Abstract
In a recent issue of Molecular Cell, Gwinn et al. (2008) suggest a novel mechanism by which AMPK signals to mTOR, and they provide new insight into how information about cellular energy status is fed into decisions about cell growth and proliferation.
MeSH terms
- AMP-Activated Protein Kinases
- Adaptor Proteins, Signal Transducing
- Amino Acid Sequence
- Animals
- Cell Proliferation*
- Humans
- Molecular Sequence Data
- Multienzyme Complexes / genetics
- Multienzyme Complexes / metabolism*
- Protein Kinases / genetics
- Protein Kinases / metabolism
- Protein Serine-Threonine Kinases / genetics
- Protein Serine-Threonine Kinases / metabolism*
- Proteins / genetics
- Proteins / metabolism*
- Proto-Oncogene Proteins c-akt / metabolism
- Regulatory-Associated Protein of mTOR
- Sequence Alignment
- Signal Transduction / physiology
- TOR Serine-Threonine Kinases
- Tuberous Sclerosis Complex 2 Protein
- Tumor Suppressor Proteins / genetics
- Tumor Suppressor Proteins / metabolism
Substances
- Adaptor Proteins, Signal Transducing
- Multienzyme Complexes
- Proteins
- RPTOR protein, human
- Regulatory-Associated Protein of mTOR
- Tuberous Sclerosis Complex 2 Protein
- Tumor Suppressor Proteins
- Protein Kinases
- MTOR protein, human
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins c-akt
- TOR Serine-Threonine Kinases
- AMP-Activated Protein Kinases