Title |
Nanoparticle Drones to Target Lung Cancer with Radiosensitizers and Cannabinoids
|
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Published in |
Frontiers in oncology, September 2017
|
DOI | 10.3389/fonc.2017.00208 |
Pubmed ID | |
Authors |
Wilfred Ngwa, Rajiv Kumar, Michele Moreau, Raymond Dabney, Allen Herman |
Abstract |
Nanotechnology has opened up a new, previously unimaginable world in cancer diagnosis and therapy, leading to the emergence of cancer nanomedicine and nanoparticle-aided radiotherapy. Smart nanomaterials (nanoparticle drones) can now be constructed with capability to precisely target cancer cells and be remotely activated with radiation to emit micrometer-range missile-like electrons to destroy the tumor cells. These nanoparticle drones can also be programmed to deliver therapeutic payloads to tumor sites to achieve optimal therapeutic efficacy. In this article, we examine the state-of-the-art and potential of nanoparticle drones in targeting lung cancer. Inhalation (INH) (air) versus traditional intravenous ("sea") routes of navigating physiological barriers using such drones is assessed. Results and analysis suggest that INH route may offer more promise for targeting tumor cells with radiosensitizers and cannabinoids from the perspective of maximizing damage to lung tumors cells while minimizing any collateral damage or side effects. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 8 | 15% |
Canada | 4 | 8% |
Portugal | 3 | 6% |
Switzerland | 2 | 4% |
Australia | 1 | 2% |
South Africa | 1 | 2% |
Iceland | 1 | 2% |
Unknown | 33 | 62% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 48 | 91% |
Practitioners (doctors, other healthcare professionals) | 3 | 6% |
Scientists | 1 | 2% |
Unknown | 1 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 66 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 12 | 18% |
Researcher | 11 | 17% |
Student > Ph. D. Student | 10 | 15% |
Student > Bachelor | 5 | 8% |
Student > Doctoral Student | 4 | 6% |
Other | 4 | 6% |
Unknown | 20 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 12% |
Agricultural and Biological Sciences | 6 | 9% |
Medicine and Dentistry | 6 | 9% |
Biochemistry, Genetics and Molecular Biology | 4 | 6% |
Physics and Astronomy | 4 | 6% |
Other | 15 | 23% |
Unknown | 23 | 35% |