Phytotherapy Research

Volume 10, Issue 3 p. 207-210

Research Article

Screening of Traditional Medicines for their Inhibitory Activity Against HIV-1 Protease

Hong-Xi Xu,

Hong-Xi Xu

Department of Chemistry, National University of Singapore, 10 Kent Ridge Cresent, Singapore 0511

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Min Wan,

Min Wan

Department of Biochemistry, National University of Singapore, 10 Kent Ridge Cresent, Singapore 0511

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Boon-Nee Loh,

Boon-Nee Loh

Department of Biochemistry, National University of Singapore, 10 Kent Ridge Cresent, Singapore 0511

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Oi-Lian Kon,

Oi-Lian Kon

Department of Biochemistry, National University of Singapore, 10 Kent Ridge Cresent, Singapore 0511

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Peng-Wai Chow,

Peng-Wai Chow

Department of Chemistry, National University of Singapore, 10 Kent Ridge Cresent, Singapore 0511

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Keng-Yeow Sim,

Corresponding Author

Keng-Yeow Sim

Department of Chemistry, National University of Singapore, 10 Kent Ridge Cresent, Singapore 0511

Department of Chemistry, National University of Singapore, 10 Kent Ridge Cresent, Singapore 0511Search for more papers by this author

Hong-Xi Xu,

Hong-Xi Xu

Department of Chemistry, National University of Singapore, 10 Kent Ridge Cresent, Singapore 0511

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Min Wan,

Min Wan

Department of Biochemistry, National University of Singapore, 10 Kent Ridge Cresent, Singapore 0511

Search for more papers by this author

Boon-Nee Loh,

Boon-Nee Loh

Department of Biochemistry, National University of Singapore, 10 Kent Ridge Cresent, Singapore 0511

Search for more papers by this author

Oi-Lian Kon,

Oi-Lian Kon

Department of Biochemistry, National University of Singapore, 10 Kent Ridge Cresent, Singapore 0511

Search for more papers by this author

Peng-Wai Chow,

Peng-Wai Chow

Department of Chemistry, National University of Singapore, 10 Kent Ridge Cresent, Singapore 0511

Search for more papers by this author

Keng-Yeow Sim,

Corresponding Author

Keng-Yeow Sim

Department of Chemistry, National University of Singapore, 10 Kent Ridge Cresent, Singapore 0511

Department of Chemistry, National University of Singapore, 10 Kent Ridge Cresent, Singapore 0511Search for more papers by this author

First published: May 1996

https://doi.org/10.1002/(SICI)1099-1573(199605)10:3<207::AID-PTR812>3.0.CO;2-U

Citations: 31

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Abstract

Aqueous extracts of 75 different traditional medicines, currently used for the treatment of various human diseases in China, Japan and Indonesia, were screened for possible inhibitory activity against HIV-1 protease using fluorogenic assay. Forty extracts exhibited inhibitory activity at a concentration of 250 μg/mL, and 18 of them inhibited HIV-1 protease activity by more than 70%. Among the extracts examined, Belamcanda chinensis, Magnolia fargesii, Paeonia suffruticosa, Phellodendron amurense and Terminalia chebula were also effective at a concentration of 25 μg/mL in the fluorogenic assay.

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Volume10, Issue3

May 1996

Pages 207-210

Screening of Traditional Medicines for their Inhibitory Activity Against HIV-1 Protease

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Screening of Traditional Medicines for their Inhibitory Activity Against HIV-1 Protease

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