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Graphene Can Wreak Havoc with Cell Membranes

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† Dipartimento di Chimica “G. Ciamician”, Alma Mater Studiorum—Università di Bologna, via F. Selmi 2, 40126 Bologna, Italy
‡ Departamento de Informática, Centro de Ciências e Tecnologias da Computação, Universidade do Minho, 4710-057 Braga, Portugal
*(M.C.) E-mail: [email protected]
*(F.Z.) E-mail: [email protected]
Cite this: ACS Appl. Mater. Interfaces 2015, 7, 7, 4406–4414
Publication Date (Web):February 4, 2015
https://doi.org/10.1021/am508938u
Copyright © 2015 American Chemical Society
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    Abstract

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    Molecular dynamics—coarse grained to the level of hydrophobic and hydrophilic interactions—shows that small hydrophobic graphene sheets pierce through the phospholipid membrane and navigate the double layer, intermediate size sheets pierce the membrane only if a suitable geometric orientation is met, and larger sheets lie mainly flat on the top of the bilayer where they wreak havoc with the membrane and create a patch of upturned phospholipids. The effect arises in order to maximize the interaction between hydrophobic moieties and is quantitatively explained in terms of flip-flops by the analysis of the simulations. Possible severe biological consequences are discussed.

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    16. Vikram Reddy Ardham and Frédéric Leroy . Atomistic and Coarse-Grained Modeling of the Adsorption of Graphene Nanoflakes at the Oil–Water Interface. The Journal of Physical Chemistry B 2018, 122 (8) , 2396-2407. https://doi.org/10.1021/acs.jpcb.7b11173
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    20. Chong Cheng, Shuang Li, Arne Thomas, Nicholas A. Kotov, and Rainer Haag . Functional Graphene Nanomaterials Based Architectures: Biointeractions, Fabrications, and Emerging Biological Applications. Chemical Reviews 2017, 117 (3) , 1826-1914. https://doi.org/10.1021/acs.chemrev.6b00520
    21. Mattia Bramini, Silvio Sacchetti, Andrea Armirotti, Anna Rocchi, Ester Vázquez, Verónica León Castellanos, Tiziano Bandiera, Fabrizia Cesca, and Fabio Benfenati . Graphene Oxide Nanosheets Disrupt Lipid Composition, Ca2+ Homeostasis, and Synaptic Transmission in Primary Cortical Neurons. ACS Nano 2016, 10 (7) , 7154-7171. https://doi.org/10.1021/acsnano.6b03438
    22. Xuefeng Zou, Li Zhang, Zhaojun Wang, and Yang Luo . Mechanisms of the Antimicrobial Activities of Graphene Materials. Journal of the American Chemical Society 2016, 138 (7) , 2064-2077. https://doi.org/10.1021/jacs.5b11411
    23. Vy T. H. Pham, Vi Khanh Truong, Matthew D. J. Quinn, Shannon M. Notley, Yachong Guo, Vladimir A. Baulin, Mohammad Al Kobaisi, Russell J. Crawford, and Elena P. Ivanova . Graphene Induces Formation of Pores That Kill Spherical and Rod-Shaped Bacteria. ACS Nano 2015, 9 (8) , 8458-8467. https://doi.org/10.1021/acsnano.5b03368
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    28. Yanhao Hou, Weiguang Wang, Paulo Bartolo. The effect of graphene and graphene oxide induced reactive oxygen species on polycaprolactone scaffolds for bone cancer applications. Materials Today Bio 2024, 24 , 100886. https://doi.org/10.1016/j.mtbio.2023.100886
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    49. Shounak Roy, Sanchita Sarkhel, Deepali Bisht, Samerender Nagam Hanumantharao, Smitha Rao, Amit Jaiswal. Antimicrobial mechanisms of biomaterials: from macro to nano. Biomaterials Science 2022, 10 (16) , 4392-4423. https://doi.org/10.1039/D2BM00472K
    50. Zhen Li, Xiaohong Zhu, Jiawei Li, Jie Zhong, Jun Zhang, Jun Fan. Molecular insights into the resistance of phospholipid heads to the membrane penetration of graphene nanosheets. Nanoscale 2022, 14 (14) , 5384-5391. https://doi.org/10.1039/D1NR07684A
    51. Bingqing Jia, Xuancheng Du, Weijie Wang, Yuanyuan Qu, Xiangdong Liu, Mingwen Zhao, Weifeng Li, Yong‐Qiang Li. Nanophysical Antimicrobial Strategies: A Rational Deployment of Nanomaterials and Physical Stimulations in Combating Bacterial Infections. Advanced Science 2022, 9 (10) https://doi.org/10.1002/advs.202105252
    52. Vasiliki I. Syngouna, Kleanthi I. Kourtaki, Maria P. Georgopoulou, Constantinos V. Chrysikopoulos. The role of nanoparticles (titanium dioxide, graphene oxide) on the inactivation of co-existing bacteria in the presence and absence of quartz sand. Environmental Science and Pollution Research 2022, 29 (13) , 19199-19211. https://doi.org/10.1007/s11356-021-17086-1
    53. E Filipov, L Angelova, D Aceti, V Marinova, D Karashanova, A Trifonov, I Buchvarov, A Daskalova. Altering the surface morphology and wettability of chitosan/graphene coatings by femtosecond and nanosecond laser processing. Journal of Physics: Conference Series 2022, 2240 (1) , 012041. https://doi.org/10.1088/1742-6596/2240/1/012041
    54. Zonglin Gu, Guanhua Xie, Jose Manuel Perez-Aguilar. Fluorinated graphene nanomaterial causes potential mechanical perturbations to a biomembrane. Journal of Molecular Modeling 2022, 28 (2) https://doi.org/10.1007/s00894-022-05040-y
    55. Parijat Ray, Tushar Lodha, Arunangshu Biswas, Tapan K. Sau, Ch. Venkata Ramana. Particle specific physical and chemical effects on antibacterial activities: A comparative study involving gold nanostars, nanorods and nanospheres. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2022, 634 , 127915. https://doi.org/10.1016/j.colsurfa.2021.127915
    56. Yun Hao Feng, Bo Zhi Chen, Wen Min Fei, Yong Cui, Can Yang Zhang, Xin Dong Guo. Mechanism studies on the cellular internalization of nanoparticles using computer simulations: A review. AIChE Journal 2022, 68 (2) https://doi.org/10.1002/aic.17507
    57. Z. L. Shaw, Sruthi Kuriakose, Samuel Cheeseman, Michael D. Dickey, Jan Genzer, Andrew J. Christofferson, Russell J. Crawford, Chris F. McConville, James Chapman, Vi Khanh Truong, Aaron Elbourne, Sumeet Walia. Antipathogenic properties and applications of low-dimensional materials. Nature Communications 2021, 12 (1) https://doi.org/10.1038/s41467-021-23278-7
    58. Yanyan Chen, Santosh Pandit, Shadi Rahimi, Ivan Mijakovic. Interactions Between Graphene‐Based Materials and Biological Surfaces: A Review of Underlying Molecular Mechanisms. Advanced Materials Interfaces 2021, 8 (24) https://doi.org/10.1002/admi.202101132
    59. Soumalya Chakraborty, Jaydeep H. Chormale, Arvind K. Bansal. Deep eutectic systems: An overview of fundamental aspects, current understanding and drug delivery applications. International Journal of Pharmaceutics 2021, 610 , 121203. https://doi.org/10.1016/j.ijpharm.2021.121203
    60. Fika Fauzi, Muhammad Miqdam Musawwa, Habibi Hidayat, Ahmad Kusumaatmaja, Wipsar Sunu Brams Dwandaru. Nanocomposites based on biocompatible polymers and graphene oxide for antibacterial coatings. Polymers and Polymer Composites 2021, 29 (9_suppl) , S1609-S1620. https://doi.org/10.1177/09673911211020601
    61. Ana M. Díez-Pascual. State of the Art in the Antibacterial and Antiviral Applications of Carbon-Based Polymeric Nanocomposites. International Journal of Molecular Sciences 2021, 22 (19) , 10511. https://doi.org/10.3390/ijms221910511
    62. Srinivasarao Yaragalla, Karanath Balendran Bhavitha, Athanassia Athanassiou. A Review on Graphene Based Materials and Their Antimicrobial Properties. Coatings 2021, 11 (10) , 1197. https://doi.org/10.3390/coatings11101197
    63. Nabira Fatima, Umair Yaqub Qazi, Asim Mansha, Ijaz Ahmad Bhatti, Rahat Javaid, Qamar Abbas, Nimra Nadeem, Zulfiqar Ahmad Rehan, Saima Noreen, Muhammad Zahid. Recent developments for antimicrobial applications of graphene-based polymeric composites: A review. Journal of Industrial and Engineering Chemistry 2021, 100 , 40-58. https://doi.org/10.1016/j.jiec.2021.04.050
    64. Ana M. Díez-Pascual, José A. Luceño-Sánchez. Antibacterial Activity of Polymer Nanocomposites Incorporating Graphene and Its Derivatives: A State of Art. Polymers 2021, 13 (13) , 2105. https://doi.org/10.3390/polym13132105
    65. Honghai Li, Xin Chen, Weipeng Lu, Jie Wang, Yisheng Xu, Yanchuan Guo. Application of Electrospinning in Antibacterial Field. Nanomaterials 2021, 11 (7) , 1822. https://doi.org/10.3390/nano11071822
    66. Xinyue Kong, Xiangmei Liu, Yufeng Zheng, Paul K. Chu, Yu Zhang, Shuilin Wu. Graphitic carbon nitride-based materials for photocatalytic antibacterial application. Materials Science and Engineering: R: Reports 2021, 145 , 100610. https://doi.org/10.1016/j.mser.2021.100610
    67. Çağıl Kaderoğlu, Amir Nasser Shamkhali, Fatemeh Safdari, Marjan Abedi, Şinasi Ellialtıoğlu. Mechanism of transition metal interaction with graphene sheet reflected in its plasmonic excitations: Effect of gas adsorption phenomena studied by a combination of solid state and molecular orbital approaches. Applied Surface Science 2021, 554 , 149585. https://doi.org/10.1016/j.apsusc.2021.149585
    68. Najmul Haque Barbhuiya, Swatantra P. Singh, Arik Makovitzki, Pradnya Narkhede, Ziv Oren, Yaakov Adar, Edith Lupu, Lilach Cherry, Arik Monash, Christopher J. Arnusch. Virus Inactivation in Water Using Laser-Induced Graphene Filters. Materials 2021, 14 (12) , 3179. https://doi.org/10.3390/ma14123179
    69. Th.Babita Devi, M. Ahmaruzzaman. Facile synthesis of rGO/Ag@AgCl core-shells nanocomposite and their multifunctional efficacy as a photocatalyst and antimicrobial agent for decontamination of water. Journal of Alloys and Compounds 2021, 860 , 157988. https://doi.org/10.1016/j.jallcom.2020.157988
    70. Anthony J. Slate, Nathalie Karaky, Grace S. Crowther, Jonathan A. Butler, Craig E. Banks, Andrew J. McBain, Kathryn A. Whitehead. Graphene Matrices as Carriers for Metal Ions against Antibiotic Susceptible and Resistant Bacterial Pathogens. Coatings 2021, 11 (3) , 352. https://doi.org/10.3390/coatings11030352
    71. Asanah Radhi, Dasmawati Mohamad, Fatimah Suhaily Abdul Rahman, Abdul Manaf Abdullah, Habsah Hasan. Mechanism and factors influence of graphene-based nanomaterials antimicrobial activities and application in dentistry. Journal of Materials Research and Technology 2021, 11 , 1290-1307. https://doi.org/10.1016/j.jmrt.2021.01.093
    72. Lijun Liang, Xiangming Peng, Fangfang Sun, Zhe Kong, Jia-Wei Shen. A review on the cytotoxicity of graphene quantum dots: from experiment to simulation. Nanoscale Advances 2021, 3 (4) , 904-917. https://doi.org/10.1039/D0NA00904K
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    75. Mitali Mishra, Shashank Patole, Harapriya Mohapatra. Nanoparticles: Powerful Tool to Mitigate Antibiotic Resistance. 2021, 171-204. https://doi.org/10.1007/978-3-030-58259-3_6
    76. Xiaohong Zhu, Changxiong Huang, Na Li, Xinyao Ma, Zhen Li, Jun Fan. Distinct Roles of Graphene and Graphene Oxide Nanosheets in Regulating Phospholipid Flip-Flopcover Letter. SSRN Electronic Journal 2021, 42 https://doi.org/10.2139/ssrn.3951685
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    78. Tian Zhang, Pier-Luc Tremblay. Graphene: An Antibacterial Agent or a Promoter of Bacterial Proliferation?. iScience 2020, 23 (12) , 101787. https://doi.org/10.1016/j.isci.2020.101787
    79. Yang Liu, Yanmei Yang, Yuanyuan Qu, Yong-Qiang Li, Mingwen Zhao, Weifeng Li. Mild lipid extraction and anisotropic cell membrane penetration of α-phase phosphorene carbide nanoribbons by molecular dynamics simulation studies. Physical Chemistry Chemical Physics 2020, 22 (40) , 23268-23275. https://doi.org/10.1039/D0CP04145A
    80. Mahdieh Chegeni, Zahra Shokri Rozbahani, Motaleb Ghasemian, Mozhgan Mehri. Synthesis and application of the calcium alginate/SWCNT-Gl as a bio-nanocomposite for the curcumin delivery. International Journal of Biological Macromolecules 2020, 156 , 504-513. https://doi.org/10.1016/j.ijbiomac.2020.04.068
    81. Thi Truong, Selvaraj Kumar, Yu-Tzu Huang, Dave Chen, Yu-Kuo Liu, Shingjiang Lue. Size-Dependent Antibacterial Activity of Silver Nanoparticle-Loaded Graphene Oxide Nanosheets. Nanomaterials 2020, 10 (6) , 1207. https://doi.org/10.3390/nano10061207
    82. Kun Yang, Jinghuan Tian, Wei Qu, Bo Luan, Ke Liu, Jun Liu, Likui Wang, Junhui Ji, Wei Zhang. Host-mediated biofilm forming promotes post-graphene pathogen expansion via graphene micron-sheet. Frontiers of Materials Science 2020, 14 (2) , 221-231. https://doi.org/10.1007/s11706-020-0498-4
    83. Hiba Mohammed, Ajay Kumar, Elena Bekyarova, Yas Al-Hadeethi, Xixiang Zhang, Mingguang Chen, Mohammad Shahnawaze Ansari, Andrea Cochis, Lia Rimondini. Antimicrobial Mechanisms and Effectiveness of Graphene and Graphene-Functionalized Biomaterials. A Scope Review. Frontiers in Bioengineering and Biotechnology 2020, 8 https://doi.org/10.3389/fbioe.2020.00465
    84. Ana María Díez-Pascual. Antibacterial Action of Nanoparticle Loaded Nanocomposites Based on Graphene and Its Derivatives: A Mini-Review. International Journal of Molecular Sciences 2020, 21 (10) , 3563. https://doi.org/10.3390/ijms21103563
    85. Mohamed Amine Gacem, Hiba Gacem, Aminata Ould-El-Hadj-Khelil. Nanocarbons: Antibacterial, antifungal, and antiviral activity and the underlying mechanism. 2020, 505-533. https://doi.org/10.1016/B978-0-12-819786-8.00022-0
    86. Shirong Qiang, Mingyuan Wang, Jianjun Liang, Xiaolan Zhao, Qiaohui Fan, Rongyue Geng, Dongxia Luo, Zhengbin Li, Li Zhang. Effects of morphology regulated by Pb2+ on graphene oxide cytotoxicity: Spectroscopic and in vitro investigations. Materials Chemistry and Physics 2020, 239 , 122016. https://doi.org/10.1016/j.matchemphys.2019.122016
    87. Daniela Plachá, Josef Jampilek. Graphenic Materials for Biomedical Applications. Nanomaterials 2019, 9 (12) , 1758. https://doi.org/10.3390/nano9121758
    88. Qi Xin, Hameed Shah, Asmat Nawaz, Wenjing Xie, Muhammad Zain Akram, Aisha Batool, Liangqiu Tian, Saad Ullah Jan, Rajender Boddula, Beidou Guo, Qian Liu, Jian Ru Gong. Antibacterial Carbon‐Based Nanomaterials. Advanced Materials 2019, 31 (45) https://doi.org/10.1002/adma.201804838
    89. M Hatami, , H Naghdi Badi, , M Ghorbanpour, . Nano-Elicitation of Secondary Pharmaceutical Metabolites in Plant Cells: A Review. Journal of Medicinal Plants 2019, 3 (71) , 6-36. https://doi.org/10.29252/jmp.3.71.6
    90. Meng-Ying Xia, Yu Xie, Chen-Hao Yu, Ge-Yun Chen, Yuan-Hong Li, Ting Zhang, Qiang Peng. Graphene-based nanomaterials: the promising active agents for antibiotics-independent antibacterial applications. Journal of Controlled Release 2019, 307 , 16-31. https://doi.org/10.1016/j.jconrel.2019.06.011
    91. Zhaojian Qin, Tianyu Du, Youkun Zheng, Peng Luo, Jialei Zhang, Mengyang Xie, Ying Zhang, Ying Du, Lihong Yin, Daxiang Cui, Qiangbing Lu, Minghui Lu, Xuemei Wang, Hui Jiang. Glutathione Induced Transformation of Partially Hollow Gold–Silver Nanocages for Cancer Diagnosis and Photothermal Therapy. Small 2019, 15 (35) https://doi.org/10.1002/smll.201902755
    92. QianChun Wang, XiaoBo Zhai, Michael Crowe, Lu Gou, YinFeng Li, DeChang Li, Lei Zhang, JiaJie Diao, BaoHua Ji. Heterogeneous oxidization of graphene nanosheets damages membrane. Science China Physics, Mechanics & Astronomy 2019, 62 (6) https://doi.org/10.1007/s11433-018-9317-7
    93. Vishal Dutta, Pardeep Singh, Pooja Shandilya, Sheetal Sharma, Pankaj Raizada, Adesh K. Saini, Vinod Kumar Gupta, Ahmad Hosseini-Bandegharaei, Shipli Agarwal, Abolfazl Rahmani-Sani. Review on advances in photocatalytic water disinfection utilizing graphene and graphene derivatives-based nanocomposites. Journal of Environmental Chemical Engineering 2019, 7 (3) , 103132. https://doi.org/10.1016/j.jece.2019.103132
    94. Anu N. Mohan, B. Manoj. Surface modified graphene/SnO2 nanocomposite from carbon black as an efficient disinfectant against Pseudomonas aeruginosa. Materials Chemistry and Physics 2019, 232 , 137-144. https://doi.org/10.1016/j.matchemphys.2019.04.074
    95. Liang Wang, Ziwen Yuan, H. Enis Karahan, Yilei Wang, Xiao Sui, Fei Liu, Yuan Chen. Nanocarbon materials in water disinfection: state-of-the-art and future directions. Nanoscale 2019, 11 (20) , 9819-9839. https://doi.org/10.1039/C9NR02007A
    96. Bhushan Dharmadhikari, Qi Wu, Debika Debnath, Prabir Patra. Interaction of Graphene And Polycaprolactone at Atomic Level. 2019, 1-6. https://doi.org/10.1109/LISAT.2019.8816824
    97. Xuemei Lu, Jiaojiao Liu, Lu Gou, Jingliang Li, Bing Yuan, Kai Yang, Yuqiang Ma. Designing Melittin‐Graphene Hybrid Complexes for Enhanced Antibacterial Activity. Advanced Healthcare Materials 2019, 8 (9) https://doi.org/10.1002/adhm.201801521
    98. Na Lu, Liqian Wang, Min Lv, Zisheng Tang, Chunhai Fan. Graphene-based nanomaterials in biosystems. Nano Research 2019, 12 (2) , 247-264. https://doi.org/10.1007/s12274-018-2209-3
    99. Mohamad Hamdi Zainal-Abidin, Maan Hayyan, Gek Cheng Ngoh, Won Fen Wong. From nanoengineering to nanomedicine: A facile route to enhance biocompatibility of graphene as a potential nano-carrier for targeted drug delivery using natural deep eutectic solvents. Chemical Engineering Science 2019, 195 , 95-106. https://doi.org/10.1016/j.ces.2018.11.013
    100. Bo Liu, Kun Zhou. Recent progress on graphene-analogous 2D nanomaterials: Properties, modeling and applications. Progress in Materials Science 2019, 100 , 99-169. https://doi.org/10.1016/j.pmatsci.2018.09.004
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