User profiles for author:"Lina Zgaga"
Lina Zgaga
Trinity College Dublin
Verified email at tcd.ie
Cited by 24550
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Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials
Objective To evaluate the breadth, validity, and presence of biases of the associations of
vitamin D with diverse outcomes. Design Umbrella review of the evidence across systematic …
vitamin D with diverse outcomes. Design Umbrella review of the evidence across systematic …
[PDF][PDF] Abundant pleiotropy in human complex diseases and traits
S Sivakumaran, F Agakov, E Theodoratou… - The American Journal of …, 2011 - cell.com
We present a systematic review of pleiotropy among SNPs and genes reported to show
genome-wide association with common complex diseases and traits. We find abundant …
genome-wide association with common complex diseases and traits. We find abundant …
[HTML][HTML] The impact of vitamin D pathway genetic variation and circulating 25-hydroxyvitamin D on cancer outcome: systematic review and meta-analysis
PG Vaughan-Shaw, F O'sullivan, SM Farrington… - British journal of …, 2017 - nature.com
Background: Vitamin D has been linked with improved cancer outcome. This systematic
review and meta-analysis investigates the relationship between cancer outcomes and both …
review and meta-analysis investigates the relationship between cancer outcomes and both …
[HTML][HTML] Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts
KS Vimaleswaran, DJ Berry, C Lu, E Tikkanen… - PLoS …, 2013 - journals.plos.org
Background Obesity is associated with vitamin D deficiency, and both are areas of active
public health concern. We explored the causality and direction of the relationship between …
public health concern. We explored the causality and direction of the relationship between …
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout
V Vitart, I Rudan, C Hayward, NK Gray, J Floyd… - Nature …, 2008 - nature.com
Uric acid is the end product of purine metabolism in humans and great apes, which have lost
hepatic uricase activity, leading to uniquely high serum uric acid concentrations (200–500 …
hepatic uricase activity, leading to uniquely high serum uric acid concentrations (200–500 …
New loci associated with kidney function and chronic kidney disease
A Köttgen, C Pattaro, CA Böger, C Fuchsberger… - Nature …, 2010 - nature.com
Chronic kidney disease (CKD) is a significant public health problem, and recent genetic
studies have identified common CKD susceptibility variants. The CKDGen consortium …
studies have identified common CKD susceptibility variants. The CKDGen consortium …
Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Smoking is a leading global cause of disease and mortality. We established the Oxford-
GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP …
GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP …
Genome-wide association study identifies five loci associated with lung function
Pulmonary function measures are heritable traits that predict morbidity and mortality and
define chronic obstructive pulmonary disease (COPD). We tested genome-wide association …
define chronic obstructive pulmonary disease (COPD). We tested genome-wide association …
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide
association studies in 87,802 women of European descent, with replication in up to 14,731 …
association studies in 87,802 women of European descent, with replication in up to 14,731 …
FTO genotype is associated with phenotypic variability of body mass index
There is evidence across several species for genetic control of phenotypic variation of
complex traits,,,, such that the variance among phenotypes is genotype dependent …
complex traits,,,, such that the variance among phenotypes is genotype dependent …