Mesenchymal Stem Cells: Isolation and Therapeutics
Publication: Stem Cells and Development
Volume 13, Issue Number 4
Abstract
Mesenchymal stem cells (MSCs) are progenitors of all connective tissue cells. In adults of multiple vertebrate species, MSCs have been isolated from bone marrow (BM) and other tissues, expanded in culture, and differentiated into several tissue-forming cells such as bone, cartilage, fat, muscle, tendon, liver, kidney, heart, and even brain cells. Recent advances in the practical end of application of MSCs toward regeneration of a human-shaped articular condyle of the synovial joint is one example of their functionality and versatility. The present review not only outlines several approaches relevant to the isolation and therapeutic use of MSCs, but also presents several examples of phenotypic and functional characterization of isolated MSCs and their progeny.
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Published In
Stem Cells and Development
Volume 13 • Issue Number 4 • August 2004
Pages: 436 - 448
PubMed: 15345137
Copyright
Copyright 2004, Mary Ann Liebert, Inc.
History
Published online: 29 September 2004
Published in print: August 2004
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