Elsevier

Phytomedicine

Volume 6, Issue 3, July 1999, Pages 157-161
Phytomedicine

Effect of Andrographis paniculata extract on progesterone in blood plasma of pregnant rats

https://doi.org/10.1016/S0944-7113(99)80003-8 Get rights and content

Summary

The effect of the powdered extract of Andrographis paniculata leaves (APE), an active principle of Kan Jang tablets [standardized for content of andrographolide (4.6%) and 14-deoxo-andrographolide (2.3%) content (total andrographolids — 6.9%)] on blood progesterone content in rats was studied. Peroral administration of APE during the first 19 days of pregnancy in doses of 200, 600, and 2000 mg/kg (i.e. doses 30, 90, and 300 fold higher than its daily therapeutic dose in humans) does not exhibit any effect on the elevated level of progesterone in the blood plasma of rats. Let us assume then that in therapeutic dose, Andrographis paniculata extract cannot induce progesterone-mediated termination of pregnancy.

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Address A. Panossian, Guelbenkian Research and Drug Quality Control Laboratories of the Drug Agency, 49/4 Komitas str., 375051, Armenia.

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Copyright © 1999 Urban & Fischer Verlag. Published by Elsevier GmbH All rights reserved.