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Constituents of Ardisia japonica and Their in Vitro Anti-HIV Activity

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Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli “Federico II”, via D. Montesano 49, 80131 Napoli, Italy
Centro Interdipartimentale di Chimica, Biologia e Tecnologia Farmaceutiche (C.I.C.B.T.F.), Università degli Studi di Salerno Piazza Vittorio Emanuele 9, Penta di Fisciano, Salerno, Italy
MRC Collaborative Centre, 1-3 Burtonhole Lane, Mill Hill, London NW7 1AD, U.K.
Cite this: J. Nat. Prod. 1996, 59, 6, 565–569
Publication Date (Web):June 22, 1996
https://doi.org/10.1021/np960074h
Copyright © 1996 American Chemical Society and American Society of Pharmacognosy
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    Abstract

    As part of our screening of anti-AIDS agents from medicinal plants, the MeOH extract of the aerial parts of Ardisia japonica was tested, and it showed moderate in vitro anti-HIV activity. Reexamination to identify the compounds responsible for the anti-HIV activity revealed several known compounds and a new triterpenoid saponin (4) whose structure elucidation was accomplished by 1H− 1H correlation spectroscopy (COSY, HOHAHA, ROESY) and 1H-13C heteronuclear correlation (HETCOR) NMR experiments. All of the isolated compounds were tested and, although none of the triterpenoid saponins was active, bergenin and norbergenin showed weak anti-HIV activity.

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     Abstract published in Advance ACS Abstracts, April 15, 1996.

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