Abstract
The development of a supportive vasculature is essential for tumor progression. In a mouse model of breast cancer, we found that tumor-associated macrophages that are recruited to the tumor just before malignant conversion are essential for the angiogenic switch. These findings establish a causal linkage to explain well-documented clinical correlations between macrophages, microvessel density, and poor prognosis in breast tumors.
Publication types
- Research Support, N.I.H., Extramural
MeSH terms
- Animals
- Cell Transformation, Neoplastic / immunology
- Cell Transformation, Neoplastic / pathology*
- Disease Models, Animal
- Macrophages / immunology
- Macrophages / pathology*
- Mammary Neoplasms, Experimental / blood supply*
- Mammary Neoplasms, Experimental / immunology
- Mammary Neoplasms, Experimental / pathology
- Mice
- Mice, Transgenic
- Neovascularization, Pathologic / immunology
- Neovascularization, Pathologic / pathology