Reactive oxygen species and colorectal cancer
Sisi Lin
Department of Pathophysiology, Institute of Digestive Disease, Tongji University School of Medicine, Shanghai, China
Department of General, Visceral, and Transplant Surgery, Ludwig–Maximilians—University Munich, Munich, Germany
Search for more papers by this authorYongyu Li
Department of Pathophysiology, Institute of Digestive Disease, Tongji University School of Medicine, Shanghai, China
Search for more papers by this authorAndrey A. Zamyatnin Jr.
Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia
Department of Cell Signalling, Belozersky Institute of Physico–Chemical Biology, Lomonosov Moscow State University, Moscow, Russia
Search for more papers by this authorJens Werner
Department of General, Visceral, and Transplant Surgery, Ludwig–Maximilians—University Munich, Munich, Germany
German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany
Search for more papers by this authorCorresponding Author
Alexandr V. Bazhin
Department of General, Visceral, and Transplant Surgery, Ludwig–Maximilians—University Munich, Munich, Germany
German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany
Correspondence
Alexandr V. Bazhin, Department of General, Visceral, and Transplant Surgery, Ludwig–Maximilians—University Munich, 81377 Munich, Germany.
Email: [email protected]
Search for more papers by this authorSisi Lin
Department of Pathophysiology, Institute of Digestive Disease, Tongji University School of Medicine, Shanghai, China
Department of General, Visceral, and Transplant Surgery, Ludwig–Maximilians—University Munich, Munich, Germany
Search for more papers by this authorYongyu Li
Department of Pathophysiology, Institute of Digestive Disease, Tongji University School of Medicine, Shanghai, China
Search for more papers by this authorAndrey A. Zamyatnin Jr.
Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia
Department of Cell Signalling, Belozersky Institute of Physico–Chemical Biology, Lomonosov Moscow State University, Moscow, Russia
Search for more papers by this authorJens Werner
Department of General, Visceral, and Transplant Surgery, Ludwig–Maximilians—University Munich, Munich, Germany
German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany
Search for more papers by this authorCorresponding Author
Alexandr V. Bazhin
Department of General, Visceral, and Transplant Surgery, Ludwig–Maximilians—University Munich, Munich, Germany
German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany
Correspondence
Alexandr V. Bazhin, Department of General, Visceral, and Transplant Surgery, Ludwig–Maximilians—University Munich, 81377 Munich, Germany.
Email: [email protected]
Search for more papers by this authorAbstract
Colorectal cancer (CRC) has become the fourth leading cause of cancer-related death in the worldwide. It is urgent to find more effective therapeutic strategies for it. Reactive oxygen species (ROS) play multiple roles in normal cellular physiology processes. Thus, a certain level of ROS is essential to keep normal cellular function. However, the accumulation of ROS shows dual roles for cells, which is mainly dependent on the concentration of ROS, the origin of the cancer cell and the activated signaling pathways during tumor progression. In general, moderate level of ROS leads to cell damage, DNA mutation and inflammation, which promotes the initiation and development of cancer. Excessive high level of ROS induces cancer cell death, showing an anti-cancer role. ROS are commonly higher in CRC cells than their normal counterpart cells. Therefore, it is possible that ROS induce cell death in cancer cells while not affecting the normal cells, demonstrating lower side effects. Besides, ROS also play a role in tumor microenvironment and drug resistance. These multiple roles of ROS make them a promising therapeutic target for cancer. To explore potential ROS-target therapies against CRC, it is worth to comprehensively understanding the role of ROS in CRC and therapy. In this review, we mainly discuss the strategies of ROS in CRC therapy, including direct CRC cell target and indirect tumor environment target. In addition, the influences of ROS in drug resistance will also been discussed.
CONFLICTS OF INTEREST
The authors declare no conflicts of interest.
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