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Superparamagnetic Iron Oxide Nanoparticles: Promises for Diagnosis and Treatment of Multiple Sclerosis

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National Cell Bank, Pasteur Institute of Iran, Tehran, 11365-8639, Iran
Department of Neurology
§ Sina MS Research Center
Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
Department of General, Organic, and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, Avenue Maistriau, 19, B-7000 Mons, Belgium
*E-mail: [email protected]. Website: www.biospion.com.
Cite this: ACS Chem. Neurosci. 2011, 2, 3, 118–140
Publication Date (Web):February 4, 2011
https://doi.org/10.1021/cn100100e
Copyright © 2011 American Chemical Society

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    Abstract

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    Smart superparamagnetic iron oxide nanoparticles (SPIONs) are the most promising candidate for theragnosis (i.e., diagnosis and treatment) of multiple sclerosis. A deep understanding of the dynamics of the in vivo neuropathology of multiple sclerosis can be achieved by improving the efficiency of various medical techniques (e.g., positron emission tomography and magnetic resonance imaging) using multimodal SPIONs. In this Review, recent advances and challenges in the development of smart SPIONs for theragnostic applications are comprehensively described. In addition, critical outlines of emerging developments are provided from the points of view of both clinicians and nanotechnologists.

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