Abstract
Novel bis-andrographolide ether (1) and six known compounds andrographolide, 14-deoxy-11,12-didehydroandrographolide, andrograpanin, 14-deoxyandrographolide, (+/-)-5-hydroxy-7,8-dimethoxyflavanone, and 5-hydroxy-7,8-dimethoxyflavone have been isolated from the aerial parts of Andrographis paniculata and their structures were established by spectral data. All the isolates were tested for the anti-HIV and cytotoxic activity.
Publication types
- Research Support, Non-U.S. Gov't
MeSH terms
- Andrographis / chemistry*
- Antiviral Agents / isolation & purification*
- Antiviral Agents / pharmacology
- Diterpenes / isolation & purification*
- Diterpenes / pharmacology
- Ethers
- Flavones / isolation & purification*
- Flavones / pharmacology
- HIV Infections / drug therapy
- HIV-1 / drug effects
- Humans
- Microbial Sensitivity Tests
Substances
- Antiviral Agents
- Diterpenes
- Ethers
- Flavones
- andrographolide