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TRP channel activation by reversible covalent modification
Andrew Hinman, Huai-hu Chuang, Diana M. Bautista, David Julius
Proc Natl Acad Sci U S A. 2006 Dec 19; 103(51): 19564–19568. Published online 2006 Dec 12. doi: 10.1073/pnas.0609598103
PMCID:
PMC1748265
Article PDF–893K

Is Cited by the Following 400 Articles in this Archive:

CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint pain and inflammation in experimental gouty arthritis
Chengyu Yin, Boyu Liu, Zishan Dong, Sai Shi, Chenxing Peng, Yushuang Pan, Xiaochen Bi, Huimin Nie, Yunwen Zhang, Yan Tai, Qimiao Hu, Xuan Wang, Xiaomei Shao, Hailong An, Jianqiao Fang, Chuan Wang, Boyi Liu
Nat Commun. 2024; 15: 3263. Published online 2024 Apr 16. doi: 10.1038/s41467-024-47640-7
PMCID:
PMC11021482
Article PDF–9.3M
Targeting TRP channels: recent advances in structure, ligand binding, and molecular mechanisms
Jian Huang, Aron Korsunsky, Mahdieh Yazdani, Jianhan Chen
Front Mol Neurosci. 2023; 16: 1334370. Published online 2024 Jan 11. doi: 10.3389/fnmol.2023.1334370
PMCID:
PMC10808746
Article PDF–5.3M
Avoidance of thiazoline compound depends on multiple sensory pathways mediated by TrpA1 and ORs in Drosophila
Shoma Sato, Aliyu Mudassir Magaji, Makoto Tominaga, Takaaki Sokabe
Front Mol Neurosci. 2023; 16: 1249715. Published online 2023 Dec 22. doi: 10.3389/fnmol.2023.1249715
PMCID:
PMC10771277
Article PDF–6.6M
A Novel Flp Reporter Mouse Shows That TRPA1 Expression Is Largely Limited to Sensory Neuron Subsets
Mayur J. Patil, Seol-Hee Kim, Parmvir K. Bahia, Sanjay S. Nair, Teresa S. Darcey, Jailene Fiallo, Xiao Xia Zhu, Robert D. Frisina, Stephen H. Hadley, Thomas E. Taylor-Clark
eNeuro. 2023 Dec; 10(12): ENEURO.0350-23.2023. Prepublished online 2023 Nov 21. Published online 2023 Dec 4. doi: 10.1523/ENEURO.0350-23.2023
PMCID:
PMC10698635
Article PDF–5.5M
Allyl Isothiocyanate Maintains DHA-Containing Glycerophospholipids and Ameliorates the Cognitive Function Decline in OVX Mice
Akika Nagata, Shiori Oishi, Nanako Kirishita, Keita Onoda, Takuma Kobayashi, Yuko Terada, Akira Minami, Nanami Senoo, Yasukiyo Yoshioka, Kunitoshi Uchida, Keisuke Ito, Shinji Miura, Noriyuki Miyoshi
ACS Omega. 2023 Nov 14; 8(45): 43118–43129. Published online 2023 Nov 1. doi: 10.1021/acsomega.3c06622
PMCID:
PMC10652735
Article PDF–6.6M
Development of covalent chemogenetic K2P channel activators
Parker E. Deal, Haerim Lee, Abhisek Mondal, Marco Lolicato, Philipe Ribeiro Furtado de Mendonca, Holly Black, Xochina El-Hilali, Clifford Bryant, Ehud Y. Isacoff, Adam R. Renslo, Daniel L. Minor, Jr.
Version 1. bioRxiv. Preprint. 2023 Oct 18. doi: 10.1101/2023.10.15.561774
PMCID:
PMC10614804
Article PDF–4.4M
Temperature activated transient receptor potential ion channels from Antarctic fishes
Julia M. York
Open Biol. 2023 Oct; 13(10): 230215. Published online October 18, 2023. doi: 10.1098/rsob.230215
PMCID:
PMC10581778
Article PDF–1.6M
Canine, mouse, and human transient receptor potential ankyrin 1 (TRPA1) channels show different sensitivity to menthol or cold stimulation
Takuya YAMAGUCHI, Kunitoshi UCHIDA, Jun YAMAZAKI
J Vet Med Sci. 2023 Dec; 85(12): 1301–1309. Published online 2023 Oct 11. doi: 10.1292/jvms.23-0327
PMCID:
PMC10788164
Article PDF–2.7M
TRPA1-dependent and -independent activation by commonly used preservatives
Maximilian L. Mager, Cosmin I. Ciotu, Markus Gold-Binder, Stefan Heber, Michael J. M. Fischer
Front Pharmacol. 2023; 14: 1248558. Published online 2023 Oct 4. doi: 10.3389/fphar.2023.1248558
PMCID:
PMC10582264
Article PDF–2.0M
Transient Receptor Potential Ankyrin 1 (TRPA1) Channel Mediates Acrolein Cytotoxicity in Human Lung Cancer Cells
Akihiko Sakamoto, Yusuke Terui, Kazuei Igarashi, Keiko Kashiwagi
Int J Mol Sci. 2023 Jul; 24(14): 11847. Published online 2023 Jul 24. doi: 10.3390/ijms241411847
PMCID:
PMC10380761
Article PDF–1.7M
TRPA1 activation in non-sensory supporting cells contributes to regulation of cochlear sensitivity after acoustic trauma
A. Catalina Vélez-Ortega, Ruben Stepanyan, Stephanie E. Edelmann, Sara Torres-Gallego, Channy Park, Desislava A. Marinkova, Joshua S. Nowacki, Ghanshyam P. Sinha, Gregory I. Frolenkov
Nat Commun. 2023; 14: 3871. Published online 2023 Jun 30. doi: 10.1038/s41467-023-39589-w
PMCID:
PMC10313773
Article PDF–9.3M
Elucidation of the binding mode of organic polysulfides on the human TRPA1 receptor
Balázs Nemes, Szabolcs László, Balázs Zoltán Zsidó, Csaba Hetényi, Adam Feher, Ferenc Papp, Zoltan Varga, Éva Szőke, Zoltán Sándor, Erika Pintér
Front Physiol. 2023; 14: 1180896. Published online 2023 Jun 7. doi: 10.3389/fphys.2023.1180896
PMCID:
PMC10282659
Article PDF–2.5M
Molecular Dynamic Simulations Reveal the Activation Mechanisms of Oxidation-Induced TRPV1
Yanyan Chu, Huanhuan Zhang, Mengke Yang, Rilei Yu
Int J Mol Sci. 2023 Jun; 24(11): 9553. Published online 2023 May 31. doi: 10.3390/ijms24119553
PMCID:
PMC10253787
Article PDF–3.2M
Intraganglionic reactive oxygen species mediate inflammatory pain and hyperalgesia through TRPA1 in the rat
Youping Zhang, Jamila Asgar, Huizhong Shou, Joshua Pak, Joyce Teixeira Da Silva, Jin Y. Ro
Front Pain Res (Lausanne) 2023; 4: 1204057. Published online 2023 May 30. doi: 10.3389/fpain.2023.1204057
PMCID:
PMC10261988
Article PDF–1.7M
Molecular mechanism of hyperactivation conferred by a truncation of TRPA1
Avnika Bali, Samantha P. Schaefer, Isabelle Trier, Alice L. Zhang, Lilian Kabeche, Candice E. Paulsen
Nat Commun. 2023; 14: 2867. Published online 2023 May 19. doi: 10.1038/s41467-023-38542-1
PMCID:
PMC10199097
Article PDF–3.7M
Transient Receptor Potential Ankyrin 1 (TRPA1) Channel as a Sensor of Oxidative Stress in Cancer Cells
Francesco Moccia, Daniela Montagna
Cells. 2023 May; 12(9): 1261. Published online 2023 Apr 26. doi: 10.3390/cells12091261
PMCID:
PMC10177399
Article PDF–1.9M
Molecular architecture and gating mechanisms of the Drosophila TRPA1 channel
Xiaofei Wang, Yawen Li, Hong Wei, Zhisen Yang, Rui Luo, Yongxiang Gao, Wei Zhang, Xin Liu, Linfeng Sun
Cell Discov. 2023; 9: 36. Published online 2023 Apr 4. doi: 10.1038/s41421-023-00527-1
PMCID:
PMC10073219
Article PDF–3.4M
Transient receptor potential Ankyrin‐1 (TRPA1) agonists suppress myelination and induce demyelination in organotypic cortical slices
Vincenzo Giacco, Grace Flower, Maria Artamonova, Jake Hunter, Aitana Padilla Requerey, Nicola B. Hamilton
Glia. 2023 Jun; 71(6): 1402–1413. Published online 2023 Feb 10. doi: 10.1002/glia.24347
PMCID:
PMC10953362
Article PDF–6.7M
Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1β induced hypothermia and reflex anti-inflammatory responses
Harold A. Silverman, Aisling Tynan, Tyler D. Hepler, Eric H. Chang, Manojkumar Gunasekaran, Jian Hua Li, Tomás S. Huerta, Tea Tsaava, Qing Chang, Meghan E. Addorisio, Adrian C. Chen, Dane A. Thompson, Valentin A. Pavlov, Michael Brines, Kevin J. Tracey, Sangeeta S. Chavan
Mol Med. 2023; 29: 4. Published online 2023 Jan 18. doi: 10.1186/s10020-022-00590-6
PMCID:
PMC9847185
Article PDF–2.4M
Bipartite Activation of Sensory Neurons by a TRPA1 Agonist Allyl Isothiocyanate Is Reflected by Complex Ca2+ Influx and CGRP Release Patterns: Enhancement by NGF and Inhibition with VAMP and SNAP-25 Cleaving Botulinum Neurotoxins
Mariia Belinskaia, Jiafu Wang, Seshu Kumar Kaza, Caren Antoniazzi, Tomas Zurawski, J. Oliver Dolly, Gary W. Lawrence
Int J Mol Sci. 2023 Jan; 24(2): 1338. Published online 2023 Jan 10. doi: 10.3390/ijms24021338
PMCID:
PMC9865456
Article PDF–3.9M
Biochemical and Structural Insights into FIH‐Catalysed Hydroxylation of Transient Receptor Potential Ankyrin Repeat Domains
Benjamin G. Saward, Thomas M. Leissing, Ian J. Clifton, Anthony Tumber, Christopher M. Timperley, Richard J. Hopkinson, Prof. Christopher J. Schofield
Chembiochem. 2023 Feb 14; 24(4): e202200576. Published online 2023 Jan 9. doi: 10.1002/cbic.202200576
PMCID:
PMC10946520
Article PDF–1.9M
Ion channel regulation of gut immunity
Jing Feng, Zili Xie, Hongzhen Hu
J Gen Physiol. 2023 Feb 6; 155(2): e202113042. Published online 2022 Dec 2. doi: 10.1085/jgp.202113042
PMCID:
PMC9723512
Article PDF–2.2M
Potent Activation of Human but Not Mouse TRPA1 by JT010
Masaki Matsubara, Yukiko Muraki, Noriyuki Hatano, Hiroka Suzuki, Katsuhiko Muraki
Int J Mol Sci. 2022 Nov; 23(22): 14297. Published online 2022 Nov 18. doi: 10.3390/ijms232214297
PMCID:
PMC9695908
Article PDF–2.5M
Isolation of human TRPA1 channel from transfected HEK293 cells and identification of alkylation sites after sulfur mustard exposure
Katharina Müller-Dott, Horst Thiermann, Harald John, Dirk Steinritz
Arch Toxicol. 2023; 97(2): 429–439. Published online 2022 Nov 12. doi: 10.1007/s00204-022-03411-1
PMCID:
PMC9859856
Article PDF–1.3M
Function and therapeutic potential of transient receptor potential ankyrin 1 in fibrosis
Yicheng Wei, Jialuo Cai, Ruiqiu Zhu, Ke Xu, Hongchang Li, Jianxin Li
Front Pharmacol. 2022; 13: 1014041. Published online 2022 Oct 6. doi: 10.3389/fphar.2022.1014041
PMCID:
PMC9582847
Article PDF–1.2M
Drimane Sesquiterpene Aldehydes Control Candida Yeast Isolated from Candidemia in Chilean Patients
Víctor Marín, Bryan Bart, Nicole Cortez, Verónica A. Jiménez, Víctor Silva, Oscar Leyton, Jaime R. Cabrera-Pardo, Bernd Schmidt, Matthias Heydenreich, Viviana Burgos, Cristian Paz
Int J Mol Sci. 2022 Oct; 23(19): 11753. Published online 2022 Oct 4. doi: 10.3390/ijms231911753
PMCID:
PMC9570005
Article PDF–1.5M
Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain
Chirag Vasavda, Risheng Xu, Jason Liew, Ruchita Kothari, Ryan S. Dhindsa, Evan R. Semenza, Bindu D. Paul, Dustin P. Green, Mark F. Sabbagh, Joseph Y. Shin, Wuyang Yang, Adele M. Snowman, Lauren K. Albacarys, Abhay Moghekar, Carlos A. Pardo-Villamizar, Mark Luciano, Judy Huang, Chetan Bettegowda, Shawn G. Kwatra, Xinzhong Dong, Michael Lim, Solomon H. Snyder
Sci Adv. 2022 Aug; 8(31): eabo5633. Published online 2022 Aug 3. doi: 10.1126/sciadv.abo5633
PMCID:
PMC9348805
Article PDF–6.8M
Protease-activated receptors in health and disease
Chloe J. Peach, Laura E. Edgington-Mitchell, Nigel W. Bunnett, Brian L. Schmidt
Physiol Rev. 2023 Jan 1; 103(1): 717–785. Published online 2022 Jul 28. doi: 10.1152/physrev.00044.2021
PMCID:
PMC9662810
Article
Analysis of Structural Determinants of Peptide MS 9a-1 Essential for Potentiating of TRPA1 Channel
Yulia A. Logashina, Kseniya I. Lubova, Ekaterina E. Maleeva, Viktor A. Palikov, Yulia A. Palikova, Igor A. Dyachenko, Yaroslav A. Andreev
Mar Drugs. 2022 Jul; 20(7): 465. Published online 2022 Jul 21. doi: 10.3390/md20070465
PMCID:
PMC9320628
Article PDF–1.1M
Estrogen metabolites increase nociceptor hyperactivity in a mouse model of uterine pain
Zili Xie, Jing Feng, Tao Cai, Ronald McCarthy, Mark D. Eschbach, II, Yuhui Wang, Yonghui Zhao, Zhihua Yi, Kaikai Zang, Yi Yuan, Xueming Hu, Fengxian Li, Qin Liu, Aditi Das, Sarah K. England, Hongzhen Hu
JCI Insight. 2022 May 23; 7(10): e149107. Published online 2022 May 23. doi: 10.1172/jci.insight.149107
PMCID:
PMC9220826
Article PDF–6.6M