Abstract
Andrographolide, neoandrographolide and 14-deoxy-11,12-didehydroandrographolide, ent-labdene diterpenes isolated from Andrographis paniculata showed viricidal activity against herpes simplex virus 1 (HSV-1). None of these compounds exhibited significant cytotoxicity at viricidal concentrations.
Copyright 2005 John Wiley & Sons, Ltd.
Publication types
- Research Support, Non-U.S. Gov't
MeSH terms
- Andrographis*
- Animals
- Antiviral Agents / pharmacology*
- Chlorocebus aethiops
- Diterpenes / pharmacology
- Glucosides / pharmacology
- Herpesvirus 1, Human / drug effects*
- Plant Extracts / pharmacology*
- Plant Leaves
- Tetrahydronaphthalenes / pharmacology
- Vero Cells
Substances
- Antiviral Agents
- Diterpenes
- Glucosides
- Plant Extracts
- Tetrahydronaphthalenes
- andrographolide
- neoandrographolide