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Abstract
Two new flavones, designated as andropaniculosin A (1) and andropaniculoside A (2), and 30 known compounds were isolated as a result of detailed chemical examination on the whole plants of Andrographis paniculata. Their structures have been elucidated mainly by 1D and 2D NMR, and MS spectroscopic methods. Among them, four flavonoids showed potent inhibition of collagen, arachidonic acid, thrombin, and platelet activation factor induced platelet aggregation. Furthermore, a diterpenoid demonstrated moderate vasorelaxing effect in isolated rat thoracic aorta.
Acknowledgements
The authors are grateful to the National Science Council, Taiwan (NSC 93-2113-M-006-001) for financial support for this research.
Notes
∥ Present address: Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan.