Cardiovascular and Endothelial Effects of Fish Oil Supplementation in Healthy Volunteers
Abstract
Consumption of fish oil (FO) is associated with reduced adverse cardiovascular events. In a randomized, blinded, placebo-controlled trial, 26 subjects (17 men and 9 women; mean age [± SD] 31 ± 3.7 years) received 1 g FO capsule (n = 14) or placebo (1 g of corn oil, n = 12) for 14 days. At day 0 and day 14, heart rate (HR), blood pressure, endothelium-dependent brachial artery flow-mediated vasodilation (EDV), and endothelium-independent nitroglycerin-mediated vasodilation (EIDV) were assessed with ultrasound. FO supplementation resulted in a significant increase in EDV (20.4% ± 13.2% vs 9.9% ± 5.4%; P = .036) and EIDV (32.6% ± 16.8% vs 18.0% ± 14.9%; P = .043). Resting HR decreased by a mean of 5.9 ± 9.4 bpm (FO) compared with placebo (mean increase of 0.73 ± 4.8 bpm [P = .05]). FO supplementation in healthy subjects is associated with improved endothelial function and decreased resting HR.
References
Smith SC, Blair SN, Bonow RO, et al. AHA/ACC scientific statement: AHA/ACC guidelines for preventing heart attack and death in patients with atherosclerotic cardiovascular disease: 2006 update. Circulation. 2006; 113:2263-2272.
Daviglus ML, Stamler J., Orencia AJ, et al. Fish consumption and the 30-year risk of fatal myocardial infarction . N Engl J Med. 1997;336:1046-1053.
Albert CM, Hennekens CH, O'Donnell CJ, et al. Fish consumption and the risk of sudden death. JAMA. 1998;279:23-28.
Albert CM, Campos H., Stampfer MJ, et al. Blood levels of long-chain n-3 fatty acids and the risk of sudden death. N Engl J Med. 2002;346:1113-1118.
Burr ML, Fehily AM, Gilbert JF, et al. Effects of changes in fat, fish, and fibre intakes on death and myocardial infarction. Lancet. 1989;2:757-761.
Marchioli R., Barzi F., Bomba E., et al. Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione. Circulation. 2002;105:1897-1903.
Anderson TJ, Uehata A., Gerhard MD, et al. Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol. 1995;26: 1235-1241.
Lieberman EH, Uehata A. Flow mediated vasodilation is impaired in the brachial artery of patients with coronary artery disease or with diabetes mellitus. Clin Res. 1993; 41:217A.
Celermajer DS, Sorensen KE, Bull C., Robinson J., Deanfield JE Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis . Lancet . 1992;340:1111-1115.
Neunteufl T., Heher S., Katzenschlager R., Abela C., Niderle B., Stefenelli T. Late prognostic value of flow-mediated dilation in the brachial artery of patients with chest pain. Am J Cardiol. 2000 ;86:207-210.
Khan F., Elherik K., Bolton-Smith C., et al. The effects of dietary fatty acid supplementation on endothelial function and vascular tone in healthy subjects. Cardiovasc Res. 2003;59:955-962.
Reneman RS, Van Merode T, Hick P., Hoeks AP Agerelated changes in carotid wall properties in man. Ultrasound Med Biol. 1986;12:465-471.
Krauss RM, Eckel RH, Howard B., et al. AHA dietary guidelines: revision 2000: a statement for healthcare professionals from the Nutrition Committee of the American Heart Association . Circulation. 2000;102:2284-2299.
Wardlaw GM Perspectives in Nutrition. 4th ed. Boston: McGraw-Hill; 1999.
Eschen O., Christensen JH, De Caterina R, Schmidt EB Soluble adhesion molecules in healthy subjects: a dose-response study using n-3 fatty acids. Nutr Metab Cardiovasc Dis. 2004;14:180-185.
Cherry PD, Furchgott RF The role of endothelial cell in the relaxation of isolated arteries by bradykinin . Proc Natl Acad Sci U S A. 1983;79:2106-2110.
Rubanyi GM The role of endothelium in cardiovascular homeostasis and disease . J Cardiovasc Pharmacol. 1992; 22(suppl 4):S1-S14.
Vogel RA Coronary risk factors, endothelial function, and atherosclerosis, a review . Clin Cardiol. 1997;84:12721277.
Anderson TJ, Meredith IT, Yeung AC, Frei B., Selwyn AP, Ganz P. The effects of cholesterol lowering and antioxidant therapy on endothelium-dependent coronary vasomotion . N Engl J Med. 1995;332:488-493.
Woods RK, Thien FC, Abramson MJ Dietary marine fatty acids for asthma. Cochrane Database Syst Rev. 2000;(4): CD001283.
Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico . Lancet. 1999; 354:447-455.
Singh RB, Niaz MA, Sharma JP, Kumar R., Rastogi V., Moshiri M. Randomized, double-blind, placebo-controlled trial of fish oil and mustard oil in patients with suspected acute myocardial infarction: the Indian experiment of infarct survival-4. Cardiovasc Drugs Ther. 1997;11:485-491.
Bairati I., Roy L., Meyer F. Double-blind, randomized, controlled trial of fish oil supplements in prevention of recurrence of stenosis after coronary angioplasty. Circulation. 1992;85:950-956.
Farmer A., Montori V., Dinneen S., Clar C. Fish oil in people with type 2 diabetes mellitus. Cochrane Database Syst Rev. 2000;2:CD001283.
Goodfellow J., Bellamy MF, Ramsey MW, Jones CJ, Lewis MJ Dietary supplementation with marine ω-3 fatty acids improve systemic large artery endothelial function in subjects with hypercholesterolemia. J Am Coll Cardiol. 2000;35:265-270.
Goode GK, Garcia S., Heagerty AM Dietary supplementation with marine fish oil improves in vitro small artery endothelial function in hypercholesterolemic patients: a double blind placebo controlled study. Circulation. 1997 ;96:2802-2807.
Kang JX, Leaf A. Antiarrhythmic effects of polyunsaturated fatty acids: recent studies. Circulation. 1996;94: 1774-1780.
Black KL, Culp B., Madison D., Randall OS, Lands WE The protective effects of dietary fish oil on focal cerebral infarction . Prostaglandins Med. 1979;3:257-268.
Okuda Y., Kawashima K., Sawada T., et al. Eicosapentaenoic acid enhances nitric oxide production by cultured human endothelial cells. Biochem Biophys Res Commun. 1997; 232:487-491.
Uauy R., Mena P., Valenzuela A. Essential fatty acids as determinants of lipid requirements in infants, children and adults. Eur J Clin Nutr. 1999 ;53(suppl 1):S66-S77.
Bayon Y., Croset M., Daveloose D., et al. Effect of specific phospholipids molecular species incorportated in human platelet membranes on thromboxane A2/prostaglandin H2 receptors. J Lipid Res. 1995;36:47-56.
Billman GE, Kang JX, Leaf A. Prevention of ischemiainduced cardiac sudden death by n-3 polyunsaturated fatty acids in dogs. Lipids. 1997;32:1161-1168.
Dallongeville J., Yarnell J., Ducimetiere P., et al. Fish consumption is associated with lower heart rates. Circulation. 2003;108:820-825.
Albert CM, Hennekens CH, O'Donnell CJ, et al. Fish consumption and risk of sudden cardiac death. JAMA. 1998;279:23-28.
Mori TA, Bao DQ, Burke V., et al. Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans. Hypertension. 1999; 34:253-260.
Haalaq H., Smith TW, Leaf A. Modulation of dihydropyridinesensitive calcium channels in heart cells by fish oil fatty acids. Proc Natl Acad Sci U S A. 1992;89:1760-1764.
Harris WS, Gonzales M., Laney N., et al. Effects of ω-3 fatty acids on heart rate in cardiac transplant recipients. Am J Cardiol. 2006;98:1393-1395.
Dyer AR, Persky V., Stamler J., et al. Heart rate as a prognostic factor for coronary heart disease and mortality. Am J Epidemiol. 1980;112:736-749.
Dallongeville J., Yarnell J., Ducimetiere P., et al. Fish consumption is associated with lower heart rates. Circulation. 2003;108:820-825.
Grimsgaard S., Bonaa KH, Hansen JB, Myrhe ES Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on hemodynamics in humans. Am J Clin Nutr. 1998;68:52-59.
Howe PR Dietary fats and hypertension. Ann N Y Acad Sci. 1997;827:339-352.
Kris-Etherton Pm, Harris WS, Appel LJ Fish consumption, fish oil, ω-3 fatty acids, and cardiovascular disease. Arterioscler Thromb Vasc Biol. 2003;23:20-31.
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Article first published: September 2007
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PubMed: 17875948
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