Analogs of 3′-Amino-3′-Deoxyadenosine Inhibit HIV-1 Replication
Publication: AIDS Research and Human Retroviruses
Volume 5, Issue Number 6
Abstract
Several different nucleoside analogs have been demonstrated to inhibit retroviral RNA-dependent DNA polymerase activity in preference to cellular DNA-dependent DNA polymerases. 3′-Amino derivatives of 3-deoxyadenosine was analyzed for their antiviral activity toward HIV-1 and for their host cell toxicity. Puromycin aminonucleoside (PANS), PANS 5′-monophosphate, and 3′-amino-3′-deoxyadenosine triphosphate all inhibited HIV-1 replication in acutely infected cells. No significant antiviral effects of PANS were demonstrated in chronically infected cells. The effect of PANS was demonstrated at an early step in HIV-1 replication, most likely reverse transcription. 3′-Aminonucleoside analogs are a novel class of inhibitors of HIV-1 replication that require further analysis in cell culture and animal studies.
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Published In
AIDS Research and Human Retroviruses
Volume 5 • Issue Number 6 • December 1989
Pages: 647 - 653
PubMed: 2611044
History
Published online: 16 March 2009
Published in print: December 1989
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