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Enhanced Production of Resveratrol, Piceatannol, Arachidin-1, and Arachidin-3 in Hairy Root Cultures of Peanut Co-treated with Methyl Jasmonate and Cyclodextrin

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† # †Arkansas Biosciences Institute, ‡Molecular Biosciences Graduate Program, and #Department of Biological Sciences, Arkansas State University, State University, Arkansas 72467, United States
*(F.M.-B.) Mail: Arkansas Biosciences Institute, Arkansas State University, P.O. Box 639, State University, AR 72467, USA. Phone: (870) 680-4319. Fax: (870) 680-4348. E-mail: [email protected]
Cite this: J. Agric. Food Chem. 2015, 63, 15, 3942–3950
Publication Date (Web):April 2, 2015
https://doi.org/10.1021/jf5050266
Copyright © 2015 American Chemical Society
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    Abstract

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    Peanut (Arachis hypogaea) produces stilbenoids upon exposure to abiotic and biotic stresses. Among these compounds, the prenylated stilbenoids arachidin-1 and arachidin-3 have shown diverse biological activities with potential applications in human health. These compounds exhibit higher or novel biological activities in vitro when compared to their nonprenylated analogues piceatannol and resveratrol, respectively. However, assessment of these bioactivities in vivo has been challenging because of their limited availability. In this study, hairy root cultures of peanut were induced to produce stilbenoids upon treatment with elicitors. Co-treatment with 100 μM methyl jasmonate (MeJA) and 9 g/L methyl-β-cyclodextrin (CD) led to sustained high levels of resveratrol, piceatannol, arachidin-1, and arachidin-3 in the culture medium when compared to other elicitor treatments. The average yields of arachidin-1 and arachidin-3 were 56 and 148 mg/L, respectively, after co-treatment with MeJA and CD. Furthermore, MeJA and CD had a synergistic effect on resveratrol synthase gene expression, which could explain the higher yield of resveratrol when compared to treatment with either MeJA or CD alone. Peanut hairy root cultures were shown to be a controlled and sustainable axenic system for the production of the diverse types of biologically active stilbenoids.

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    11. Muzaffer Barut, Asiye Sena Cavdar, Leyla Sezen Tansi. Medicinal Legumes in Turkey: A Gift of Nature for Bios. 2023, 481-506. https://doi.org/10.1007/978-3-031-33957-8_21
    12. Barbara De Filippis, Marialuigia Fantacuzzi. Recent Development of Hybrids and Derivatives of Resveratrol in Neurodegenerative Diseases. 2022, 27-72. https://doi.org/10.2174/9789815079098122010005
    13. Chaiwat Aneklaphakij, Phatthilakorn Chamnanpuen, Somnuk Bunsupa, Veena Satitpatipan. Recent Green Technologies in Natural Stilbenoids Production and Extraction: The Next Chapter in the Cosmetic Industry. Cosmetics 2022, 9 (5) , 91. https://doi.org/10.3390/cosmetics9050091
    14. Amit Sharma, Gaurav Gajurel, Izzeldin Ahmed, Krystian Roedel, Fabricio Medina-Bolivar. Induction of the Prenylated Stilbenoids Arachidin-1 and Arachidin-3 and Their Semi-Preparative Separation and Purification from Hairy Root Cultures of Peanut (Arachis hypogaea L.). Molecules 2022, 27 (18) , 6118. https://doi.org/10.3390/molecules27186118
    15. Janusz Malarz, Klaudia Michalska, Yulia V. Yudina, Anna Stojakowska. Hairy Root Cultures as a Source of Polyphenolic Antioxidants: Flavonoids, Stilbenoids and Hydrolyzable Tannins. Plants 2022, 11 (15) , 1950. https://doi.org/10.3390/plants11151950
    16. Romina Bodoira, M. Cecilia Cittadini, Alexis Velez, Yanina Rossi, Mariana Montenegro, Marcela Martínez, Damián Maestri. An overview on extraction, composition, bioactivity and food applications of peanut phenolics. Food Chemistry 2022, 381 , 132250. https://doi.org/10.1016/j.foodchem.2022.132250
    17. Marialuigia Fantacuzzi, Rosa Amoroso, Simone Carradori, Barbara De Filippis. Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy. European Journal of Medicinal Chemistry 2022, 233 , 114242. https://doi.org/10.1016/j.ejmech.2022.114242
    18. Gaurav Gajurel, Luis Nopo-Olazabal, Emily Hendrix, Fabricio Medina-Bolivar. Production and Secretion of Isowighteone in Hairy Root Cultures of Pigeon Pea (Cajanus cajan) Co-Treated with Multiple Elicitors. Plants 2022, 11 (6) , 834. https://doi.org/10.3390/plants11060834
    19. Sepideh Mohammadhosseinpour, Linh-Chi Ho, Lingling Fang, Jianfeng Xu, Fabricio Medina-Bolivar. Arachidin-1, a Prenylated Stilbenoid from Peanut, Induces Apoptosis in Triple-Negative Breast Cancer Cells. International Journal of Molecular Sciences 2022, 23 (3) , 1139. https://doi.org/10.3390/ijms23031139
    20. R. Aswati Nair, K. Harsha, K. Harshitha, T. Shilpa, Padmesh Pillai. Secondary Metabolite Production from Roots/Rhizomes: Prospects and Challenges in Developing Differentiated Cultures Using the Plant’s Hidden Half. 2022, 447-475. https://doi.org/10.1007/978-981-19-5779-6_18
    21. Philippe Jeandet, Eduardo Sobarzo-Sánchez, Md. Sahab Uddin, Roque Bru, Christophe Clément, Cédric Jacquard, Seyed Fazel Nabavi, Maryam Khayatkashani, Gaber El-Saber Batiha, Haroon Khan, Iwona Morkunas, Franscesco Trotta, Adrian Matencio, Seyed Mohammad Nabavi. Resveratrol and cyclodextrins, an easy alliance: Applications in nanomedicine, green chemistry and biotechnology. Biotechnology Advances 2021, 53 , 107844. https://doi.org/10.1016/j.biotechadv.2021.107844
    22. A. Loni, S. Saadatmand, H. Lari Yazdi, A. Iranbakhsh. Effect of β-Cyclodextrin Nanoparticle on Biosynthesis of Ocimum basilicum L. Monoterpenes, Sesquiterpenes in a Concentration-Dependent Behavior. Russian Journal of Plant Physiology 2021, 68 (6) , 1087-1097. https://doi.org/10.1134/S102144372106011X
    23. Gaurav Gajurel, Rokib Hasan, Fabricio Medina-Bolivar. Antioxidant Assessment of Prenylated Stilbenoid-Rich Extracts from Elicited Hairy Root Cultures of Three Cultivars of Peanut (Arachis hypogaea). Molecules 2021, 26 (22) , 6778. https://doi.org/10.3390/molecules26226778
    24. Phadtraphorn Chayjarung, Wannakan Poonsap, Chanyanut Pankaew, Onrut Inmano, Anupan Kongbangkerd, Apinun Limmongkon. Using a combination of chitosan, methyl jasmonate, and cyclodextrin as an effective elicitation strategy for prenylated stilbene compound production in Arachis hypogaea L. hairy root culture and their impact on genomic DNA. Plant Cell, Tissue and Organ Culture (PCTOC) 2021, 147 (1) , 117-129. https://doi.org/10.1007/s11240-021-02112-4
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    26. Philippe Jeandet, Alessandro Vannozzi, Eduardo Sobarzo-Sánchez, Md. Sahab Uddin, Roque Bru, Ascension Martínez-Márquez, Christophe Clément, Sylvain Cordelier, Azadeh Manayi, Seyed Fazel Nabavi, Mahsa Rasekhian, Gaber El-Saber Batiha, Haroon Khan, Iwona Morkunas, Tarun Belwal, Jingjie Jiang, Mattheos Koffas, Seyed Mohammad Nabavi. Phytostilbenes as agrochemicals: biosynthesis, bioactivity, metabolic engineering and biotechnology. Natural Product Reports 2021, 38 (7) , 1282-1329. https://doi.org/10.1039/D0NP00030B
    27. Alessio Valletta, Lorenzo Maria Iozia, Francesca Leonelli. Impact of Environmental Factors on Stilbene Biosynthesis. Plants 2021, 10 (1) , 90. https://doi.org/10.3390/plants10010090
    28. Vijakhana Pilaisangsuree, Piyanuch Anuwan, Kanitha Supdensong, Pimpimon Lumpa, Anupan Kongbangkerd, Apinun Limmongkon. Enhancement of adaptive response in peanut hairy root by exogenous signalling molecules under cadmium stress. Journal of Plant Physiology 2020, 254 , 153278. https://doi.org/10.1016/j.jplph.2020.153278
    29. Lorena Almagro, María Ángeles Pedreño. Use of cyclodextrins to improve the production of plant bioactive compounds. Phytochemistry Reviews 2020, 19 (4) , 1061-1080. https://doi.org/10.1007/s11101-020-09704-6
    30. Noemi Gutierrez-Valdes, Suvi T. Häkkinen, Camille Lemasson, Marina Guillet, Kirsi-Marja Oksman-Caldentey, Anneli Ritala, Florian Cardon. Hairy Root Cultures—A Versatile Tool With Multiple Applications. Frontiers in Plant Science 2020, 11 https://doi.org/10.3389/fpls.2020.00033
    31. Lingling Fang, Tianhong Yang, Fabricio Medina-Bolivar. Production of Prenylated Stilbenoids in Hairy Root Cultures of Peanut (Arachis hypogaea) and Its Wild Relatives A. ipaensis and A. duranensis via an Optimized Elicitation Procedure. Molecules 2020, 25 (3) , 509. https://doi.org/10.3390/molecules25030509
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    33. Mihir Halder, Sayantika Sarkar, Sumita Jha. Elicitation: A biotechnological tool for enhanced production of secondary metabolites in hairy root cultures. Engineering in Life Sciences 2019, 19 (12) , 880-895. https://doi.org/10.1002/elsc.201900058
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    36. Thapakorn Somboon, Phadtraphorn Chayjarung, Vijakhana Pilaisangsuree, Parintorn Keawracha, Porntawan Tonglairoum, Anupan Kongbangkerd, Kanjana Wongkrajang, Apinun Limmongkon. Methyl jasmonate and cyclodextrin-mediated defense mechanism and protective effect in response to paraquat-induced stress in peanut hairy root. Phytochemistry 2019, 163 , 11-22. https://doi.org/10.1016/j.phytochem.2019.03.017
    37. Lan Wen, Weilin Jian, Junbing Shang, Daohang He. Synthesis and antifungal activities of novel thiophene‐based stilbene derivatives bearing an 1,3,4‐oxadiazole unit. Pest Management Science 2019, 75 (4) , 1123-1130. https://doi.org/10.1002/ps.5229
    38. Qingshou Yao, Zipeng Yu, Pu Liu, Hao Zheng, Yang Xu, Sixiang Sai, Yuyong Wu, Chengchao Zheng. High Efficient Expression and Purification of Human Epidermal Growth Factor in Arachis Hypogaea L.. International Journal of Molecular Sciences 2019, 20 (8) , 2045. https://doi.org/10.3390/ijms20082045
    39. Yan-Wei Tang, Cun-Jian Shi, Hua-Li Yang, Pei Cai, Qiao-Hong Liu, Xue-Lian Yang, Ling-Yi Kong, Xiao-Bing Wang. Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease. European Journal of Medicinal Chemistry 2019, 163 , 307-319. https://doi.org/10.1016/j.ejmech.2018.11.040
    40. Arockiam Sagina Rency, Subramani Pandian, Rakkammal Kasinathan, Lakkakula Satish, Mallappa Kumara Swamy, Manikandan Ramesh. Hairy Root Cultures as an Alternative Source for the Production of High-Value Secondary Metabolites. 2019, 237-264. https://doi.org/10.1007/978-981-13-7438-8_10
    41. MingYu Chu, Lorena Almagro, BaiHong Chen, Lorenzo Burgos, María Angeles Pedreño. Recent trends and comprehensive appraisal for the biotechnological production of trans-resveratrol and its derivatives. Phytochemistry Reviews 2018, 17 (3) , 491-508. https://doi.org/10.1007/s11101-017-9546-9
    42. Heriberto R. Vidal-Limon, Lorena Almagro, Elisabeth Moyano, Javier Palazon, Maria A. Pedreño, Rosa M. Cusido. Perfluorodecalins and Hexenol as Inducers of Secondary Metabolism in Taxus media and Vitis vinifera Cell Cultures. Frontiers in Plant Science 2018, 9 https://doi.org/10.3389/fpls.2018.00335
    43. Futoshi Taura, Miu Iijima, Fumiya Kurosaki. Daurichromenic acid and grifolic acid: Phytotoxic meroterpenoids that induce cell death in cell culture of their producer Rhododendron dauricum. Plant Signaling & Behavior 2018, 13 (1) , e1422463. https://doi.org/10.1080/15592324.2017.1422463
    44. Kulwinder Kaur, Pratap Kumar Pati. Stress-Induced Metabolite Production Utilizing Plant Hairy Roots. 2018, 123-145. https://doi.org/10.1007/978-981-13-2562-5_6
    45. Vijakhana Pilaisangsuree, Thapakorn Somboon, Porntawan Tonglairoum, Parintorn Keawracha, Thanakorn Wongsa, Anupan Kongbangkerd, Apinun Limmongkon. Enhancement of stilbene compounds and anti-inflammatory activity of methyl jasmonate and cyclodextrin elicited peanut hairy root culture. Plant Cell, Tissue and Organ Culture (PCTOC) 2018, 132 (1) , 165-179. https://doi.org/10.1007/s11240-017-1321-5
    46. Tianhong Yang, Lingling Fang, Sheri Sanders, Srinivas Jayanthi, Gayathri Rajan, Ram Podicheti, Suresh Kumar Thallapuranam, Keithanne Mockaitis, Fabricio Medina-Bolivar. Stilbenoid prenyltransferases define key steps in the diversification of peanut phytoalexins. Journal of Biological Chemistry 2018, 293 (1) , 28-46. https://doi.org/10.1074/jbc.RA117.000564
    47. Diego Hidalgo, Milen Georgiev, Andrey Marchev, Roque Bru-Martínez, Rosa M. Cusido, Purificación Corchete, Javier Palazon. Tailoring tobacco hairy root metabolism for the production of stilbenes. Scientific Reports 2017, 7 (1) https://doi.org/10.1038/s41598-017-18330-w
    48. Joshua R. Gershlak, Sarah Hernandez, Gianluca Fontana, Luke R. Perreault, Katrina J. Hansen, Sara A. Larson, Bernard Y.K. Binder, David M. Dolivo, Tianhong Yang, Tanja Dominko, Marsha W. Rolle, Pamela J. Weathers, Fabricio Medina-Bolivar, Carole L. Cramer, William L. Murphy, Glenn R. Gaudette. Crossing kingdoms: Using decellularized plants as perfusable tissue engineering scaffolds. Biomaterials 2017, 125 , 13-22. https://doi.org/10.1016/j.biomaterials.2017.02.011
    49. Ansgar Rühlmann, Dragutin Antovic, Thomas J. J. Müller, Vlada B. Urlacher. Regioselective Hydroxylation of Stilbenes by Engineered Cytochrome P450 from Thermobifida fusca YX. Advanced Synthesis & Catalysis 2017, 359 (6) , 984-994. https://doi.org/10.1002/adsc.201601168
    50. Tianhong Yang, Lingling Fang, Fabricio Medina-Bolivar. Production and Biosynthesis of Bioactive Stilbenoids in Hairy Root Cultures. 2017, 45-64. https://doi.org/10.1007/978-3-319-69769-7_3
    51. Leo-Paul Tisserant, Aziz Aziz, Nathalie Jullian, Philippe Jeandet, Christophe Clément, Eric Courot, Michèle Boitel-Conti. Enhanced Stilbene Production and Excretion in Vitis vinifera cv Pinot Noir Hairy Root Cultures. Molecules 2016, 21 (12) , 1703. https://doi.org/10.3390/molecules21121703
    52. Weilin Jian, Daohang He, Shaoyun Song. Synthesis, Biological Evaluation and Molecular Modeling Studies of New Oxadiazole-Stilbene Hybrids against Phytopathogenic Fungi. Scientific Reports 2016, 6 (1) https://doi.org/10.1038/srep31045
    53. Yao Lu, Dongyan Shao, Junling Shi, Qingsheng Huang, Hui Yang, Mingliang Jin. Strategies for enhancing resveratrol production and the expression of pathway enzymes. Applied Microbiology and Biotechnology 2016, 100 (17) , 7407-7421. https://doi.org/10.1007/s00253-016-7723-1
    54. Yu Miao, Liu Hong‐zhi, Yang Ying, Shi Ai‐min, Liu Li, Hu Hui, Wang Qiang, Yu Hong‐wei, Wang Xiao‐he. Optimising germinated conditions to enhance yield of resveratrol content in peanut sprout using response surface methodology. International Journal of Food Science & Technology 2016, 51 (8) , 1754-1761. https://doi.org/10.1111/ijfs.13099
    55. Mihir Halder, Sumita Jha. Enhanced trans-resveratrol production in genetically transformed root cultures of Peanut (Arachis hypogaea L.). Plant Cell, Tissue and Organ Culture (PCTOC) 2016, 124 (3) , 555-572. https://doi.org/10.1007/s11240-015-0914-0
    56. Christelle M. Andre, Jean-Francois Hausman, Gea Guerriero. Cannabis sativa: The Plant of the Thousand and One Molecules. Frontiers in Plant Science 2016, 7 https://doi.org/10.3389/fpls.2016.00019
    57. Adrián Matencio, Francisco García-Carmona, José Manuel López-Nicolás. Encapsulation of piceatannol, a naturally occurring hydroxylated analogue of resveratrol, by natural and modified cyclodextrins. Food & Function 2016, 7 (5) , 2367-2373. https://doi.org/10.1039/C6FO00557H
    58. Ji-Ah Kim, Kee-Hwa Bae, Yong-Eui Choi. Effect of elicited by methyl jasmonate on the saponin contents of Codonopsis lanceolata. Journal of Plant Biotechnology 2015, 42 (3) , 265-270. https://doi.org/10.5010/JPB.2015.42.3.265
    59. Judith M. Ball, Fabricio Medina-Bolivar, Katelyn Defrates, Emily Hambleton, Megan E. Hurlburt, Lingling Fang, Tianhong Yang, Luis Nopo-Olazabal, Richard L. Atwill, Pooja Ghai, Rebecca D. Parr. Investigation of Stilbenoids as Potential Therapeutic Agents for Rotavirus Gastroenteritis. Advances in Virology 2015, 2015 , 1-10. https://doi.org/10.1155/2015/293524
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