Interferons, interferon-like cytokines, and their receptors
Corresponding Author
Sidney Pestka
Department of Molecular Genetics, Microbiology, and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ, USA.
PBL Biomedical Laboratories, Piscataway, NJ, USA.
Cancer Institute of New Jersey, New Brunswick, NJ, USA.
* Sidney PetskaDepartment of Molecular Genetics, Microbiology, and Immunology
University of Medicine and Dentistry of New Jersey
Robert Wood Johnson Medical School
675 Hoes Lane
Piscataway, NJ 08854-5635, USA
Tel.: +1 732 235 4567
Fax: +1 732 235 5223
E-mail: [email protected]Search for more papers by this author
Christopher D. Krause
Department of Molecular Genetics, Microbiology, and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ, USA.
Search for more papers by this authorMark R. Walter
Department of Molecular Genetics, Microbiology, and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ, USA.
Search for more papers by this authorCorresponding Author
Sidney Pestka
Department of Molecular Genetics, Microbiology, and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ, USA.
PBL Biomedical Laboratories, Piscataway, NJ, USA.
Cancer Institute of New Jersey, New Brunswick, NJ, USA.
* Sidney PetskaDepartment of Molecular Genetics, Microbiology, and Immunology
University of Medicine and Dentistry of New Jersey
Robert Wood Johnson Medical School
675 Hoes Lane
Piscataway, NJ 08854-5635, USA
Tel.: +1 732 235 4567
Fax: +1 732 235 5223
E-mail: [email protected]Search for more papers by this author
Christopher D. Krause
Department of Molecular Genetics, Microbiology, and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ, USA.
Search for more papers by this authorMark R. Walter
Department of Molecular Genetics, Microbiology, and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ, USA.
Search for more papers by this authorAbstract
Summary: Recombinant interferon-α (IFN-α) was approved by regulatory agencies in many countries in 1986. As the first biotherapeutic approved, IFN-α paved the way for the development of many other cytokines and growth factors. Nevertheless, understanding the functions of the multitude of human IFNs and IFN-like cytokines has just touched the surface. This review summarizes the history of the purification of human IFNs and the key aspects of our current state of knowledge of human IFN genes, proteins, and receptors. All the known IFNs and IFN-like cytokines are described [IFN-α, IFN-β, IFN-ε, IFN-κ, IFN-ω, IFN-δ, IFN-τ, IFN-γ, limitin, interleukin-28A (IL-28A), IL-28B, and IL-29] as well as their receptors and signal transduction pathways. The biological activities and clinical applications of the proteins are discussed. An extensive section on the evolution of these molecules provides some new insights into the development of these proteins as major elements of innate immunity. The overall structure of the IFNs is put into perspective in relation to their receptors and functions.
References
- 1 Isaacs A, Lindenmann J. Virus interference. I. The interferon. Proc R Soc Lond Ser B Biol Sci 1957; 147: 258–267.
- 2 Pestka S, Langer JA, Zoon KC, Samuel CE. Interferons and their actions. Annu Rev Biochem 1987; 56: 727–777.
- 3 Pestka S. Cloning of human interferons. In: S Pestka, ed. Methods in Enzymology, 79 edn. New York: Academic Press, 1981: 599–601.
- 4 Pestka S. Interferon from 1981 to 1986. In: S Pestka, ed. Methods in Enzymology, 119 edn. New York: Academic Press, 1986: 3–14.
- 5 Pestka S. The human interferons – from protein purification and sequence to cloning and expression in bacteria: before, between, beyond. Arch Biochem Biophys 1983; 221: 1–37.
- 6 Pestka S. The human interferon α species and receptors. Biopolymers 2000; 55: 254–287.
- 7 Stark GR, Kerr IM, Williams BR, Silverman RH, Schreiber RD. How cells respond to interferons. Annu Rev Biochem 1998; 67: 227–264.
- 8 Lefevre F, Guillomot M, D'Andrea S, Battegay S, La Bonnardiere C. Interferon-δ: the first member of a novel type I interferon family. Biochimie 1998; 80: 779–788.
- 9 Roberts RM, Cross JC, Leaman DW. Unique features of the trophoblast interferons. Pharmacol Ther 1991; 51: 329–345.
- 10 Oritani K, et al. Limitin: an interferon-like cytokine that preferentially influences B-lymphocyte precursors. Nat Med 2000; 6: 659–666.
- 11 LaFleur DW, et al. Interferon-κ, a novel type I interferon expressed in human keratinocytes. J Biol Chem 2001; 276: 39765–39771.
- 12 Ozato K, Tsujimura H, Tamura T. Toll-like receptor signaling and regulation of cytokine gene expression in the immune system. Biotechniques 2002; 66–68,70,72.
- 13 Kotenko SV, et al. IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex. Nat Immunol 2003; 4: 69–77.
- 14 Sheppard P, et al. IL-28, IL-29 and their class II cytokine receptor IL-28R. Nat Immunol 2003; 4: 63–68.
- 15 Chen J, Wood WI. Interferon PRO655. Genentech. [US 6,300,475], 1–37, 2003 [Patent].
- 16 Hardy MP, Owczarek CM, Jermiin L, Ejdebäck M, Hertzog PJ. Characterization of the type I interferon locus and identification of novel genes. Genomics 2004; 84: 331–345.
- 17 Cross JC, Farin CE, Sharif SF, Roberts RM. Characterization of the antiviral activity constitutively produced by murine conceptuses: absence of placental mRNAs for interferon alpha and beta. Mol Reprod Dev 1990; 26: 122–128.
- 18 Bakhutashvili VI, Merabishvili DG, Gogitashvili RV, Korsantiia BM, Dzotsenidze LL. [Physicochemical and biological properties of human placental amniotic interferon]. Vopr Virusol 1985; 30: 693–697.
- 19 Duc-Goiran P, Chany C, Doly J. Unusually large interferon-alpha-like mRNAs and high expression of interleukin-6 in human fetal annexes. J Biol Chem 1989; 264: 16507–16511.
- 20 Duc-Goiran P, Lebon P, Chany C. Measurement of interferon in human amniotic fluid and placental blood extract. Methods Enzymol 1986; 119: 541–551.
- 21 Cavalieri RL, Havell EA, Vilcek J, Pestka S. Induction and decay of human fibroblast interferon mRNA. Proc Natl Acad Sci USA 1977; 74: 4415–4419.
- 22 Fujita T, Ohno S, Yasumitsu H, Taniguchi T. Delimitation and properties of DNA sequences required for the regulated expression of human interferon-beta gene. Cell 1985; 41: 489–496.
- 23 Maniatis T. Mechanisms of human beta-interferon gene regulation. Harvey Lect 1986; 82: 71–104.
- 24 Young HA, Ghosh P. Molecular regulation of cytokine gene expression: interferon-gamma as a model system. Prog Nucleic Acid Res Mol Biol 1997; 56: 109–127.
- 25 Ben Asouli Y, Banai Y, Pel-Or Y, Shir A, Kaempfer R. Human interferon-gamma mRNA autoregulates its translation through a pseudoknot that activates the interferon-inducible protein kinase PKR. Cell 2002; 108: 221–232.
- 26 Kaempfer R. RNA sensors: novel regulators of gene expression. EMBO Rep 2003; 4: 1043–1047.
- 27 Berg K. Purification and characterization of murine and human interferons. A review of the literature of the 1970s. Acta Pathol Microbiol Immunol Scand Suppl 1982; 279: 1–136.
- 28 Rubinstein M, Rubinstein S, Familletti PC, Miller RS, Waldman AA. Human leukocyte interferon purified to homogeneity. Science 1978; 202: 1289–1290.
- 29 Rubinstein M, Rubinstein S, Familletti PC, Miller RS, Waldman AA, Pestka S. Human leukocyte interferon: production, purification to homogeneity, and initial characterization. Proc Natl Acad Sci USA 1979; 76: 640–644.
- 30 Rubinstein M, et al. Human leukocyte interferon: isolation characterization several molecular forms. Arch Biochem Biophys 1981; 210: 307–318.
- 31 Stein S, Kenny C, Friesen HJ, Shively J, Del Valle U, Pestka S. NH2-terminal amino acid sequence of human fibroblast interferon. Proc Natl Acad Sci USA 1980; 77: 5716–5719.
- 32 Friesen H-J, Stein S, Pestka S. Purification of human. Fibroblast interferon by high-performance liquid chromatography. In: S Pestka, ed. Methods in Enzymology, 78, edn. New York: Academic Press, 1981: 430–435.
- 33 Evinger M, Rubinstein M, Pestka S. Antiproliferative and antiviral activities of human leukocyte interferons. Arch Biochem Biophys 1981; 210: 319–329.
- 34 Maeda S, et al. Construction and identification of bacterial plasmids containing nucleotide sequence for human leukocyte interferon. Proc Natl Acad Sci USA 1980; 77: 7010–7013.
- 35 Goeddel DV, Pestka S. Microbial production of mature human leukocyte interferon K and L. Hoffmann-La Roche. [US 4,801,685], 1, 1989 [Patent].
- 36 Henco K, et al. Structural relationship of human interferon alpha genes and pseudogenes. J Mol Biol 1985; 185: 227–260.
- 37 Pestka S. The human interferon-α species and hybrid proteins. Semin Oncol 1997; 24: S9.
- 38 Pestka S. The purification and manufacture of human interferons. Sci Am 1983; 249: 36–43.
- 39 Diaz MO, et al. Structure of the human type-I interferon gene cluster determined from a YAC clone contig. Genomics 1994; 22: 540–552.
- 40 Pestka S. Human leukocyte interferon Hu-IFN-α.001. PBL Biomedical Laboratories. [US 5,789,551], 1, 1998 [Patent].
- 41 Pestka S. DNA encoding human interferon-α001. PBL Biomedical Laboratories. [US 5,869,293], 1, 1999 [Patent].
- 42 Pestka S. Method of identifying proteins modified by disease states related thereto. PBL Biomedical Laboratories. [US 6,001,589], 1999 [Patent].
- 43 Pestka S. Mutant human interferons. PBL Biomedical Laboratories. [US 6,299,870], 1–17, 2001 [Patent].
- 44 Pestka S. Modified interferons. PBL Biomedical Laboratories. [US 6,300,474], 1–22, 2001 [Patent].
- 45 Ortaldo JR, et al. A species of human α interferon that lacks the ability to boost human natural killer activity. Proc Natl Acad Sci USA 1984; 81: 4926–4929.
- 46 Pestka S, et al. Human interferon: the messenger RNA and the proteins. In: De Weck AL, Kristensen F, Landy M, eds. Biochemical Characterization of Lymphokines. New York: Academic Press, 1980: 315–321.
- 47 Pestka S, Evinger M, McCandliss R, Sloma A, Rubinstein M. Human interferon: the messenger RNA and the proteins. In: Beers RF, Bassett EG, eds. Polypeptide Hormones. New York: Raven Press 1980, 33–48.
- 48 Evinger M, Rubinstein M, Pestka S. Properties and clinical uses. In:Khan A, Hill NO, Dorn GL, eds. Dallas, Texas: Leland Fikes Foundation Press, 1980: 249–263.
- 49 Evinger M, Rubinstein M, Pestka S. Growth-inhibitory and antiviral activity of purified leukocyte interferon. Ann N Y Acad Sci 1980; 350: 399–404.
- 50 Evinger M, Pestka S. Assay of growth inhibition in lymphoblastoid cell cultures. In: S Pestka, ed. Methods in Enzymology, 79 edn. New York: Academic Press, 1981: 362–368.
- 51 Ortaldo JR, et al. Effects of recombinant and hybrid recombinant human leukocyte interferons on cytotoxic activity of natural killer cells. J Biol Chem 1983; 258: 15011–15015.
- 52 Ortaldo JR, Mantovani A, Hobbs D, Rubinstein M, Pestka S, Herberman RB. Effects of several species of human leukocyte interferon on cytotoxic activity of NK cells and monocytes. Int J Cancer 1983; 31: 285–289.
- 53 Rehberg E, Kelder B, Hoal EG, Pestka S. Specific molecular activities of recombinant and hybrid leukocyte interferons. J Biol Chem 1982; 257: 11497–11502.
- 54 Herberman RB, Ortaldo JR, Mantovani A, Hobbs DS, Kung H-F, Pestka S. Effect of human recombinant interferon on cytotoxic activity of natural killer (NK) cells and monocytes. Cell Immunol 1982; 67: 160–167.
- 55 Ortaldo JR, Herberman RB, Pestka S. Augmentation of human natural killer cells with human leukocyte and human recombinant leukocyte interferon. In: RB Herberman, ed. NK Cells and Other Natural Effector Cells. New York: Academic Press, 1982: 1279–1283.
- 56 Hochkeppel HK, Gruetter M, Horisberger MA, Lazdins JK. Human IFN-alpha hybrids. Drugs Future 1992; 17: 899–914.
10.1358/dof.1992.017.10.195933 Google Scholar
- 57 Von Wussow P, Hochkeppel HK, Jakschies D, Rapp U, Franke M, Deicher H. Phase I study of a new recombinant hybrid IFN (alpha1/alpha2). Proc Am Soc Clin Oncol 1991; 32: 1532[Abstract].
- 58 Ritch PS, et al. Phase I study IFN alpha BDBB hybrid. Proc Am Soc Clin Oncol 1992; 11: 252.
- 59 Klein ML, Bartley TD, Lai PH, Lu HS. Structural characterization of recombinant consensus interferon-α. J Chromatogr 1988; 454: 205–215.
- 60 Ortaldo JR, et al. Augmentation of NK activity with recombinant and hybrid recombinant human leukocyte interferons. In: E De Maeyer, H Schellekens, eds. The Biology of the Interferon System. Amsterdam: Elsevier Science Publishers, 1983: 353–358.
- 61 Pestka S, Kelder B, Familletti PC, Moschera JA, Crowl R, Kempner ES. Molecular weight of the functional unit of human leukocyte, fibroblast, and immune interferons. J Biol Chem 1983; 258: 9706–9709.
- 62 Kempner ES, Pestka S. Radiation inactivation and target size analysis of interferons. In: S Pestka, ed. Methods in Enzymology, 119 edn. New York: Academic Press, 1986: 255–260.
- 63 Langer JA, Rashidbaigi A, Garotta G, Kempner E. Radiation inactivation of human gamma-interferon: cellular activation requires two dimers. Proc Natl Acad Sci USA 1994; 91: 5818–5822.
- 64 Pestka S, Kotenko SV, Muthukumaran G, Izotova L, Cook JR, Garotta G. The interferon γ (IFN-γ) receptor: a paradigm for the multichain cytokine receptor. Cytokine Growth Factor Rev 1997; 8: 189–206.
- 65 Pestka S. The interferon receptors. Semin Oncol 1997; 24: S9.
- 66 Uze G, Lutfalla G, Gresser I. Genetic transfer of a functional human interferon α receptor into mouse cells: cloning and expression of its cDNA. Cell 1990; 60: 225–234.
- 67 Soh J, et al. Expression of a functional human type I interferon receptor in hamster cells: application of functional yeast artificial chromosome (YAC) screening. J Biol Chem 1994; 269: 18102–18110.
- 68 Cleary CM, Donnelly RJ, Soh J, Mariano TM, Pestka S. Knockout and reconstitution of a functional human type I interferon receptor complex. J Biol Chem 1994; 269: 18747–18749.
- 69 Domanski P, et al. Cloning and expression of a long form of the β subunit of the interferon αβ receptor that is required for signaling. J Biol Chem 1995; 270: 21606–21611.
- 70 Lutfalla G, et al. Mutant U5A cells are complemented by an interferon-αβ receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster. EMBO J 1995; 14: 5100–5108.
- 71 Jung V, Rashidbaigi A, Jones C, Tischfield JA, Shows TB, Pestka S. Human chromosomes 6 and 21 are required for sensitivity to human interferon gamma. Proc Natl Acad Sci USA 1987; 84: 4151–4155.
- 72 Darnell JE Jr. STATs and gene regulation. Science 1997; 277: 1630–1635.
- 73 Schindler C, Fu XY, Improta T, Aebersold R, Darnell JE Jr. Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon α. Proc Natl Acad Sci USA 1992; 89: 7836–7839.
- 74 Fu XY, Schindler C, Improta T, Aebersold R, Darnell JE Jr. The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. Proc Natl Acad Sci USA 1992; 89: 7840–7843.
- 75 Schindler C, Darnell JE Jr. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem 1995; 64: 621–651.
- 76 Pestka S, Krause CD, Sarkar D, Walter MR, Shi Y, Fisher PB. Interleukin-10 related cytokines receptors. Annu Rev Immunol 2004; 22: 929–979.
- 77 Dumoutier L, Lejeune D, Hor S, Fickenscher H, Renauld JC. Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT) 1, STAT2 and STAT3. Biochem J 2003; 370: 391–396.
- 78 Kawamoto S, et al. Antiviral activity of limitin against encephalomyocarditis virus, herpes simplex virus, and mouse hepatitis virus: diverse requirements by limitin and alpha interferon for interferon regulatory factor 1. J Virol 2003; 77: 9622–9631.
- 79 Nguyen KB, et al. Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection. Science 2002; 297: 2063–2066.
- 80 Su L, David M. Distinct mechanisms of STAT phosphorylation via the interferon-alpha/beta receptor. Selective inhibition of STAT3 and STAT5 by piceatannol. J Biol Chem 2000; 275: 12661–12666.
- 81 Yang CH, et al. Direct association of STAT3 with the IFNAR-1 chain of the human type I interferon receptor. J Biol Chem 1996; 271: 8057–8061.
- 82 Ziegler-Heitbrock L, Lotzerich M, Schaefer A, Werner T, Frankenberger M, Benkhart E. IFN-alpha induces the human IL-10 gene by recruiting both IFN regulatory factor 1 and Stat3. J Immunol 2003; 171: 285–290.
- 83 Taniguchi T, Takaoka A. The interferon-alpha/beta system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors. Curr Opin Immunol 2002; 14: 111–116.
- 84 Taniguchi T, Tanaka N, Ogasawara K, Taki S, Sato M, Takaoka A. Transcription factor IRF-1 and its family members in the regulation of host defense. Cold Spring Harb Symp Quant Biol 1999; 64: 465–472.
- 85 Kotenko SV, Pestka S. Jak-Stat signal transduction pathway through the eyes of cytokine class II receptor complexes. Oncogene 2000; 19: 2557–2565.
- 86 Stancato LF, David M, Carter-Su C, Larner AC, Pratt WB. Preassociation of STAT1 with STAT2 and STAT3 in separate signalling complexes prior to cytokine stimulation. J Biol Chem 1996; 271: 4134–4137.
- 87 Kirkwood JM, et al. Systemic interferon-alpha (IFN-alpha) treatment leads to Stat3 inactivation in melanoma precursor lesions. Mol Med 1999; 5: 11–20.
- 88 Takayanagi H, et al. RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta. Nature 2002; 416: 744–749.
- 89 Soh J, Donnelly RJ, Mariano TM, Cook JR, Schwartz B, Pestka S. Identification of a yeast artificial chromosome clone encoding an accessory factor for the human interferon gamma receptor: evidence for multiple accessory factors. Proc Natl Acad Sci USA 1993; 90: 8737–8741.
- 90 Soh J, et al. Identification and sequence of an accessory factor required for activation of the human interferon-γ receptor. Cell 1994; 76: 796–803.
- 91 Hemmi S, Bohni R, Stark G, Di Marco F, Aguet M. A novel member of the interferon receptor family complements functionality of the murine interferon γ receptor in human cells. Cell 1994; 76: 803–810.
- 92 Shuai K, Schindler C, Prezioso VR, Darnell JE Jr. Activation of transcription by IFN-γ: tyrosine phosphorylation of a 91-kD DNA binding protein. Science 1992; 258: 1808–1812.
- 93 Shuai K, Stark GR, Kerr IM, Darnell JE Jr. A single phosphotyrosine residue of Stat91 required for gene activation by interferon-γ. Science 1993; 261: 1744–1746.
- 94 Durbin JE, Hackenmiller R, Simon MC, Levy DE. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 1996; 84: 443–450.
- 95 Eilers A, Decker T. Activity of Stat family transcription factors is developmentally controlled in cells of the macrophage lineage. Immunobiology 1995; 193: 328–333.
- 96 Fountoulakis M, Zulauf M, Lusting A, Garotta G. Stoichiometry of interaction between interferon gamma and its receptor. Eur J Biochem 1992; 208: 781–787.
- 97 Marsters SA, Pennica D, Bach E, Schreiber RD, Ashkenazi A. Interferon gamma signals via a high-affinity multisubunit receptor complex that contains two types of polypeptide chain. Proc Natl Acad Sci USA 1995; 92: 5401–5405.
- 98 Krause CD, et al. Signaling by covalent heterodimers of interferon-gamma. Evidence for one-sided signaling in the active tetrameric receptor complex. J Biol Chem 2000; 275: 22995–23004.
- 99 Walter MR, et al. Crystal structure of a complex between interferon-γ and its soluble high-affinity receptor. Nature 1995; 376: 230–235.
- 100 Thiel DJ, et al. Observation of an unexpected third receptor molecule in the crystal structure of human interferon-γ receptor complex. Structure Fold Des 2000; 8: 927–936.
- 101 Randal M, Kossiakoff AA. The structure and activity of a monomeric interferon-γ: α-chain receptor signaling complex. Structure (Camb) 2001; 9: 155–163.
- 102 Cook JR, Jung V, Schwartz B, Wang P, Pestka S. Structural analysis of the human interferon gamma receptor: a small segment of the intracellular domain is specifically required for class I major histocompatibility complex antigen induction and antiviral activity. Proc Natl Acad Sci USA 1992; 89: 11317–11321.
- 103 Farrar MA, Campbell JD, Schreiber RD. Identification of a functionally important sequence in the C terminus of the interferon-gamma receptor. Proc Natl Acad Sci USA 1992; 89: 11706–11710.
- 104 Krause CD, et al. Seeing the light: preassembly and ligand-induced changes of the interferon γ receptor complex in cells. Mol Cell Proteomics 2002; 1: 805–815.
- 105 Braunstein J, Brutsaert S, Olson R, Schindler C. STATs dimerize in the absence of phosphorylation. J Biol Chem 2003; 278: 34133–34140.
- 106 Ota N, Brett TJ, Murphy TL, Fremont DH, Murphy KM. N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation. Nat Immunol 2004; 5: 208–215.
- 107 Nguyen H, Ramana CV, Bayes J, Stark GR. Roles of phosphatidylinositol 3-kinase in interferon-gamma-dependent phosphorylation of STAT1 on serine 727 and activation of gene expression. J Biol Chem 2001; 276: 33361–33368.
- 108 Yang CH, Murti A, Pfeffer SR, Kim JG, Donner DB, Pfeffer LM. Interferon alpha/beta promotes cell survival by activating nuclear factor kappa B through phosphatidylinositol 3-kinase and Akt. J Biol Chem 2001; 276: 13756–13761.
- 109 David M. Signal transduction by type I interferons. Biotechniques 2002; 58–65.
- 110 Sakatsume M, et al. Interferon gamma activation of Raf-1 is Jak1-dependent and p21ras-independent. J Biol Chem 1998; 273: 3021–3026.
- 111 Stancato LF, et al. Beta interferon and oncostatin M activate Raf-1 and mitogen-activated protein kinase through a JAK1-dependent pathway. Mol Cell Biol 1997; 17: 3833–3840.
- 112 Takaoka A, et al. Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence. Nature 2003; 424: 516–523.
- 113 Pestka S. A dance between interferon-alpha/beta and p53 demonstrates collaborations in tumor suppression and antiviral activities. Cancer Cell 2003; 4: 85–87.
- 114 Abramovich C, Yakobson B, Chebath J, Revel M. A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor. EMBO J 1997; 16: 260–266.
- 115 Pollack BP, Kotenko SV, He W, Izotova LS, Barnoski BL, Pestka S. The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity. J Biol Chem 1999; 274: 31531–31542.
- 116 Chung CD, et al. Specific inhibition of Stat3 signal transduction by PIAS3. Science 1997; 278: 1803–1805.
- 117 Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ. The SOCS box: a tale of destruction and degradation. Trends Biochem Sci 2002; 27: 235–241.
- 118 Kim TK, Maniatis T. Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway. Science 1996; 273: 1717–1719.
- 119 Ramana CV, Gil MP, Han Y, Ransohoff RM, Schreiber RD, Stark GR. Stat1-independent regulation of gene expression in response to IFN-gamma. Proc Natl Acad Sci USA 2001; 98: 6674–6679.
- 120 Gil MP, et al. Biologic consequences of Stat1-independent IFN signaling. Proc Natl Acad Sci USA 2001; 98: 6680–6685.
- 121 Aoki K, et al. Limitin, an interferon-like cytokine, transduces inhibitory signals on B-cell growth through activation of Tyk2, but not Stat1, followed by induction and nuclear translocation of Daxx. Exp Hematol 2003; 31: 1317–1322.
- 122 Kato K, et al. Intracellular signal transduction of interferon on the suppression of haematopoietic progenitor cell growth. Br J Haematol 2003; 123: 528–535.
- 123 Greiner JW, Hand PH, Noguchi P, Fisher PB, Pestka S, Schlom J. Enhanced expression of surface tumor-associated antigens on human breast and colon tumor cells after recombinant human leukocyte α-interferon treatment. Cancer Res 1984; 44: 3208–3214.
- 124 Greiner JW, et al. Modulation of tumor associated antigen expression and shedding by recombinant human leukocyte and fibroblast interferons. Pharmacol Ther 1985; 31: 209–236.
- 125 Greiner JW, et al. Recombinant interferon enhances monoclonal antibody-targeting carcinoma lesions in vivo. Science 1987; 235: 895–898.
- 126 Basham TY, Bourgeade MF, Creasey AA, Merigan TC. Interferon increases HLA synthesis in melanoma cells: interferon-resistant and -sensitive cell lines. Proc Natl Acad Sci USA 1982; 79: 3265–3269.
- 127 Dolei A, Capobianchi MR, Ameglio F. Human interferon-γ enhances the expression of class I and class II major histocompatibility complex products in neoplastic cells more effectively than interferon-α and interferon-β. Infect Immun 1983; 40: 172–176.
- 128 Ozzello L, DeRosa CM, Habif DV, Cantell K, Pestka S. Up-regulation of a tumor-associated antigen (TAG-72) by interferons alpha and gamma in patients with cutaneous breast cancer recurrences. Int J Oncol 1995; 6: 985–991.
- 129 Clemens MJ. Interferons and apoptosis. J Interferon Cytokine Res 2003; 23: 277–292.
- 130 Keay S, Grossberg SE. Interferon inhibits the conversion of 3T3-L1 mouse fibroblasts into adipocytes. Proc Natl Acad Sci USA 1980; 77: 4099–4103.
- 131 Fisher PB, Hermo H Jr, Prignoli DR, Weinstein IB, Pestka S. Hybrid recombinant human leukocyte interferon inhibits differentiation in murine B-16 melanoma cells. Biochem Biophys Res Commun 1984; 119: 108–115.
- 132 Fisher PB, Prignoli DR, Hermo H Jr, Weinstein IB, Pestka S. Effects of combined treatment with interferon and mezerein on melanogenesis and growth in human melanoma cells. J Interferon Res 1985; 5: 11–22.
- 133 Fidler IJ. Regulation of neoplastic angiogenesis. J Natl Cancer Inst Monogr 2001; 10–14.
- 134 Kerbel R, Folkman J. Clinical translation of angiogenesis inhibitors. Nat Rev Cancer 2002; 2: 727–739.
- 135 Paredes J, Krown SE. Interferon-alpha therapy in patients with Kaposi's sarcoma and the acquired immunodeficiency syndrome. Int J Immunopharmacol 1991; 13: 77–81.
- 136 Talpaz M, Kantarjian H, McCredie K, Trujillo J, Keating M, Gutterman JU. Therapy of chronic myelogenous leukemia. Cancer 1987; 59: 664–667.
10.1002/1097-0142(19870201)59:3+<664::AID-CNCR2820591316>3.0.CO;2-Y CASPubMedWeb of Science®Google Scholar
- 137 Kirkwood JM, Ibrahim JG, Sondak VK, Ernstoff MS, Ross M. Interferon alfa-2a for melanoma metastases. Lancet 2002; 359: 978–979.
- 138 Sun W, Schuchter LM. Metastatic melanoma. Curr Treat Options Oncol 2001; 2: 193–202.
- 139 Dutcher J, et al. Kidney cancer: the Cytokine Working Group experience (1986–2001): part II. Management of IL-2 toxicity and studies with other cytokines. Med Oncol 2001; 18: 209–219.
- 140 Borden EC, Lindner D, Dreicer R, Hussein M, Peereboom D. Second-generation interferons for cancer: clinical targets. Semin Cancer Biol 2000; 10: 125–144.
- 141 Einhorn S, Strander H. Interferon treatment of human malignancies – a short review. Med Oncol Tumor Pharmacother 1993; 10: 25–29.
- 142 Pestka S. Type I interferons and receptors. In: M Steward, S Kaufmann, eds. Topley and Wilson Microbiology and Microbial Infection, 10th edn. London: Arnold Publishers, (in press).
- 143 Van Herpen CM, De Mulder PH. Locoregional immunotherapy in cancer patients: review of clinical studies. Ann Oncol 2000; 11: 1229–1239.
- 144 Mazzella G, et al. Long-term results with interferon therapy in chronic type B hepatitis: a prospective randomized trial. Am J Gastroenterol 1999; 94: 2246–2250.
- 145 Pianko S, McHutchison JG. Treatment of hepatitis C with interferon and ribavirin. J Gastroenterol Hepatol 2000; 15: 581–586.
- 146 Roffi L, et al. Breakthrough during recombinant interferon alfa therapy in patients with chronic hepatitis C virus infection: prevalence, etiology, and management. Hepatology 1995; 21: 645–649.
- 147 Yamamoto H, Hayashi E, Nakamura H, Kimura Y, Ito H, Kambe H. Interferon therapy for non-A, non-B hepatitis: a pilot study and review of the literature. Hepatogastroenterology 1992; 39: 377–380.
- 148 Enomoto N, et al. Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region. J Clin Invest 1995; 96: 224–230.
- 149 Gale MJ Jr, et al. Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein. Virology 1997; 230: 217–227.
- 150 Okamoto H, et al. Typing hepatitis C virus by polymerase chain reaction with type-specific primers: application to clinical surveys and tracing infectious sources. J Gen Virol 1992; 73: 673–679.
- 151 Hijikata M, Mishiro S, Miyamoto C, Furuichi Y, Hashimoto M, Ohta Y. Genetic polymorphism of the MxA gene promoter and interferon responsiveness of hepatitis C patients: revisited by analyzing two SNP sites (−123 and −88) in vivo and in vitro. Intervirology 2001; 44: 379–382.
- 152 Rockley PF, Tyring SK. Interferons alpha, beta and gamma therapy of anogenital human papillomavirus infections. Pharmacol Ther 1995; 65: 265–287.
- 153 Glezerman M, et al. Placebo-controlled trial of topical interferon in labial and genital herpes. Lancet 1988; 1: 150–152.
- 154 Ophir J, Brenner S, Bali R, Kriss-Leventon S, Smetana Z, Revel M. Effect of topical interferon-beta on recurrence rates in genital herpes: a double-blind, placebo-controlled, randomized study. J Interferon Cytokine Res 1995; 15: 625–631.
- 155 Lundquist PG, Haglund S, Carlsoo B, Strander H, Lundgren E. Interferon therapy in juvenile laryngeal papillomatosis. Otolaryngol Head Neck Surg 1984; 92: 386–391.
- 156 Hayden FG, Albrecht JK, Kaiser DL, Gwaltney JM Jr. Prevention of natural colds by contact prophylaxis with intranasal alpha 2-interferon. N Engl J Med 1986; 314: 71–75.
- 157 Scott GM, Phillpotts RJ, Wallace J, Gauci CL, Greiner J, Tyrrell DA. Prevention of rhinovirus colds by human interferon alpha-2 from Escherichia coli. Lancet 1982; 2: 186–188.
- 158 Masihi KN. Immunomodulators in infectious diseases: panoply of possibilities. Int J Immunopharmacol 2000; 22: 1083–1091.
- 159 Masihi KN. Fighting infection using immunomodulatory agents. Expert Opin Biol Ther 2001; 1: 641–653.
- 160 Sen GC, Herz R, Davatelis V, Pestka S. Antiviral and protein-inducing activities of recombinant human leukocyte interferons and their hybrids. J Virol 1984; 50: 445–450.
- 161 Sperber SJ, Gocke DJ, Haberzettl C, Kuk R, Schwartz B, Pestka S. Anti-HIV-1 activity of recombinant and hybrid species of interferon-alpha. J Interferon Res 1992; 12: 363–368.
- 162 Silberberg DH. Specific treatment of multiple sclerosis. Clin Neurosci 1994; 2: 271–274.
- 163 Wingerchuk DM, Noseworthy JH. Randomized controlled trails to assess therapies for multiple sclerosis. Neurology 2002; 58: S40–S48.
- 164 Leppert D, Waubant E, Burk MR, Oksenberg JR, Hauser SL. Interferon beta-1b inhibits gelatinase secretion and in vitro migration of human T cells: a possible mechanism for treatment efficacy in multiple sclerosis. Ann Neurol 1996; 40: 846–852.
- 165 Meraz MA, et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 1996; 84: 431–442.
- 166 Nathan PD, Gore ME, Eisen TG. Unexpected toxicity of combination thalidomide and interferon alpha-2a treatment in metastatic renal cell carcinoma. J Clin Oncol 2002; 20: 1429–1430.
- 167 Raanani P, Ben Bassat I. Immune-mediated complications during interferon therapy in hematological patients. Acta Haematol 2002; 107: 133–144.
- 168 Moschos SJ, Kirkwood JM, Konstantinopoulos PA. Present status and future prospects for adjuvant therapy of melanoma: time to build upon the foundation of high-dose interferon alfa-2b. J Clin Oncol 2004; 22: 11–14.
- 169 Antonelli G, et al. Interferon antibodies in patients with infectious diseases. Anti-interferon antibodies. Biotherapy 1997; 10: 7–14.
- 170 Dianzani F, Pestka S. A review of interferon immunogenicity. J Interferon Cytokine Res 1997; 17: S1–55.
- 171 Nolte KU, Jakschies D, Pestka S, Von Wussow P. Different specificities of SLE-derived and therapy-induced interferon-alpha antibodies. J Interferon Res 1994; 14: 197–199.
- 172 Viscomi GC, et al. Antigenic characterization of recombinant, lymphoblastoid, and leukocyte IFN-alpha by monoclonal antibodies. J Interferon Cytokine Res 1999; 19: 319–326.
- 173 Kaiser P, Wain HM, Rothwell L. Structure of the chicken interferon-γ gene, and comparison to mammalian homologues. Gene 1998; 207: 25–32.
- 174 Altmann SM, Mellon MT, Distel DL, Kim CH. Molecular and functional analysis of an interferon gene from the zebrafish, Danio rerio. J Virol 2003; 77: 1992–2002.
- 175 Lutfalla G, Crollius HR, Stange-Thomann N, Jaillon O, Mogensen K, Monneron D. Comparative genomic analysis reveals independent expansion of a lineage-specific gene family in vertebrates: the class II cytokine receptors and their ligands in mammals and fish. BMC Genomics 2003; 4: 29.
- 176 Robertsen B, Bergan V, Rokenes T, Larsen R, Albuquerque A. Atlantic salmon interferon genes: cloning, sequence analysis, expression, and biological activity. J Interferon Cytokine Res 2003; 23: 601–612.
- 177 Sick C, Schultz U, Staeheli P. A family of genes coding for two serologically distinct chicken interferons. J Biol Chem 1996; 271: 7635–7639.
- 178 Nanda I, et al. Sex chromosome linkage of chicken and duck type I interferon genes: further evidence of evolutionary conservation of the Z chromosome in birds. Chromosoma 1998; 107: 204–210.
- 179 Staeheli P, Puehler F, Schneider K, Gobel TW, Kaspers B. Cytokines of birds: conserved functions – a largely different look. J Interferon Cytokine Res 2001; 21: 993–1010.
- 180 Harrison GA, Young LJ, Watson CM, Miska KB, Miller RD, Deane EM. A survey of type I interferons from a marsupial and monotreme: implications for the evolution of the type I interferon gene family in mammals. Cytokine 2003; 21: 105–119.
- 181 Park C, Li S, Cha E, Schindler C. Immune response in Stat2 knockout mice. Immunity 2000; 13: 795–804.
- 182 Roberts RM, Ezashi T, Rosenfeld CS, Ealy AD, Kubisch HM. Evolution of the interferon τ genes and their promoters, and maternal-trophoblast interactions in control of their expression. Reprod Suppl 2003; 61: 239–251.
- 183 Nardelli B, et al. IFN-κ, a novel type I interferon. Eur Cytokine Netw 2000; 11: 39[Abstract].
- 184 Taya Y, Devos R, Tavernier J, Cheroutre H, Engler G, Fiers W. Cloning and structure of the human immune interferon-γ chromosomal gene. EMBO J 1982; 1: 953–958.
- 185 Gray PW, Goeddel DV. Structure of the human immune interferon gene. Nature 1982; 298: 859–863.
- 186 Reboul J, Gardiner K, Monneron D, Uze G, Lutfalla G. Comparative genomic analysis of the interferon/interleukin-10 receptor gene cluster. Genome Res 1999; 9: 242–250.
- 187 Suresh M, Karaca K, Foster D, Sharma JM. Molecular and functional characterization of turkey interferon. J Virol 1995; 69: 8159–8163.
- 188 Schultz U, Kock J, Schlicht HJ, Staeheli P. Recombinant duck interferon: a new reagent for studying the mode of interferon action against hepatitis B virus. Virology 1995; 212: 641–649.
- 189 Heller ED, Levy AM, Vaiman R, Schwartsburd B. Chicken-embryo fibroblasts produce two types of interferon upon stimulation with Newcastle disease virus. Vet Immunol Immunopathol 1997; 57: 289–303.
- 190 Bazan JF. Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci USA 1990; 87: 6934–6938.
- 191 Lutfalla G, Gardiner K, Proudhon D, Vielh E, Uze G. The structure of the human interferon α/β receptor gene. J Biol Chem 1992; 267: 2802–2809.
- 192 Nagata S, Mantei N, Weissmann C. The structure of one of the eight or more distinct chromosomal genes for human interferon-a. Nature 1980; 287: 401–408.
- 193 Galabov AS, Velichikova EH. Interferon production in tortoise peritoneal cells. J Gen Virol 1975; 28: 259–263.
- 194 Galabov A, Petrunova S, Savov Z. Molecular weight of virus-induced tortoise interferon in cell cultures. Experientia 1973; 29: 900–901.
- 195 Galabov A, Savov Z, Vassileva V. Interferon production in arbovirus-infected cell cultures of tortoise (Testudo graeca) kidney. Acta Virol 1973; 17: 1–10.
- 196 Oritani K, Kincade PW, Zhang C, Tomiyama Y, Matsuzawa Y. Type I interferons and limitin: a comparison of structures, receptors, and functions. Cytokine Growth Factor Rev 2001; 12: 337–348.
- 197 Oritani K, Kincade PW, Tomiyama Y. Limitin: an interferon-like cytokine without myeloerythroid suppressive properties. J Mol Med 2001; 79: 168–174.
- 198 Nomenclature Committee. ISICR Committee Minutes. ISICR Newsletter 2004; 11: 25–26.
- 199 Radhakrishnan R, et al. Zinc mediated dimer of human interferon-α2b revealed by X-ray crystallography. Structure 1996; 4: 1453–1463.
- 200 Klaus W, Gsell B, Labhardt AM, Wipf B, Senn H. The three-dimensional high resolution structure of human interferon α-2a determined by heteronuclear NMR spectroscopy in solution. J Mol Biol 1997; 274: 661–675.
- 201 Senda T, Saitoh S, Mitsui Y. Refined crystal structure of recombinant murine interferon-β at 2.15 Å resolution. J Mol Biol 1995; 253: 187–207.
- 202 Karpusas M, Nolte M, Benton CB, Meier W, Lipscomb WN, Goelz S. The crystal structure of human interferon β at 2.2-Å resolution. Proc Natl Acad Sci USA 1997; 94: 11813–11818.
- 203 Radhakrishnan R, Walter LJ, Subramaniam PS, Johnson HM, Walter MR. Crystal structure of ovine interferon-τ at 2.1 Å resolution. J Mol Biol 1999; 286: 151–162.
- 204 Cook JR, Cleary CM, Mariano TM, Izotova L, Pestka S. Differential responsiveness of a splice variant of the human type I interferon receptor to interferons. J Biol Chem 1996; 271: 13448–13453.
- 205 Darnell JE Jr, Kerr IM, Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994; 264: 1415–1421.
- 206 Pestka S, Kotenko SV, Muthukumaran G, Izotova LS, Cook JR, Garotta G. The interferon γ (IFN-γ) receptor: a paradigm for the multichain cytokine receptor. Cytokine Growth Factor Rev 1997; 8: 189–206.
- 207 Rashidbaigi A, et al. The gene for the human immune interferon receptor is located on chromosome 6. Proc Natl Acad Sci USA 1986; 83: 384–388.
- 208 Jung V, et al. Chromosome mapping of biological pathways by fluorescence-activated cell sorting and cell fusion: human interferon gamma receptor as a model system. Somat Cell Mol Genet 1988; 14: 583–592.
- 209 Jung V, Jones C, Kumar CS, Stefanos S, O'Connell S, Pestka S. Expression and reconstitution of a biologically active human interferon-gamma receptor in hamster cells. J Biol Chem 1990; 265: 1827–1830.
- 210 Lembo D, et al. Mouse macrophages carrying both subunits of the human interferon-gamma (IFN-gamma) receptor respond to human IFN-gamma but do not acquire full protection against viral cytopathic effect. J Biol Chem 1996; 271: 32659–32666.
- 211 Takayama T, et al. Mammalian and viral IL-10 enhance C-C chemokine receptor 5 but down-regulate C-C chemokine receptor 7 expression by myeloid dendritic cells: impact on chemotactic responses and in vivo homing ability. J Immunol 2001; 166: 7136–7143.
- 212 Touitou R, Cochet C, Joab I. Transcriptional analysis of the Epstein–Barr virus interleukin-10 homologue during the lytic cycle. J Gen Virol 1996; 77: 1163–1168.
- 213 Zou J, Clark MS, Secombes CJ. Characterisation, expression and promoter analysis of an interleukin 10 homologue in the puffer fish, Fugu rubripes. Immunogenetics 2003; 55: 325–335.
- 214 Kotenko SV. The family of IL-10-related cytokines and their receptors: related, but to what extent? Cytokine Growth Factor Rev 2002; 13: 223–240.
- 215 Orange S, Horvath J, Hennessy A. Preeclampsia is associated with a reduced interleukin-10 production from peripheral blood mononuclear cells. Hypertens Pregnancy 2003; 22: 1–8.
- 216 Liva SM, Voskuhl RR. Testosterone acts directly on CD4+ T lymphocytes to increase IL-10 production. J Immunol 2001; 167: 2060–2067.
- 217 Tilg H, et al. Treatment of Crohn's disease with recombinant human interleukin 10 induces the proinflammatory cytokine interferon gamma. Gut 2002; 50: 191–195.
- 218 Llorente L, et al. Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus. J Exp Med 1995; 181: 839–844.
- 219 Park YB, Lee SK, Kim DS, Lee J, Lee CH, Song CH. Elevated interleukin-10 levels correlated with disease activity in systemic lupus erythematosus. Clin Exp Rheumatol 1998; 16: 283–288.
- 220 Aguet M, Dembic Z, Merlin G. Molecular cloning and expression of the human interferon-γ receptor. Cell 1988; 55: 273–280.
- 221 Bach EA, Aguet M, Schreiber RD. The IFNγ receptor: a paradigm for cytokine receptor signaling. Annu Rev Immunol 1997; 15: 563–591.
- 222 Novick D, Cohen B, Rubenstein M. The human interferon α/β receptor: characterization and molecular cloning. Cell 1994; 77: 391–400.
- 223 Kotenko SV, Krause CD, Izotova LS, Pollack BP, Wu W, Pestka S. Identification and characterization of a second chain of the interleukin-10 receptor complex. EMBOJ 1997; 16: 5894–5903.
- 224 Lutfalla G, McInnis MG, Antonarakis SE, Uze G. Structure of the human CRFB4 gene: comparison with its IFNAR neighbor. J Mol Evol 1995; 41: 338–344.
- 225 Lutfalla G, Gardiner K, Uze G. A new member of the cytokine receptor gene family maps on chromosome 21 at less than 53 kb from IFNAR. Genomics 1993; 16: 366–373.
- 226 Ealick SE, et al. Three dimensional structure of recombinant human initerferon-γ. Science 1990; 252: 698–702.
- 227 Lander A, et al. Design, characterization, and structure of a biologically active single-chain mutant of human IFN-gamma. J Mol Biol 2000; 299: 169–179.
- 228 Randal M, Kossiakoff AA. The 2.0 A structure of bovine interferon-γ; assessment of the structural differences between species. Acta Crystallogr D Biol 2000; 56: 14–24.
- 229 Chill JH, Quandt SR, Levy R, Schreiber G, Anglister J. The human type I initerferon receptor: NMR structure reveals the molecular basis of ligand binding. Structure 11: 791–802.