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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Developmental Toxicity Assessment of Medicinal Mushroom Antrodia cinnamomea T.T. Chang et W.N. Chou (Higher Basidiomycetes) Submerged Culture Mycelium in Rats

Volume 13, Issue 6, 2011, pp. 505-511
DOI: 10.1615/IntJMedMushr.v13.i6.20
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ABSTRACT

Antrodia cinnamomea is a Taiwanese medicinal mushroom with high antioxidant and polysaccharide content. The objective of this study is to investigate developmental toxicity of A. cinnamomea in pregnant Sprague-Dawley rats. Animals were daily gavaged with A. cinnamomea mycelium at dosage levels of 0 (reverse osmosis water), 50, 150, and 500 mg/kg from gestation day (GD) 6 to 15. All dams were sacrificed on GD 20 and were subjected to cesarean section. Fetuses were examined for external, visceral, and skeletal abnormalities. All copulated females survived until the end of the study. No significant differences were recorded in body weight change, food consumption, and maternal gestational parameters. Only two fetal malformations were noted in 970 fetuses from the treatment groups. Some variations, such as enlarged fontanel, split sternebrae, absent sacral, absent caudal vertebral centra, absent thoracic centra, absent 13th−14th ribs, and fused ribs, were found during the skeletal examination, but no treatment-induced abnormalities occurred. No dose dependency was observed in any of the developmental variations. Overall observation of foetal malformations from rats given A. cinnamomea mycelium during pregnancy demonstrates that this material is not teratogenic at doses up to 500 mg/kg. It is concluded that A. cinnamomea BCRC 35398 mycelium has no teratogenic effects in female rats and is safe to be used as a functional food ingredient.

CITED BY
  1. Lu Mei-Chin, El-Shazly Mohamed, Wu Tung-Ying, Du Ying-Chi, Chang Tun-Tschu, Chen Chieh-Fu, Hsu Yu-Ming, Lai Kuei-Hung, Chiu Ching-Peng, Chang Fang-Rong, Wu Yang-Chang, Recent research and development of Antrodia cinnamomea, Pharmacology & Therapeutics, 139, 2, 2013. Crossref

  2. Chang Ching-Wen, Chen Yu-Syuan, Chen Chien-Chih, Chen Chin-Chu, Sheu Sen-Je, Lin Ting-wei, Lee Te-Chang, Lo Jeng-Fan, Lyophilized particles and ethanolic extracts of Antrodia cinnamomea mycelia suppress the tumorigenicity of head and neck cancer cells in vivo, BioMedicine, 4, 4, 2014. Crossref

  3. Lin Chin-Chung, Kumar K.J. Senthil, Liao Jiunn-Wang, Kuo Yueh-Hsiung, Wang Sheng-Yang, Genotoxic, teratotoxic and oral toxic assessments of Antrodia cinnamomea health food product (Leader Deluxe Antrodia cinnamomea ® ), Toxicology Reports, 2, 2015. Crossref

  4. Tsai Ming-Yen, Hung Yu-Chiang, Chen Yen-Hao, Chen Yung-Hsiang, Huang Yu-Chuen, Kao Chao-Wei, Su Yu-Li, Chiu Hsien-Hsueh Elley, Rau Kun-Ming, A preliminary randomised controlled study of short-term Antrodia cinnamomea treatment combined with chemotherapy for patients with advanced cancer, BMC Complementary and Alternative Medicine, 16, 1, 2016. Crossref

  5. Chen Chin-Chu, Li I-Chen, Lin Ting-Wei, Chang Hsiao-Ling, Lin Wen-Hsin, Shen You-Cheng, Efficacy and safety of oral Antrodia cinnamomea mycelium in mildly hypertensive adults: A randomized controlled pilot clinical study, European Journal of Integrative Medicine, 8, 5, 2016. Crossref

  6. Lin Yu-Hsing, Senthil Kumar K.J., Gokila Vani M., Liao Jiunn-Wang, Lin Chin-Chung, Kuo Jong-Tar, Wang Sheng-Yang, <i>In vitro </i>and <i>in vivo</i> toxicological assessments of <i>Antrodia cinnamomea</i> health food product (Leader <i>Antrodia cinnamomea</i> Capsule), Fundamental Toxicological Sciences, 3, 5, 2016. Crossref

  7. 林 定威, Prenatal Developmental Toxicity Study for a Mushroom Mycelia Complex Drink in Rats, Hans Journal of Food and Nutrition Science, 07, 02, 2018. Crossref

  8. Chiu Chen-Yuan, Chiu Hsien-Chun, Liu Shing-Hwa, Lan Kuo-Cheng, Prenatal developmental toxicity study of strontium citrate in Sprague Dawley rats, Regulatory Toxicology and Pharmacology, 101, 2019. Crossref

  9. Kuang Yi, Li Bin, Wang Zilong, Qiao Xue, Ye Min, Terpenoids from the medicinal mushroom Antrodia camphorata: chemistry and medicinal potential, Natural Product Reports, 38, 1, 2021. Crossref

  10. Liao Yu-Tso, Huang Kai-Wen, Chen Wan-Jing, Lai Tzung-Hsien, A Botanical Drug Extracted From Antrodia cinnamomea: A First-in-human Phase I Study in Healthy Volunteers, Journal of the American Nutrition Association, 2022. Crossref

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