An autopsy case report of fulminant myocarditis: Following mRNA COVID-19 vaccination

Naoki Hoshino; Masanobu Yanase; Taisuke Ichiyasu; Kazuhiko Kuwahara; Hideki Kawai; Takashi Muramatsu; Hideki Ishii; Tetsuya Tsukamoto; Shin-Ichiro Morimoto; Hideo Izawa

doi:10.1016/j.jccase.2022.06.006

An autopsy case report of fulminant myocarditis: Following mRNA COVID-19 vaccination

J Cardiol Cases. 2022 Dec;26(6):391-394. doi: 10.1016/j.jccase.2022.06.006. Epub 2022 Jul 4.

Affiliations

¹ Department of Cardiology, Fujita Health University School of Medicine, Toyoake, Japan.
² Department of Diagnostic Pathology, Fujita Health University School of Medicine, Toyoake, Japan.
³ Department of Cardiology, Fujita Health University Bantane Hospital, Nagoya, Japan.
⁴ Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Japan.

Abstract

There have been few case reports on fatal outcomes in patients with acute myocarditis after mRNA coronavirus disease 2019 (COVID-19) vaccination. In most cases of myocarditis after mRNA COVID-19 vaccination, the myocarditis is mild, and the prognosis is good. Here we report an autopsy case of fulminant myocarditis following mRNA COVID-19 vaccination.

Learning objective: The global distribution of the mRNA coronavirus disease 2019 vaccine requires consideration of appropriate treatment for postvaccination myocarditis. Eosinophil-mediated immunological injury to cardiomyocytes can be involved in the cause of fulminant inflammation from the pathological findings of postvaccination myocarditis.

Keywords: Autopsy; Coronavirus disease 2019; Eosinophilic myocarditis; Myocarditis; Vaccination; mRNA.

Publication types

Case Reports