. A Comparative Study of Chemical Profiling and Bioactivities between Thai and Foreign Hemp Seed Species (Cannabis sativa L.) Plus an In-Silico Investigation. Foods 2024, 13 (1) , 55. https://doi.org/10.3390/foods13010055
    12. Azam Jan Afridi, Amina Zuberi, Ali Muhammad Yousafzai, Muhammad Kamran. Therapeutic Role of Hemp (Cannabis sativa) Against Copper-Induced Toxicity in Labeo rohita and Cirrhinus mrigala. Biological Trace Element Research 2024, 202 (1) , 307-318. https://doi.org/10.1007/s12011-023-03650-y
    13. A. Kabutey, Č. Mizera, D. Herák. Evaluation of percentage oil yield, energy requirement and mechanical properties of selected bulk oilseeds under compression loading. Journal of Food Engineering 2024, 360 , 111719. https://doi.org/10.1016/j.jfoodeng.2023.111719
    14. Michaela Bartončíková, Barbora Lapčíková, Lubomír Lapčík, Tomáš Valenta. Hemp-Derived CBD Used in Food and Food Supplements. Molecules 2023, 28 (24) , 8047. https://doi.org/10.3390/molecules28248047
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    16. Nima Mohammadi, Nikoo Ostovar. Chemical composition, fatty acid composition, and volatile compounds of a traditional Kurdish fermented cereal food: Tarkhineh. Food Chemistry Advances 2023, 2 , 100187. https://doi.org/10.1016/j.focha.2023.100187
    17. Abraham Kabutey, David Herák, Čestmír Mizera. Assessment of Quality and Efficiency of Cold-Pressed Oil from Selected Oilseeds. Foods 2023, 12 (19) , 3636. https://doi.org/10.3390/foods12193636
    18. Agata Sumara, Anna Stachniuk, Magdalena Montowska, Klaudia Kotecka-Majchrzak, Ewelina Grywalska, Przemysław Mitura, Lara Saftić Martinović, Sandra Kraljević Pavelić, Emilia Fornal. Comprehensive Review of Seven Plant Seed Oils: Chemical Composition, Nutritional Properties, and Biomedical Functions. Food Reviews International 2023, 39 (8) , 5402-5422. https://doi.org/10.1080/87559129.2022.2067560
    19. Gianluca Rizzo, Maximilian Andreas Storz, Gioacchino Calapai. The Role of Hemp (Cannabis sativa L.) as a Functional Food in Vegetarian Nutrition. Foods 2023, 12 (18) , 3505. https://doi.org/10.3390/foods12183505
    20. Hashiya S. Muhammad, Reuben Agada, Ikoni J. Ogaji, Ndidi C. Ngwuluka. Physicochemical characterization and fatty acids composition of four indigenous plant oils. Scientific African 2023, 20 , e01669. https://doi.org/10.1016/j.sciaf.2023.e01669
    21. Jan-Hendrik Duminy, Neill Goosen, Eugéne van Rensburg, William Arries, Lucky Mokwena, Lindani Kotobe, Robert Pott. Application of different chromatographic techniques to characterise wax by-products generated during cannabinoid extraction. Biomass Conversion and Biorefinery 2023, 28 https://doi.org/10.1007/s13399-023-04448-7
    22. Xueping Han, Jinzheng Wang, Guiping Wang, Fang Dong, Peixian Nie, Xiaomin Xue. Transcriptome and metabolome analysis of flavonol synthesis in apricot fruits. Frontiers in Plant Science 2023, 14 https://doi.org/10.3389/fpls.2023.1187551
    23. Vincenzo Lo Turco, Federica Litrenta, Vincenzo Nava, Ambrogina Albergamo, Rossana Rando, Giovanni Bartolomeo, Angela Giorgia Potortì, Giuseppa Di Bella. Effect of Filtration Process on Oxidative Stability and Minor Compounds of the Cold-Pressed Hempseed Oil during Storage. Antioxidants 2023, 12 (6) , 1231. https://doi.org/10.3390/antiox12061231
    24. Matilde Tura, Mara Mandrioli, Enrico Valli, Tullia Gallina Toschi. Quality indexes and composition of 13 commercial hemp seed oils. Journal of Food Composition and Analysis 2023, 117 , 105112. https://doi.org/10.1016/j.jfca.2022.105112
    25. Emanuela Trovato, Katia Arena, Roberta La Tella, Francesca Rigano, Roberto Laganà Vinci, Paola Dugo, Luigi Mondello, Paolo Guarnaccia. Hemp seed-based food products as functional foods: A comprehensive characterization of secondary metabolites using liquid and gas chromatography methods. Journal of Food Composition and Analysis 2023, 117 , 105151. https://doi.org/10.1016/j.jfca.2023.105151
    26. Nayara Araujo dos Santos, Wanderson Romão. Cannabis – A state of the art about the millenary plant: Part I. Forensic Chemistry 2023, 32 , 100470. https://doi.org/10.1016/j.forc.2023.100470
    27. Muhammad Yasir Naeem, Filomena Corbo, Pasquale Crupi, Maria Lisa Clodoveo. Hemp: An Alternative Source for Various Industries and an Emerging Tool for Functional Food and Pharmaceutical Sectors. Processes 2023, 11 (3) , 718. https://doi.org/10.3390/pr11030718
    28. Andrea Cerrato, Sara Elsa Aita, Giuseppe Cannazza, Anna Laura Capriotti, Chiara Cavaliere, Cinzia Citti, Chiara Dal Bosco, Alessandra Gentili, Carmela Maria Montone, Roberta Paris, Aldo Laganà. Evaluation of the carotenoid and fat-soluble vitamin profile of industrial hemp inflorescence by liquid chromatography coupled to mass spectrometry and photodiode-array detection. Journal of Chromatography A 2023, 1692 , 463838. https://doi.org/10.1016/j.chroma.2023.463838
    29. Laura Serventi, Giancarlo Angeles Flores, Gaia Cusumano, Davide Barbaro, Bruno Tirillini, Roberto Venanzoni, Paola Angelini, Alessandra Acquaviva, Simonetta Cristina Di Simone, Giustino Orlando, Gokhan Zengin, Luigi Menghini, Claudio Ferrante. Comparative Investigation of Antimicrobial and Antioxidant Effects of the Extracts from the Inflorescences and Leaves of the Cannabis sativa L. cv. strawberry. Antioxidants 2023, 12 (2) , 219. https://doi.org/10.3390/antiox12020219
    30. Salvatore Ciano, Lucia Maddaloni, Mattia Rapa, Anna Maria Tarola. Organic hempseed oil from the retail market: chemical profiling and multivariate analysis for label information assessment. British Food Journal 2023, 125 (2) , 415-432. https://doi.org/10.1108/BFJ-08-2021-0924
    31. Lidia Montero, Diego Ballesteros-Vivas, Andrés Fernando Gonzalez-Barrios, Andrea del Pilar Sánchez-Camargo. Hemp seeds: Nutritional value, associated bioactivities and the potential food applications in the Colombian context. Frontiers in Nutrition 2023, 9 https://doi.org/10.3389/fnut.2022.1039180
    32. Roberto Mancinelli, Ambra Altimari, Patrizia Papetti, Emanuele Radicetti. The customer’s preference in light cannabis: an Italian perspective. 2023, 339-363. https://doi.org/10.1016/B978-0-323-89867-6.00004-4
    33. Lorenzo Nissen, Flavia Casciano, Elena Babini, Andrea Gianotti. Hemp seed products and by products: a mine of bioactive compounds to improve functionality of fermented foods. 2023, 393-406. https://doi.org/10.1016/B978-0-323-89867-6.00009-3
    34. Zinar Pinar Gumus, Zeliha Ustun Argon, Veysel Umut Celenk, Hasan Ertas. Bioactive Phytochemicals from Hemp (Cannabis sativa) Seed Oil Processing By-products. 2023, 669-684. https://doi.org/10.1007/978-3-030-91381-6_31
    35. Amaia Iriondo-DeHond, José Ignacio Alonso-Esteban, Paula Gallego-Barceló, Patricia García, Raquel Abalo, Maria Dolores del Castillo. Nutrition Security of Hemp for Human Consumption. 2023https://doi.org/10.1016/B978-0-12-823960-5.00048-2
    36. Salima Haddou, El Hassania Loukili, Asmae Hbika, Abdelkrim Chahine, Belkheir Hammouti. Phytochemical study using HPLC-UV/GC–MS of different of Cannabis sativa L seeds extracts from Morocco. Materials Today: Proceedings 2023, 72 , 3896-3903. https://doi.org/10.1016/j.matpr.2022.10.215
    37. Peng‐Wei Xu, Xiao‐Fan Yuan, Bing Zhao. Bioactive polyphenols separated from hemp seed shells ameliorate H 2 O 2 ‐induced oxidative stress injury in human umbilical vein endothelial cells. Journal of Food Science 2023, 88 (1) , 537-551. https://doi.org/10.1111/1750-3841.16424
    38. Inga Grigaliūnaitė, Maria-Victoria Ruiz-Méndez. Cleaner lipid processing: Supercritical carbon dioxide (Sc-CO2) and short path distillation. 2023, 255-300. https://doi.org/10.1016/bs.afnr.2022.12.001
    39. Atefeh Amiri-Rigi, Sreejarani Kesavan Pillai, Mohammad Naushad Emmambux. Development of hemp seed oil nanoemulsions loaded with ascorbyl palmitate: Effect of operational parameters, emulsifiers, and wall materials. Food Chemistry 2023, 400 , 134052. https://doi.org/10.1016/j.foodchem.2022.134052
    40. José Ignacio Alonso-Esteban, María José González-Fernández, Dmitri Fabrikov, María de Cortes Sánchez-Mata, Esperanza Torija-Isasa, José Luis Guil-Guerrero. Fatty acids and minor functional compounds of hemp (Cannabis sativa L.) seeds and other Cannabaceae species. Journal of Food Composition and Analysis 2023, 115 , 104962. https://doi.org/10.1016/j.jfca.2022.104962
    41. Muhammad Faizan Afzal, Waseem Khalid, Muhammad Armghan Khalid, Muhammad Zubair, Sidra Akram, Safura Kauser, Sana Noreen, Athar Jamal, Muhammad Kamran Khan, Ammar Al-Farga. Recent industrials extraction of plants seeds oil used in the development of functional food products: A Review. International Journal of Food Properties 2022, 25 (1) , 2530-2550. https://doi.org/10.1080/10942912.2022.2144882
    42. Dorota Chelminiak-Dudkiewicz, Aleksander Smolarkiewicz-Wyczachowski, Kinga Mylkie, Magdalena Wujak, Dariusz T. Mlynarczyk, Pawel Nowak, Szymon Bocian, Tomasz Goslinski, Marta Ziegler-Borowska. Chitosan-based films with cannabis oil as a base material for wound dressing application. Scientific Reports 2022, 12 (1) https://doi.org/10.1038/s41598-022-23506-0
    43. Monika Kalinowska, Anna Płońska, Magdalena Trusiak, Ewelina Gołębiewska, Anna Gorlewska-Pietluszenko. Comparing the extraction methods, chemical composition, phenolic contents and antioxidant activity of edible oils from Cannabis sativa and Silybum marianu seeds. Scientific Reports 2022, 12 (1) https://doi.org/10.1038/s41598-022-25030-7
    44. Marlize Krüger, Tertia van Eeden, Daniso Beswa. Cannabis sativa Cannabinoids as Functional Ingredients in Snack Foods—Historical and Developmental Aspects. Plants 2022, 11 (23) , 3330. https://doi.org/10.3390/plants11233330
    45. Hebah M.S. AL Ubeed, Charles S. Brennan, Ellen Schanknecht, Muhammad A. Alsherbiny, Md Saifullah, Kien Nguyen, Quan V. Vuong. Potential applications of hemp ( Cannabis sativa L.) extracts and their phytochemicals as functional ingredients in food and medicinal supplements: a narrative review. International Journal of Food Science & Technology 2022, 57 (12) , 7542-7555. https://doi.org/10.1111/ijfs.16116
    46. John Staton Laws, Scott D. Smid. Evaluating Cannabis sativa L.’s neuroprotection potential: From bench to bedside. Phytomedicine 2022, 107 , 154485. https://doi.org/10.1016/j.phymed.2022.154485
    47. Mattia Spano, Giacomo Di Matteo, Cinzia Ingallina, Anatoly Petrovich Sobolev, Anna Maria Giusti, Giuliana Vinci, Silvia Cammarone, Carola Tortora, Lara Lamelza, Sabrina Antonia Prencipe, Laura Gobbi, Bruno Botta, Federico Marini, Enio Campiglia, Luisa Mannina. Industrial Hemp (Cannabis sativa L.) Inflorescences as Novel Food: The Effect of Different Agronomical Practices on Chemical Profile. Foods 2022, 11 (22) , 3658. https://doi.org/10.3390/foods11223658
    48. B. Dave Oomah. Hempseed. 2022, 269-356. https://doi.org/10.1002/9781119804055.ch9
    49. Агата Анатольевна Гончарова, Валентин Игоревич Ущаповский, Ирина Эдуардовна Миневич. Влияние продуктов переработки семян конопли на потребительские свойства мучных кондитерских изделий. Хранение и переработка сельхозсырья 2022, (3) https://doi.org/10.36107/spfp.2022.291
    50. Serena Fiorito, Francesco Epifano, Lucia Palumbo, Chiara Collevecchio, Salvatore Genovese. A subcritical butane-based extraction of non-psychoactive cannabinoids from hemp inflorescences. Industrial Crops and Products 2022, 183 , 114955. https://doi.org/10.1016/j.indcrop.2022.114955
    51. Antonella Di Sotto, Marco Gullì, Alessandra Acquaviva, Massimo Tacchini, Simonetta Cristina Di Simone, Annalisa Chiavaroli, Lucia Recinella, Sheila Leone, Luigi Brunetti, Giustino Orlando, Giancarlo Angeles Flores, Roberto Venanzoni, Paola Angelini, Luigi Menghini, Claudio Ferrante. Phytochemical and pharmacological profiles of the essential oil from the inflorescences of the Cannabis sativa L.. Industrial Crops and Products 2022, 183 , 114980. https://doi.org/10.1016/j.indcrop.2022.114980
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    54. Cristina Occhiuto, Gianluigi Aliberto, Mariarosaria Ingegneri, Domenico Trombetta, Clara Circosta, Antonella Smeriglio. Comparative Evaluation of the Nutrients, Phytochemicals, and Antioxidant Activity of Two Hempseed Oils and Their Byproducts after Cold Pressing. Molecules 2022, 27 (11) , 3431. https://doi.org/10.3390/molecules27113431
    55. Zeyuan Wang, Lehao Wu, Dongmei Fu, Yan Zhang, Chunzhi Zhang. Hemp Seed Fermented by Aspergillus oryzae Attenuates Lipopolysaccharide-Stimulated Inflammatory Responses in N9 Microglial Cells. Foods 2022, 11 (12) , 1689. https://doi.org/10.3390/foods11121689
    56. Abhiroop Mookerjee, Venu Babu Borugadda, Ajay K. Dalai, Venkatesh Meda. Valorization of hemp hearts oils by advanced extraction techniques and their comparative physicochemical characterization. Applied Food Research 2022, 2 (1) , 100051. https://doi.org/10.1016/j.afres.2022.100051
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    59. Na Li, Tong Wang, Xinrun Yang, Jiayao Qu, Ning Wang, Liqi Wang, Dianyu Yu, Cuiping Han. Effect of high-intensity ultrasonic treatment on the emulsion of hemp seed oil stabilized with hemp seed protein. Ultrasonics Sonochemistry 2022, 86 , 106021. https://doi.org/10.1016/j.ultsonch.2022.106021
    60. Rongjing Zhu, Qing Yuan, Guanghui Du, Gang Deng, Yang Yang, Rehman Muzammal, Feihu Liu. Morpho-physiological traits, antioxidant capacity and nutrient accumulation in hemp ( Cannabis sativa L.) under varying levels of nitrogen nutrition. Journal of Plant Nutrition 2022, 45 (6) , 854-865. https://doi.org/10.1080/01904167.2021.1994596
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    62. Anna Olejnik, Aleksandra Galarda, Joanna Goscianska. The Beneficial Effect of Cannabis sativa Seed Oil on the Epidermis. Current Cosmetic Science 2022, 1 (1) https://doi.org/10.2174/2666779701666210408111006
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    64. Francesca Blasi, Carmela Tringaniello, Giuseppa Verducci, Lina Cossignani. Bioactive minor components of Italian and Extra-European hemp seed oils. LWT 2022, 158 , 113167. https://doi.org/10.1016/j.lwt.2022.113167
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    66. Carmen Socaciu, Francisc Dulf, Sonia Socaci, Floricuta Ranga, Andrea Bunea, Florinela Fetea, Adela Pintea. Phytochemical Profile of Eight Categories of Functional Edible Oils: A Metabolomic Approach Based on Chromatography Coupled with Mass Spectrometry. Applied Sciences 2022, 12 (4) , 1933. https://doi.org/10.3390/app12041933
    67. Mohammed Jawad, Suad Ibrahim, Mayur Kumar, Charlie Burgert, Wen-Wu Li, Alan Richardson. Identification of foods that affect the anti‑cancer activity of pitavastatin in cells. Oncology Letters 2022, 23 (3) https://doi.org/10.3892/ol.2022.13193
    68. Sarah Schlag, Yining Huang, Walter Vetter. GC/EI-MS method for the determination of phytosterols in vegetable oils. Analytical and Bioanalytical Chemistry 2022, 414 (2) , 1061-1071. https://doi.org/10.1007/s00216-021-03730-9
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    70. Biljana B. Rabrenović, Vesna B. Vujasinović. Industrial hempseed oil and lipids: Processing and properties. 2022, 95-124. https://doi.org/10.1016/B978-0-323-90910-5.00003-8
    71. Viviana di Giacomo, Claudio Ferrante, Luigi Menghini, Giustino Orlando. Nutraceutical potential of industrial hemp. 2022, 173-190. https://doi.org/10.1016/B978-0-323-90910-5.00006-3
    72. Jikai Zhao, Weiqun Wang, Yonghui Li, Xiuzhi Sun, Donghai Wang. Nutritional and chemical composition of industrial hemp seeds. 2022, 73-93. https://doi.org/10.1016/B978-0-323-90910-5.00013-0
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    74. Sanusi Shamsudeen Nassarawa, S. Dutta Gupta, Munir Abba Dandago. Hemp Usage in Cosmeceutical and Personal Care Industry. 2022, 145-155. https://doi.org/10.1007/978-3-031-05144-9_7
    75. Sanusi Shamsudeen Nassarawa, Munir Abba Dandago. Hemp Usage as Regular Food and in Nutraceutical Industry. 2022, 135-144. https://doi.org/10.1007/978-3-031-05144-9_6
    76. Z. Pinar Gumus, Zeliha Ustun Argon, Veysel Umut Celenk, Hasan Ertas. Bioactive Phytochemicals from Hemp (Cannabis sativa) Seed Oil Processing By-products. 2022, 1-16. https://doi.org/10.1007/978-3-030-63961-7_31-1
    77. Shivika Datta, Praveen C. Ramamurthy, Uttpal Anand, Simranjeet Singh, Amritpal Singh, Daljeet Singh Dhanjal, Vaishali Dhaka, Sanjay Kumar, Dhriti Kapoor, Samapika Nandy, Manoj Kumar, Eapen P. Koshy, Abhijit Dey, Jarosław Proćków, Joginder Singh. Wonder or evil?: Multifaceted health hazards and health benefits of Cannabis sativa and its phytochemicals. Saudi Journal of Biological Sciences 2021, 28 (12) , 7290-7313. https://doi.org/10.1016/j.sjbs.2021.08.036
    78. Isaac Karimi, Namdar Yousofvand, Baydaa Abed Hussein. In vitro cholinesterase inhibitory action of Cannabis sativa L. Cannabaceae and in silico study of its selected phytocompounds. In Silico Pharmacology 2021, 9 (1) https://doi.org/10.1007/s40203-021-00075-0
    79. Sandra Weck, Verena Peterseil, Helmut K. Mayer, Rupert Hochegger. Development and validation of a real-time PCR assay to detect Cannabis sativa in food. Scientific Reports 2021, 11 (1) https://doi.org/10.1038/s41598-021-83908-4
    80. Kacper Przykaza, Hanna Nikolaichuk, Anna Kozub, Jolanta Tomaszewska-Gras, Željka Peršurić, Sandra Kraljević Pavelić, Emilia Fornal. Newly marketed seed oils. What we can learn from the current status of authentication of edible oils. Food Control 2021, 130 , 108349. https://doi.org/10.1016/j.foodcont.2021.108349
    81. Christelle Lopez, Bruno Novales, Hanitra Rabesona, Magalie Weber, Thierry Chardot, Marc Anton. Deciphering the properties of hemp seed oil bodies for food applications: Lipid composition, microstructure, surface properties and physical stability. Food Research International 2021, 150 , 110759. https://doi.org/10.1016/j.foodres.2021.110759
    82. Giovanna Calixto Garcia Carlini, Gabriela Grassmann Roschel, Roseli Aparecida Ferrari, Severino Mathias Alencar, Helton Cherubim Ota, Tayse Ferreira Ferreira da Silveira, Inar Alves Castro. Chemical characterization of Echium plantagineum seed oil obtained by three methods of extraction. Journal of Food Science 2021, 86 (12) , 5307-5317. https://doi.org/10.1111/1750-3841.15972
    83. Joanna Kanabus, Marcin Bryła, Marek Roszko, Marta Modrzewska, Adam Pierzgalski. Cannabinoids—Characteristics and Potential for Use in Food Production. Molecules 2021, 26 (21) , 6723. https://doi.org/10.3390/molecules26216723
    84. Yassine Taaifi, Abdessamad Benmoumen, Kamal Belhaj, Smail Aazza, Malika Abid, Embarek Azeroual, Ahmed Elamrani, Farid Mansouri, Hana Serghini Caid. Seed composition of non‐industrial hemp ( Cannabis sativa L.) varieties from four regions in northern Morocco. International Journal of Food Science & Technology 2021, 56 (11) , 5931-5947. https://doi.org/10.1111/ijfs.15136
    85. Muzammal Rehman, Shah Fahad, Guanghui Du, Xia Cheng, Yang Yang, Kailei Tang, Lijun Liu, Fei-Hu Liu, Gang Deng. Evaluation of hemp (Cannabis sativa L.) as an industrial crop: a review. Environmental Science and Pollution Research 2021, 28 (38) , 52832-52843. https://doi.org/10.1007/s11356-021-16264-5
    86. Shrinivas Lamani, Konerira Aiyappa Anu-Appaiah, Hosakatte Niranjana Murthy, Yaser Hassan Dewir, Hail Z. Rihan. Fatty Acid Profile, Tocopherol Content of Seed Oil, and Nutritional Analysis of Seed Cake of Wood Apple (Limonia acidissima L.), an Underutilized Fruit-Yielding Tree Species. Horticulturae 2021, 7 (9) , 275. https://doi.org/10.3390/horticulturae7090275
    87. Carmen Botella-Martínez, José Ángel Pérez-Álvarez, Estrella Sayas-Barberá, Juana Fernández-López, Manuel Viuda-Martos. Assessment of Chemical, Physicochemical, and Lipid Stability Properties of Gelled Emulsions Elaborated with Different Oils Chia (Salvia hispanica L.) or Hemp (Cannabis sativa L.) and Pseudocereals. Foods 2021, 10 (7) , 1463. https://doi.org/10.3390/foods10071463
    88. Halime Özdemir, Emre Bakkalbaşı, Issa Javidipour. Effect of seed roasting on oxidative stability and antioxidant content of hemp seed oil. Journal of Food Science and Technology 2021, 58 (7) , 2606-2616. https://doi.org/10.1007/s13197-020-04767-x
    89. Diana Carolina Riveros Santoya, Eliana Andrea Portilla Mogollón. Regulación actual del cannabis visto desde los beneficios terapéuticos de los cannabinoides. Revista La Propiedad Inmaterial 2021, (31) , 195-208. https://doi.org/10.18601/16571959.n31.07
    90. Giuseppe Sorrentino. Introduction to emerging industrial applications of cannabis (Cannabis sativa L.). Rendiconti Lincei. Scienze Fisiche e Naturali 2021, 32 (2) , 233-243. https://doi.org/10.1007/s12210-021-00979-1
    91. Slavko Komarnytsky, Thirumurugan Rathinasabapathy, Charles Wagner, Brandon Metzger, Carolina Carlisle, Chinmayee Panda, Sara Le Brun-Blashka, John P. Troup, Saradhadevi Varadharaj. Endocannabinoid System and Its Regulation by Polyunsaturated Fatty Acids and Full Spectrum Hemp Oils. International Journal of Molecular Sciences 2021, 22 (11) , 5479. https://doi.org/10.3390/ijms22115479
    92. Ines Barthlott, Andreas Scharinger, Patricia Golombek, Thomas Kuballa, Dirk Lachenmeier. A Quantitative 1H NMR Method for Screening Cannabinoids in CBD Oils. Toxics 2021, 9 (6) , 136. https://doi.org/10.3390/toxics9060136
    93. Song-Yi Gu, Hee-Chang Shin, Dae-Jung Kim, Sang Un Park, Yong-Kyoung Kim. The content and health risk assessment of micro and toxic elements in cereals (oat and quinoa), legumes (lentil and chick pea), and seeds (chia, hemp, and flax). Journal of Food Composition and Analysis 2021, 99 , 103881. https://doi.org/10.1016/j.jfca.2021.103881
    94. Cesarettin Alasalvar, Sui Kiat Chang, Bradley Bolling, Won Young Oh, Fereidoon Shahidi. Specialty seeds: Nutrients, bioactives, bioavailability, and health benefits: A comprehensive review. Comprehensive Reviews in Food Science and Food Safety 2021, 20 (3) , 2382-2427. https://doi.org/10.1111/1541-4337.12730
    95. Davide Calzolari, Gabriele Rocchetti, Luigi Lucini, Stefano Amaducci. The variety, terroir, and harvest types affect the yield and the phenolic and sterolic profiles of hemp seed oil. Food Research International 2021, 142 , 110212. https://doi.org/10.1016/j.foodres.2021.110212
    96. Giustino Orlando, Sabrina Adorisio, Domenico Delfino, Annalisa Chiavaroli, Luigi Brunetti, Lucia Recinella, Sheila Leone, Marianna D’Antonio, Gokhan Zengin, Alessandra Acquaviva, Mirko Antico, Paola Angelini, Giancarlo Angeles Flores, Roberto Venanzoni, Massimo Tacchini, Simonetta Cristina Di Simone, Luigi Menghini, Claudio Ferrante. Comparative Investigation of Composition, Antifungal, and Anti-Inflammatory Effects of the Essential Oil from Three Industrial Hemp Varieties from Italian Cultivation. Antibiotics 2021, 10 (3) , 334. https://doi.org/10.3390/antibiotics10030334
    97. Youjie Xu, Jikai Zhao, Ruijia Hu, Weiqun Wang, Jason Griffin, Yonghui Li, Xiuzhi Susan Sun, Donghai Wang. Effect of genotype on the physicochemical, nutritional, and antioxidant properties of hempseed. Journal of Agriculture and Food Research 2021, 3 , 100119. https://doi.org/10.1016/j.jafr.2021.100119
    98. Julio Rea, M. D. García-Giménez, Marti Santiago, Rocío De la Puerta, M. A. Fernández-Arche. Hydroxycinnamic acid derivatives isolated from hempseed and their effects on central nervous system enzymes. International Journal of Food Sciences and Nutrition 2021, 72 (2) , 184-194. https://doi.org/10.1080/09637486.2020.1793305
    99. Youjie Xu, Jun Li, Jikai Zhao, Weiqun Wang, Jason Griffin, Yonghui Li, Scott Bean, Mike Tilley, Donghai Wang. Hempseed as a nutritious and healthy human food or animal feed source: a review. International Journal of Food Science & Technology 2021, 56 (2) , 530-543. https://doi.org/10.1111/ijfs.14755
    100. Monika Michalak, Monika Pierzak, Beata Kręcisz, Edyta Suliga. Bioactive Compounds for Skin Health: A Review. Nutrients 2021, 13 (1) , 203. https://doi.org/10.3390/nu13010203
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