Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Andrographolide Inhibits the Production of TNF-α and Interleukin-12 in Lipopolysaccharide-Stimulated Macrophages: Role of Mitogen-Activated Protein Kinases
Lin-Hua QinLing KongGuo-Jun ShiZheng-Tao WangBao-Xue Ge
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2006 Volume 29 Issue 2 Pages 220-224

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Abstract

Andrographolide has been reported to possess a variety of pharmacological activities. In this study, we have investigated the effect of andrographolide on the production of TNF-α and IL-12 (Interleukin-12) in murine peritoneal macrophages. Andrographolide decreased TNF-α, IL-12a and IL-12b at mRNA level, and reduced the production of TNF-α and IL-12p70 proteins in a concentration-dependent manner. Furthermore, we have found that addition of andrographolide inhibited the activation of ERK1/2 MAP kinase, but not that of JNK, p38 or NF-κB. These results suggested that andrographolide inhibit LPS-induced production of TNF-α via suppression of the ERK1/2 signaling pathway.

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© 2006 The Pharmaceutical Society of Japan
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