Volume 54, Issue 44 p. 12856-12858
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Thyroid hormones—From Crystal Packing to Activity to Reactivity

Prof. Dr. Ulrich Schweizer

Corresponding Author

Prof. Dr. Ulrich Schweizer

Institut für Biochemie und Molekularbiologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Nussallee 11, 53115 Bonn (Germany)

Institut für Biochemie und Molekularbiologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Nussallee 11, 53115 Bonn (Germany)Search for more papers by this author
Prof. Dr. Clemens Steegborn

Prof. Dr. Clemens Steegborn

Lehrstuhl für Biochemie und Institut für Biomakromoleküle, Universität Bayreuth, Universitätsstr. 30, 95447 Bayreuth (Germany)

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First published: 11 September 2015
Citations: 9

Graphical Abstract

Form and substance: Through observation and careful follow-up on polymorphic forms of thyroxine (Forms I und II; black C, gray H, violet I, blue N, red O), Mondal and Mugesh have provided a stunningly simple answer to the apparent non-equivalence of thyroid hormone tablets. Their results further suggest control of deiodinase regioselectivity through the adjustment of torsional angles distant from the reactive bond.

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