Abstract
AMP-activated protein kinase (AMPK) has attracted much attention for its key role in energy homeostasis. Three new papers providing structural information on mammalian and yeast AMPK homologs give insights into the binding of the regulatory nucleotides AMP and ATP and how mutations are associated with cardiac glycogen storage disorders.
MeSH terms
- AMP-Activated Protein Kinases
- Animals
- Humans
- Models, Molecular
- Multienzyme Complexes / chemistry*
- Multienzyme Complexes / metabolism*
- Phosphorylation
- Protein Serine-Threonine Kinases / chemistry*
- Protein Serine-Threonine Kinases / metabolism*
- Protein Structure, Secondary
Substances
- Multienzyme Complexes
- SNF1-related protein kinases
- Protein Serine-Threonine Kinases
- AMP-Activated Protein Kinases