Summary
In experimental dogs, the effect of APN in alleviating the ischemiareperfusion injury was prominent. Compared with the sustained ischemia group, superoxide dismutase (SOD) in the ischemic region of myocardial tissue in the ischemiareperfusion group was significantly decreased and malondialdehyde (MDA) markedly increased: Ca2+ in myocardial cells was increased; and ultrastructural changes of myocardial tissues were severe. In the APN-pretreated ischemia-reperfusion group, on the contrary, all the above parameters showed reversely, i,e., SOD increased, MDA and intracellular Ca2+ decreased, the ultrastructure changes were less distorted.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Zhao Huayue, Fang Weiyi. Antithrombotic effects of a Chinese medicina herb (Flavone from the root of andrographis Paniculata) for prevention of myocardial infarction. MMW, 1990; 132: 132
Simposon P J, Mitsos S E, Gallagher K Pet al. Prostacyclin protects ischemic reperfused myocardium in the dog by inhibition of neutrophil activation. Am Heart J, 1987; 113: 129
Marklund S. Marklund G. Involvement of the Superoxide anion radical in the autoxidaion of pyrogallol and a convenient assay for Superoxide dismutase. Eur J Biochem, 1974; 47: 469
1984, 2:8
Lowry O H, Rosebrough N J, Farr A Let al. Protein measurement with the folin phenol reagent. J Bio chem, 1951; 193: 265
1988; 3:180
Nayler W G, Elz J S. Reperfusion injury: laboratory artifact or clinical dilemma? Circulation, 1986; 74: 215
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Zhi-ling, G., Hua-yue, Z. & Xin-hua, Z. The effect of Andrographis Paniculata Nees (APN) in alleviating the myocardial ischemic reperfusion injury. Journal of Tongji Medical University 14, 49–51 (1994). https://doi.org/10.1007/BF02888059
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02888059