User profiles for author:"Lina Zgaga"

Lina Zgaga

Trinity College Dublin
Verified email at tcd.ie
Cited by 24550

Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials

E Theodoratou, I Tzoulaki, L Zgaga, JPA Ioannidis - Bmj, 2014 - bmj.com
Objective To evaluate the breadth, validity, and presence of biases of the associations of
vitamin D with diverse outcomes. Design Umbrella review of the evidence across systematic …

[PDF][PDF] Abundant pleiotropy in human complex diseases and traits

S Sivakumaran, F Agakov, E Theodoratou… - The American Journal of …, 2011 - cell.com
We present a systematic review of pleiotropy among SNPs and genes reported to show
genome-wide association with common complex diseases and traits. We find abundant …

[HTML][HTML] The impact of vitamin D pathway genetic variation and circulating 25-hydroxyvitamin D on cancer outcome: systematic review and meta-analysis

PG Vaughan-Shaw, F O'sullivan, SM Farrington… - British journal of …, 2017 - nature.com
Background: Vitamin D has been linked with improved cancer outcome. This systematic
review and meta-analysis investigates the relationship between cancer outcomes and both …

[HTML][HTML] Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts

KS Vimaleswaran, DJ Berry, C Lu, E Tikkanen… - PLoS …, 2013 - journals.plos.org
Background Obesity is associated with vitamin D deficiency, and both are areas of active
public health concern. We explored the causality and direction of the relationship between …

SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout

V Vitart, I Rudan, C Hayward, NK Gray, J Floyd… - Nature …, 2008 - nature.com
Uric acid is the end product of purine metabolism in humans and great apes, which have lost
hepatic uricase activity, leading to uniquely high serum uric acid concentrations (200–500 …

New loci associated with kidney function and chronic kidney disease

A Köttgen, C Pattaro, CA Böger, C Fuchsberger… - Nature …, 2010 - nature.com
Chronic kidney disease (CKD) is a significant public health problem, and recent genetic
studies have identified common CKD susceptibility variants. The CKDGen consortium …

Meta-analysis and imputation refines the association of 15q25 with smoking quantity

JZ Liu, F Tozzi, DM Waterworth, SG Pillai, P Muglia… - Nature …, 2010 - nature.com
Smoking is a leading global cause of disease and mortality. We established the Oxford-
GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP …

Genome-wide association study identifies five loci associated with lung function

E Repapi, I Sayers, LV Wain, PR Burton, T Johnson… - Nature …, 2010 - nature.com
Pulmonary function measures are heritable traits that predict morbidity and mortality and
define chronic obstructive pulmonary disease (COPD). We tested genome-wide association …

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

CE Elks, JRB Perry, P Sulem, DI Chasman… - Nature …, 2010 - nature.com
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide
association studies in 87,802 women of European descent, with replication in up to 14,731 …

FTO genotype is associated with phenotypic variability of body mass index

J Yang, RJF Loos, JE Powell, SE Medland… - Nature, 2012 - nature.com
There is evidence across several species for genetic control of phenotypic variation of
complex traits,,,, such that the variance among phenotypes is genotype dependent …