Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
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ISSN-L : 0009-2363
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Flavonoids from Andrographis viscosula
Yerra Koteswara RaoAmooru Gangaiah DamuAlahari Janardhan RaoShanmuganathan VenkatesanPing-Chung KuoChunduri Venkata RaoTian-Shung Wu
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2003 Volume 51 Issue 12 Pages 1374-1376

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Abstract

Phytochemical investigation of the whole plant of Andrographis viscosula has led to the isolation of three new 2′-oxygenated flavonoids, (2R)-5-hydroxy-7,2′,3′-trimethoxyflavanone (1), 7,2′,5′-trimethoxyflavone (2), 5,7,2′,3′-tetramethoxyflavone (3), and eight known flavones, 5,7,2′-trimethoxyflavone (4), 5,7,2′,4′,5′-pentamethoxyflavone (5), echioidinin (6), 5,2′,6′-trihydroxy-7-methoxyflavone (7), 5-hydroxy-7,2′-dimethoxyflavone (8), echioidin (9), echioidinin 5-O-glucoside (10), and 5,2′,6′-trihydroxy-7-methoxyflavone 2′-O-glucoside (11). The structures of 1—11 were elucidated by physical and spectral methods, including extensive 2D NMR studies. The presence of 2′-oxygenated flavonoids is apparently restricted to Andrographis species in Acanthaceae. Therefore, 2′-oxygenated flavonoids are regarded as chemotaxonomic markers of Andrographis genus in the Acanthaceae family.

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© 2003 The Pharmaceutical Society of Japan
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