Massive Horizontal Gene Transfer in Bdelloid Rotifers
Abstract
Horizontal gene transfer in metazoans has been documented in only a few species and is usually associated with endosymbiosis or parasitism. By contrast, in bdelloid rotifers we found many genes that appear to have originated in bacteria, fungi, and plants, concentrated in telomeric regions along with diverse mobile genetic elements. Bdelloid proximal gene-rich regions, however, appeared to lack foreign genes, thereby resembling those of model metazoan organisms. Some of the foreign genes were defective, whereas others were intact and transcribed; some of the latter contained functional spliceosomal introns. One such gene, apparently of bacterial origin, was overexpressed in Escherichia coli and yielded an active enzyme. The capture and functional assimilation of exogenous genes may represent an important force in bdelloid evolution.
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We thank W. Reznikoff, M. Belfort, and D. Mark Welch for comments and J. Mark Welch, K. van Doninck, and J. Hur for communicating results before publication. Supported by NSF grant MCB-0614142 (M.M. and I.R.A.) and NIH grant GM072708 (M.M.). Sequences obtained in this study were deposited in GenBank (accession numbers EU643473 to EU643504).
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Published In
Science
Volume 320 | Issue 5880
30 May 2008
30 May 2008
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American Association for the Advancement of Science.
Submission history
Received: 12 February 2008
Accepted: 22 April 2008
Published in print: 30 May 2008
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