Thyroid hormones—From Crystal Packing to Activity to Reactivity
Graphical Abstract
Form and substance: Through observation and careful follow-up on polymorphic forms of thyroxine (Forms I und II; black C, gray H, violet I, blue N, red O), Mondal and Mugesh have provided a stunningly simple answer to the apparent non-equivalence of thyroid hormone tablets. Their results further suggest control of deiodinase regioselectivity through the adjustment of torsional angles distant from the reactive bond.