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Antrocamphin A, an Anti-inflammatory Principal from the Fruiting Body of Taiwanofungus camphoratus, and Its Mechanisms

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† Graduate Institute of Biotechnology, National Chung-Hsing University, Taichung, Taiwan
‡ Department of Forestry, National Chung-Hsing University, Taichung, Taiwan
§ Molecular and Biological Agricultural Sciences Program, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan
# School of Forestry and Resource Conservation, National Taiwan University, Taipei, Taiwan
⊥ School of Chinese Medicine Resources, China Medical University, Taichung, Taiwan
∥ Department of Food Science and Biotechnology, National Chung-Hsing University, Taichung, Taiwan
△ Graduate Institute of Chinese Pharmaceutical Science, China Medical University, Taichung, Taiwan
⊗ Experimental Forest, College of Bio-Resources and Agriculture, National Taiwan University, Taiwan
*Corresponding authors [(Y.-H.K.) telephone +886-4-22053366 (ext. 5701), fax +886-4-22071693, e-mail [email protected]; (S.-Y.W.) telephone +886-4-22840345 (ext. 138), fax +886-4-22873628, e-mail [email protected]].
Cite this: J. Agric. Food Chem. 2010, 58, 5, 3153–3158
Publication Date (Web):February 3, 2010
https://doi.org/10.1021/jf903638p
Copyright © 2010 American Chemical Society
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    Abstract

    The fungus Taiwanofungus camphoratus is commonly used for medicinal purposes in Taiwan. It is used as a detoxicant for food poisoning and considered to be a precious folk medicine for hepatoprotection and anti-inflammation. In this study, a lipopolysaccaride (LPS)-challenged ICR mouse acute inflammation model and a LPS-induced macrophage model were used to evaluate the anti-inflammatory activity of T. camphoratus. Ethanol extract of T. camphoratus significantly inhibited expression of iNOS and COX-2 in the liver of LPS-challenged acute inflammatory mice. The ethyl acetate fraction and its isolated compound, antrocamphin A, significantly suppressed nitrite/nitrate concentration in LPS-challenged RAW 264.7 cells. Antrocamphin A showed potent anti-inflammatory activity by suppressing pro-inflammatory molecule release via the down-regulation of iNOS and COX-2 expression through the NF-κB pathway. This study, therefore, first demonstrates the bioactive compound of T. camphoratus and illustrates the mechanism by which it confers its anti-inflammatory activity.

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    Figure S1 (effects of 17 subfractions of the ethyl acetate extract of T. camphoratus on NO production in LPS-induced macrophages). This material is available free of charge via the Internet at http://pubs.acs.org.

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