Angewandte Chemie International Edition

Volume 54, Issue 37 p. 10833-10837

Communication

Structure Elucidation and Characterization of Different Thyroxine Polymorphs

Santanu Mondal,

Santanu Mondal

Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore-560012 (India)

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Prof. Dr. Govindasamy Mugesh,

Corresponding Author

Prof. Dr. Govindasamy Mugesh

[email protected]

Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore-560012 (India)

Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore-560012 (India)Search for more papers by this author

Santanu Mondal,

Santanu Mondal

Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore-560012 (India)

Search for more papers by this author

Prof. Dr. Govindasamy Mugesh,

Corresponding Author

Prof. Dr. Govindasamy Mugesh

[email protected]

Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore-560012 (India)

Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore-560012 (India)Search for more papers by this author

First published: 24 July 2015

https://doi.org/10.1002/anie.201505281

Citations: 33

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Graphical Abstract

You’d better shape up: Two new polymorphs of the thyroid hormone thyroxine were characterized and it was found that polymorphism has a significant effect on the solubility and stability of this clinically useful compound. The conformational changes alter the electronic properties of the iodine atoms and the reactivity of the CI bonds, which could have a significant effect on the hormone activity.

Abstract

Thyroid hormones regulate almost every process in the body, including body temperature, growth, and heart rate. They influence carbohydrate metabolism, protein synthesis and breakdown, and cardiovascular, renal, and brain function. Two new polymorphs of synthetic L-thyroxine (T4) are reported and the effect of polymorphism on the solubility of this important hormone is shown. Conformational changes were also discovered to have a remarkable effect on the strength of halogen bonding and the reactivity of the CI bonds, which could have a significant effect on the hormone activity.

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Volume54, Issue37

September 7, 2015

Pages 10833-10837

Structure Elucidation and Characterization of Different Thyroxine Polymorphs

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Abstract

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Structure Elucidation and Characterization of Different Thyroxine Polymorphs

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